DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pps and Nsd1

DIOPT Version :9

Sequence 1:NP_001247075.1 Gene:pps / 41524 FlyBaseID:FBgn0082831 Length:2018 Species:Drosophila melanogaster
Sequence 2:NP_032765.3 Gene:Nsd1 / 18193 MGIID:1276545 Length:2691 Species:Mus musculus


Alignment Length:2731 Identity:495/2731 - (18%)
Similarity:815/2731 - (29%) Gaps:1094/2731 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 SMVDQE----EDERLEELANFMETATDSELDSDNGSQSGGDNA--SEMDEHDEENHNTGDDNNSD 120
            |.:|.|    |||.:||:  |.||.|::..:.:..|::|.:.|  ||.|...|..|..       
Mouse   167 SEMDPEQPVTEDESIEEI--FEETQTNATCNYEPKSENGVEVAMGSEQDSMPESRHGA------- 222

  Fly   121 STETEAD----APRTRKRVGRKPKAIKKRKRRKPKERPQIVGLRVEQFYADNTADMVVKNALKLA 181
               .|..    ||:|.|              :|.|:|.::.|..             .|.||..|
Mouse   223 ---VERPFLPLAPQTEK--------------QKNKQRSEVDGSN-------------EKTALLPA 257

  Fly   182 GVSVYKRTAETDALMEVIRNDHNYT----PFTSPEQLKNHKRDEKMAMEMQAQSRKIIMQAPG-- 240
            ..|:    .:|:..:|...|..|.:    |.:||..|.|                  :::.||  
Mouse   258 PTSL----GDTNVTVEEQFNSINLSFQDDPDSSPSPLGN------------------MLEIPGTS 300

  Fly   241 ----SVKLINAKKRVQAIPL-----SPVQVKVQRLP-----------VKPHQVQQAAQLQPKVQL 285
                |.:|...:.:.::.||     ..:..|.:|.|           :..|...:.|..:|..:.
Mouse   301 SPSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVANRRPYREY 365

  Fly   286 IRKPIHSPLPRQKPEIIANNSV---NARLRPTRAPV---------KVIAPPVQEYIEDDDDAQSS 338
            ..:....|   .:...:|..::   ..|.:....||         |.....|.:.|....:| |.
Mouse   366 YVEAFGDP---SEKAWVAGKAIVMFEGRHQFEELPVLRKRGKQKEKGYRHKVPQKILSKWEA-SV 426

  Fly   339 DSAEEENADKAYDSEEM--------SEESDEFQESDNDRDSD----------MDFDMRHS--NRR 383
            ..||:.:..|...:::.        |||...|::..||.||:          :.||..||  .:.
Mouse   427 GLAEQYDVPKGSKNQKCVSSSVKLDSEEDMPFEDCTNDPDSEHLLLNGCLKSLAFDSEHSADEKE 491

  Fly   384 NPNKRKRVRKV---VRQTPSKPMKPLPPPPTTPQHFPELKKRKEVLEPKAP-------------- 431
            .|..:.||||.   :::|..|  |.|.|          .:.|||....|.|              
Mouse   492 KPCAKSRVRKSSDNIKRTSVK--KDLVP----------FESRKEERRGKIPDNLGLDFISGGVSD 544

  Fly   432 -----QIGQII-QMPATKSVPAVFALGRGLPSTSFLKIR-PTHQSLP-VKRPPLPTTPANSNVRR 488
                 ::.:|. .:..:.:.|..|.....:.:|:..... |...||. :....|.:..:....:.
Mouse   545 KQASNELSRIANSLTGSSTAPGSFLFSSSVQNTAKTDFETPDCDSLSGLSESALISKHSGEKKKL 609

  Fly   489 MPA------VQLGRIVNSPQEVKEIIINKNMASPKGVFTNL----------NTLLG------EDN 531
            .|.      |||..:....:|.:...::.:..|..|. ::|          |::||      :..
Mouse   610 QPGQVCSSKVQLCYVGAGDEEKRSNSVSVSTTSDDGC-SDLDPTEHNSGFQNSVLGITDAFDKTE 673

  Fly   532 NA------ATKSSPVPLRHR---------------------AVMSPSTPR-SSYNQQMSPIVVPV 568
            ||      .|:.|..|:.:|                     ..|.|.|.. |..|.....|..|:
Mouse   674 NALSVHKNETQYSRYPVTNRIKEKQKSLITNSHADHLMGSTKTMEPETAELSQVNLSDLKISSPI 738

