DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pps and Setd1b

DIOPT Version :9

Sequence 1:	NP_001247075.1	Gene:	pps / 41524	FlyBaseID:	FBgn0082831	Length:	2018	Species:	Drosophila melanogaster
Sequence 2:	XP_006530300.1	Gene:	Setd1b / 208043	MGIID:	2652820	Length:	1986	Species:	Mus musculus

Alignment Length:	1944	Identity:	369/1944 - (18%)
Similarity:	563/1944 - (28%)	Gaps:	755/1944 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   405 PLPPPPTTPQHFPELKK--RKEVLEPKAPQIG-----QIIQMPATKS----VPAVFALGRG---- 454
            |:||...|   |.:|..  |:..|.....:.|     :|:..|.||.    ...|||..||
Mouse    98 PVPPKQVT---FAKLNDNVRENFLRDMCKKYGEVEEVEILYNPKTKKHLGIAKVVFATVRGAKEA 159

  Fly   455 ---LPSTSFLKIRPTHQSLPVKRPPLPTTPANSNVRRMPAVQLGRIVNSPQEVKEIIINKNMASP 516
               |.|||.:. ...|..|..|        ..:.:|....:..||.  :||.:           |
Mouse   160 VQHLHSTSVMG-NIIHVELDTK--------GETRMRFYELLVTGRY--TPQTL-----------P 202

  Fly   517 KGVFTNLNTLLGEDNNAATKSSPVPLRHRAVMSPSTPRSSYNQQMSPIVVPVPAQAHTPSKGFMP 581
            .|....::.::.|     |......|:.....|.|....|.:..:            ||:.|..|
Mouse   203 VGELDAISPIVSE-----TLQLSDALKRLKDGSLSAGCGSGSSSV------------TPNSGGTP 250

  Fly   582 IGVDTAQSHKLPAQIVIETHQSSSELAAENDKQLDLINSIVQDELLKSTLVEQPVVNADEDIPKL 646
            ...|||.|                      ..:||..||..|.         .|:.      |:|
Mouse   251 FSQDTAYS----------------------SCRLDTPNSYGQG---------TPIT------PRL 278

  Fly   647 VKML--ESTAADLDPPPVSL----PTNIFPAPEMQGVGNAAAADPNNIMDTANEDEITADFLQHV 705
            ....  :|:.:...|.|..|    ||..|.|                   ..:|.:.|..:
Mouse   279 GTPFSQDSSYSSRQPTPSYLFSQDPTATFKA-------------------RRHESKFTDAY---- 320

  Fly   706 VGLIEEDKQFEAEVV--KQVLASTEP--GTLD-AIVSMPTSIEPVDVPQVQAHTNLLPNASLTEP 765
                  :::.|...|  ..|..:|.|  |:.| :..::.:|..|.......|.|    .|....|
Mouse   321 ------NRRHEHHYVHNSAVAGATAPFRGSSDLSFGTVGSSGTPFKAQSQDATT----FAHTPPP 375

  Fly   766 AQSMTSLPI-ACSTPSRSVAASTPP-------TSAKVVRGYGRVIY------LPPIEAPTTRAKR 816
            ||:.|:... :..:|.::.|...||       |:|...|..|....      |||.|.|   ||.
Mouse   376 AQTATASGFKSAFSPYQTPAPPFPPPPEEPTATAAFGSRDSGEFRRAPAPPPLPPAEPP---AKE 437

  Fly   817 RAQFPSAPGMAATSSSD-AGNLSFGES------------------------SLDASI-------- 848
            :...|..|....::|.: .|..:||.|                        |||:.|
Mouse   438 KPGTPPGPPPPDSNSMELGGRPTFGWSPEPCDSPGTPTLESSPAGPEKPHDSLDSRIEMLLKEQR 502

  Fly   849 ------------------NQPLNTSS--------LSNDSQPG-SGPKRPNPREPSMARRSTAPRR 886
                              ..|:::||        ...:|||| .||..|:.|          |..
Mouse   503 TKLPFLREQDSDTEIQMEGSPISSSSSQLSPLSHFGTNSQPGFRGPSPPSSR----------PSS 557

  Fly   887 SKKLDASQNNDPDASESQEDDD----------------DPNKLWCICRQPHNNRFMICCDLCEDW 935
            :...|.|....||   |.||:|                ||..|
Mouse   558 TGLEDISPTPLPD---SDEDEDLGLGLGPRPPPEPGPPDPMGL---------------------- 597