  Fly   569 PAQAHTPSKGFMPIGVDTAQS-------------------------------------HK-LPAQ 595
            |    .|...|...|:.|..|                                     || .|| 
Mouse   739 P----KPQPEFRNDGLTTKFSAPPGIRNENPLTKGGLANQTLLPLKCRQPKFRSIKCKHKESPA- 798

  Fly   596 IVIETHQSSSELAAE------NDKQLDLINSIVQDELLK--STLVEQPVVNADEDIPKLVKMLES 652
             |.||..:|.:|:.:      |...|..|:...:.|.||  :.:.|:...::|.: ..:||.:.|
Mouse   799 -VAETSATSEDLSLKCCSSDTNGSPLANISKSGKGEGLKLLNNMHEKTRDSSDIE-TAVVKHVLS 861

  Fly   653 TAADLDPPPVSLPTNIFPAPEMQGVGNAAAADPNNIMDTANEDEITADFLQHVVGLIEEDKQF-- 715
            ...:|....:|        .::...|.|.|:.|......::::.|.          ||.|.:|  
Mouse   862 ELKELSYRSLS--------EDVSDSGTAKASKPLLFSSASSQNHIP----------IEPDYKFST 908

  Fly   716 ---------------EAEVVKQVLAS------------TEPGTLDAIV---SMPTSIEPVDVPQV 750
                           :..:..|.|||            :..||...:|   |.|.|.:|.|..|.
Mouse   909 LLMMLKDMHDSKTKEQRLMTAQNLASYRTPDRGDCSSGSPVGTSKVLVLGSSTPNSEKPGDSTQD 973

  Fly   751 QAHTNLLP-----------NASLTEPAQSMTSLPIACS------TPSRSVAASTPPT------SA 792
            ..|.:  |           ::||:..|.....|| ||.      .|.|:...:.|.:      ||
Mouse   974 SVHQS--PGGGDSALSGELSSSLSSLASDKRELP-ACGKIRSNCIPRRNCGRAKPSSKLRETISA 1035

  Fly   793 KVVRGYGRVIYLPPIEAPTTRAKRRAQFPSAPGMAATSSSDAGNLSFGESSLDASINQPLNTSSL 857
            ::|:        |.:.....:.:|:.:|...|.: ..:::..||...|      |:|.|..    
Mouse  1036 QMVK--------PSVNPKALKTERKRKFSRLPAV-TLAANRLGNKESG------SVNGPSR---- 1081

  Fly   858 SNDSQPGSGPKRPNPREP--------------------SMARRSTAPRRSKKLDASQN-NDPD-A 900
                   .|.:.|...||                    |.|::|...:..:|..:.:| ..|: .
Mouse  1082 -------GGAEDPGKEEPLQQMDLLRNEDTHFSDVHFDSKAKQSDPDKNLEKEPSFENRKGPELG 1139

  Fly   901 SESQEDDDD--------PNKLWCICRQ------PHNNRF------------MICCDLC----EDW 935
            ||...::|:        |.|.|....|      ...|||            ::..|..    ||:
Mouse  1140 SEMNTENDELHGVNQVVPKKRWQRLNQRRPKPGKRANRFREKENSEGAFGVLLPADAVQKAREDY 1204

  Fly   936 F------------------HGT-----------CVGVTKAMGTDMENKGI--------------- 956
            .                  ||:           |...:..||...:..||               
Mouse  1205 LEQRAPPTSKPEDSAADPNHGSHSESVAPRLNVCEKSSVGMGDVEKETGIPSLMPQTKLPEPAIR 1269

  Fly   957 ----------DW---------------KCPKCVKRQEERSQPRITD-MLVTR--PTTQPEQRPSE 993
                      .|               |..|.|:.|..:...|..| .|:.|  |:.|.:| ..|
Mouse  1270 SEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEDESLLARCQPSAQNKQ-VDE 1333

  Fly   994 TKVLTTTAE--IVQVAAP----------------SAPRRTLPVVLTVASSPMRIPMAKPA----- 1035
            ..:::|..|  :::..||                ..|:.||.|.:...:||      :||     
Mouse  1334 NSLISTKEEPPVLEREAPFLEGPLAQSDLGVTHAELPQLTLSVPVAPEASP------RPALESEE 1392

  Fly  1036 --KKFPTGAISHQQQQQLNFIRLGPSPGKRISET---------------LCVVCKRPASTSSVYC 1083
              .|.|....|.:|::          |.|::.|:               |...|.. ||.|    
Mouse  1393 LLVKTPGNYESKRQRK----------PTKKLLESNDLDPGFMPKKGDLGLSRKCFE-ASRS---- 1442

  Fly  1084 GEECIRKYAQSAIQAHAATKGPL---PQNAGAQSLLNNSFDAKKNKKKDLFED---------VLR 1136
            |...:...|.|.::..:.....:   |:....|.|:......||.||:||.:|         :.|
Mouse  1443 GNGIVESRATSHLKEFSGGTTKIFDKPRKRKRQRLVTARVHYKKVKKEDLTKDTPSSEGELLIHR 1507

  Fly  1137 QADT--------------VSKVERINVFERKSGRVITGHMAPSAHQFRKWL----QENPSFEV-- 1181
            .|.:              :|..:::.| ||..|..:..::..:..:..:.|    |...:|.:  
Mouse  1508 TAASPKEILEEGVEHDPGMSASKKLQV-ERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLEC 1571

  Fly  1182 -----LPSGTV----------------QSADAEKRLLKGAPEAATSTSEPAVLGVAKKPPEGPAK 1225
                 :|.|..                ||.:..||.|  .|.......|..   |.|.||     
Mouse  1572 LGLPEMPRGKFICNECHTGIHTCFVCKQSGEDVKRCL--LPLCGKFYHEEC---VQKYPP----- 1626

  Fly  1226 LSHPQN----------TTVQASHQLGISSVRPLAKKDKEKTTPTVQAPTPNR-----IAAGKPE- 1274
             :..||          .|..|::...:|:       .|.:....|:.|....     :|||... 
Mouse  1627 -TVTQNKGFRCPLHICITCHAANPANVSA-------SKGRLMRCVRCPVAYHANDFCLAAGSKIL 1683

  Fly  1275 -------PVRIGIRRSLREQLLARIKEAQAAEENSGQPTTQWPTVLEVDQ----FVK---NVELE 1325
                   |.....||..|......:.......|..        ::|..|.    |.:   |:::.
Mouse  1684 ASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGG--------SLLCCDSCPAAFHRECLNIDIP 1740

  Fly  1326 MFNSFGRDVGAKYKAKYRSLMFNIKDRKNRTLFEKICAKQVEPRQLVRMTPEQLASQELAKWREE 1390
            ..|.:..|..|..|..||.::: :|..:.|....:||..:..|..:.:|                
Mouse  1741 EGNWYCNDCKAGKKPHYREIVW-VKVGRYRWWPAEICHPRAVPSNIDKM---------------- 1788

  Fly  1391 ENRHQLDMIKKSELDLLACAQNYVVKTHKGEEVIATKVDVTLP--EENVSEASSM---ADTKQTS 1450
              ||.:     .|..:|....|..:.||:..         ..|  |.:||....|   .|.....
Mouse  1789 --RHDV-----GEFPVLFFGSNDYLWTHQAR---------VFPYMEGDVSSKDKMGKGVDGTYKK 1837

  Fly  1451 LVSEPSTSTLERSTSREKAGSSKEKRH--KSHKHHHRKRSR---------------SRSNSRGR- 1497
            .:.|.:....|....:|.....:::::  |...:.|.|.:|               .|.|.:.. 
Mouse  1838 ALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATD 1902

  Fly  1498 ----SVDKR--------------------------HRRQHNE----GGEQPGSG----------- 1517
                .:|..                          .:||:.:    ...|.|.|           
Mouse  1903 ENPCGIDSECINRMLLYECHPTVCPAGVRCQNQCFSKRQYPDVEIFRTLQRGWGLRTKTDIKKGE 1967

  Fly  1518 -----------EREHRSREKQSRE------------RDEIV-----------------PSPLPKK 1542
                       |.|.|:|.:.::|            :|.|:                 |:...:|
Mouse  1968 FVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQK 2032