  Fly   936 FHGTCVGVTKAMGTDMENKGIDWKCPKCVKRQEERSQPRITDMLVTRPTTQPEQRPSE------- 993
                 :|.|..:..|:...    :.|.. :|.:|..|....||.::     .::.||.
Mouse   598 -----LGQTAEVDLDLAGD----RTPTS-ERMDEGQQSSGEDMEIS-----DDEMPSAPITSADC 647

  Fly   994 TKVLTTTAEIVQVAAPS--APRRTLP--------------------------------------V 1018
            .|.:..|.....||||:  ||...||                                      .
Mouse   648 PKPMVVTPGAGAVAAPNVLAPNLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHP 712

  Fly  1019 VLTVASSPMRI-------PMAKPAKKFPTG--------------------AISHQQQQQLNFIRL 1056
            .:||...|:..       |:..|...||.|                    .:|.|.|.|: ..||
Mouse   713 AVTVPPPPLPAPPGVPPPPILPPLPPFPPGLFPVMQVDMSHVLGGQWGGMPMSFQMQTQM-LSRL 776

  Fly  1057 GPSPGKRISETLCVVCKRP----ASTSSVYCGEECIR--KY-AQSAIQAHAATKG----PLPQ-- 1108
            ....|         .|..|    |:.::...|.:.:.  .| :..::......:|    |||:
Mouse   777 MTGQG---------ACPYPPFMAAAAAAASAGLQFVNLPPYRSPFSLSNSGPGRGQHWPPLPKFD 832

  Fly  1109 -NAGAQSLLNNSFDAKKNKKKDLFEDVLRQADTVSKVERINVFERKSGRVITGHMAPSAHQFRKW 1172
             :......:....|..|.....:...||::...:.|.:    ..||...|:      :...|.:|
Mouse   833 PSVPPPGYIPRQEDPHKATVDGVLLVVLKELKAIMKRD----LNRKMVEVV------AFRAFDEW 887

  Fly  1173 LQE-----NPSFEVLPSGTVQSADAEKR-------LLKGAPEAATSTSEPAVLGVA--------- 1216
            ..:     ..|...:.||..:..|..|.       ||:...:......|...||:.
Mouse   888 WDKKERMAKASLTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGAIRLPS 952

  Fly  1217 -----KKPPE----GPAKLSHPQNTTVQASHQLGISSVRPLAKKDKEKTTPTVQAPTPNRIAAGK 1272
                 |:||:    |..|...| :|:|....:          :.::|:......||    ....|
Mouse   953 FKVKRKEPPDTASSGDQKRLRP-STSVDEEDE----------ESERERDRDIADAP----CELTK 1002

  Fly  1273 PEPVRIGIRR--------------SLREQLLARIKEAQAAEENSGQPTTQWPTVLEVDQFVKNVE 1323
            .:|..:|:||              ..:|.|.|  ..:.:|..:||..||. |:....|:
Mouse  1003 RDPKSVGVRRRPGRPLELDSGGEEDEKESLSA--SSSSSASSSSGSSTTS-PSSSASDK------ 1058

  Fly  1324 LEMFNSFGRDVGAKYKAKYRSLMFNIKDRKNRTLFEKICAKQVE------PRQLVRMTPEQLASQ 1382
                                    ..:||::....|:...::.|      ||..: .:|...:|.
Mouse  1059 ------------------------EEEDRESTEEEEEEEEEEAEEEEEEGPRSRI-SSPSSSSSS 1098

  Fly  1383 ELAKWREEENRHQLDMIKKSELDLLACAQNYVVKTHKGEEVIATKVDVTLPEENVSEASSMADTK 1447
            :  |..|::|....|....|::|                       |...|   :||||.    |
Mouse  1099 D--KDDEDDNEADSDGQIDSDID-----------------------DQGAP---LSEASE----K 1131

  Fly  1448 QTSLVSEPSTSTLERSTSREKAGSSKEKRHKSHKHHHRKRSRSRSNSRGRSVDKRHRRQHNEGGE 1512
            ......|..|.::  :||:..|.||......|........|.|.|:|           ..:|..|
Mouse  1132 DNGDSEEEETESI--TTSKAPAESSSSSSESSGSSEFESSSESESSS-----------SSSEDEE 1183

  Fly  1513 Q---PGSGEREHRSREKQSRE----------RDEIVPSPLPKKRDENDQSPVPKKTAEKKTEA-S 1563
            :   ||..|.|....|::...          .:|.:| |...:..|.|::.||........|: .
Mouse  1184 EMTVPGVEEEEEEEEEEEKETAMAAATVVAMAEESMP-PAGGQDFEQDRAEVPLGPRGPMRESLG 1247

  Fly  1564 AYNLVDQILESEKTVEQAANLGKPKPSPKPLPTLPSSLK-APEPMDNYSRYLHGLTTSSLWSGTL 1627
            ....||...|.|....||..|.:|     |||.....|: :|||
Mouse  1248 TEEEVDIEAEDEVPEMQAPELEEP-----PLPMGARKLEGSPEP--------------------- 1286

  Fly  1628 KMIDLADFEIVMYPVQGNCHQLGNLMPSQMDVIGRITRVNVWEYIKKLKKSPTKEVVIVNIFPAS 1692
                         |.:...:..|:::.|                 .:|....|:|..:    |:.
Mouse  1287 -------------PEEPGPNTQGDMLLS-----------------PELPARETEEAQL----PSP 1317

  Fly  1693 PSETYKFDLFFEYLDSRQRLGVLGVDSDQIRDFYIFPLGSGDKLPP--ALQTAEPVPFYEEAQRP 1755
            |..                    |.:||         |....:.||  :|....|:|       |
Mouse  1318 PEH--------------------GPESD---------LDMEPEPPPMLSLPLQPPLP-------P 1346

  Fly  1756 NTLLGIIVRCLSKRPADAVPSTPSVPTPV-----------PALSSKVAKRSRSSISYPAQSSPKR 1809
            ..||    |..|..|....|..|..|.|:           |.|...:|| |:|:.:.||....:.
Mouse  1347 PRLL----RPPSPPPEPETPEPPKPPVPLEPPPEDHPPRTPGLCGSLAK-SQSTETVPATPGGEP 1406

  Fly  1810 KISTHSTSSKDDEFDIDAIIKAPIAKLQKTAPKVVPQPSVPNDADEPYSPG----------GSDD 1864
            .:|..|:.                  |..::|:|   |..|.....| |||          |.|.
Mouse  1407 PLSGSSSG------------------LSLSSPQV---PGSPFSYPSP-SPGLSSGGLPRTPGRDF 1449

  Fly  1865 ELVPSAPQRPNDLERQV--------NEINKQIAAQQMEIAGL------------------LKVEP 1903
            ...|:.|:....|...|        :|....:|:..:...||                  |:.:|
Mouse  1450 SFTPTFPEPSGPLLLPVCPLPTGRRDERTGPLASPVLLETGLPLPLPLPLPLPLALPVPVLRAQP 1514

  Fly  1904 TGSASSSNVLAAISIPANLSKILASIKDKTNLPSSADDGDEEYNPEDDITATSSFASKKP-RSKG 1967
            ........:|     ||.|:.....||.|...|        ..:|...::.........| .:.|
Mouse  1515 RPPPQLPPLL-----PATLAPCPTPIKRKPGRP--------RRSPPSMLSLDGPLVRPPPGPALG 1566

  Fly  1968 RLAHLSEAELLSMVPDNLAGVIPRS----------SRTRHQLAQSPLTPTPLPPPPPPP 2016
            |       :||.:.....|.:.|.:          ..|.......||.|.|.|||||||
Mouse  1567 R-------DLLLLPGQPPAPIFPSAHDPRAVTLDFRNTGIPAPPPPLPPQPPPPPPPPP 1618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pps	NP_001247075.1	TNG2	<827..965	CDD:227367	36/213 (17%)
		PHD_PHF3_like	914..963	CDD:277027	4/48 (8%)
		BRK	1142..1186	CDD:197800	8/48 (17%)
		TFIIS_M	1274..1396	CDD:284835	25/141 (18%)
		SPOC	1623..1729	CDD:285043	11/105 (10%)
Setd1b	XP_006530300.1	RRM_Set1B	100..192	CDD:240993	25/103 (24%)
		N-SET	1698..1841	CDD:371711
		SET_SETD1	1835..1982	CDD:380946
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030