  Fly  1543 RDENDQSPV---PKKTAEKKTEAS-AYNLVDQILESEKTVEQAANLGKP--------KPSPKPLP 1595
            ...|..:.|   .....:..||.: .|||  :.|.:.|||   ...|.|        :|..:|:.
Mouse  2033 WSVNGDTRVGLFALSDIKAGTELTFNYNL--ECLGNGKTV---CKCGAPNCSGFLGVRPKNQPIV 2092

  Fly  1596 TLPSSLKAPEPMDNYSRYLHGLTTS---------------------------------------- 1620
            |...|.|       :.|..||...|                                        
Mouse  2093 TEEKSRK-------FKRKPHGKRRSQGEVTKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNL 2150

  Fly  1621 -----SLWSGTLKMIDLADFEIVMYPVQGNC----------HQLGNLMPSQMDVIGRITRV---- 1666
                 ..|.......|:...|...:     |          |:.|.|..|::|  ||::..    
Mouse  2151 TKRPAGKWECPWHQCDVCGKEAASF-----CEMCPSSFCKQHREGMLFISKLD--GRLSCTEHDP 2208

  Fly  1667 ---------NVWEYI--------------------------KKLKKSPTKEVVIV---------- 1686
                     .:.||:                          ||..:.||....::          
Mouse  2209 CGPNPLEPGEIREYVPPTATSPPSPGTQPKEQSSEMATQGPKKSDQPPTDATQLLPLSKKALTGS 2273

  Fly  1687 ---NIFPASPSETYKFDLFFEYLDSRQRLGVLGVDSDQIRDFYIFPLGSGDK------------L 1736
               .:.|..|.|.         .||...|      .|:|||.    .|||.|            .
Mouse  2274 CQRPLLPERPPER---------TDSSSHL------LDRIRDL----AGSGTKSQSLVSSQRPQDR 2319

  Fly  1737 PPALQTAEPVPFYEEAQRPNTLLGIIVRCLSKRPADAVPSTPSVP--TPVPALSSKVAK------ 1793
            |||.:...|.|  .:...|.|           ||:.: ||..|:|  .|:....|::.|      
Mouse  2320 PPAKEGPRPQP--PDRASPMT-----------RPSSS-PSVSSLPLERPLRMTDSRLDKSIGAAS 2370

  Fly  1794 -RSRSSISYPAQ-----SSPKRKISTHSTSSKDDEFDIDAIIKAPIAKLQKTAPKVVPQPSVPND 1852
             :|::....||.     |||.|.::|:|                             |:|.:   
Mouse  2371 PKSQAVEKTPASTGLRLSSPDRLLTTNS-----------------------------PKPQI--- 2403

  Fly  1853 ADEPYSPGGSDDELVPSAPQRPNDLERQVNEINKQIAAQQMEIAGLLKVEPTGSASSSNVLAAIS 1917
            :|.|  |..|...|.    ||....|:.::.:.:.:.|::..:      .|....:.|....|:.
Mouse  2404 SDRP--PEKSHASLT----QRLPPPEKVLSAVVQSLVAKEKAL------RPVDQNTQSKHRPAVV 2456

  Fly  1918 IPANLSKILASIKDKTNLPSSADDGDEEYNPEDDITATSSFASKKPRSKGRLAHLSEAELLSMVP 1982
            :  :|..:....|::...|       :|..|:.|.......:|..|.||| |.|:..|.....|.
Mouse  2457 M--DLIDLTPRQKERAASP-------QEVTPQADEKTAMLESSSWPSSKG-LGHIPRATEKISVS 2511

  Fly  1983 DNL--AGVIPRSSRTRHQLAQSP-----LTP-----------------TPL------PPPPPPPG 2017
            ::|  :|.:...|....|..:|.     |:|                 ||:      .||.|.||
Mouse  2512 ESLQPSGKVAAPSEHPWQAVKSLTHARFLSPPSAKAFLYESATQASGRTPVGAEQTPGPPSPAPG 2576

  Fly  2018 V 2018
            :
Mouse  2577 L 2577

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppsNP_001247075.1 TNG2 <827..965 CDD:227367 39/258 (15%)
PHD_PHF3_like 914..963 CDD:277027 17/139 (12%)
BRK 1142..1186 CDD:197800 9/54 (17%)
TFIIS_M 1274..1396 CDD:284835 23/136 (17%)
SPOC 1623..1729 CDD:285043 27/167 (16%)
Nsd1NP_032765.3 MSH6_like 320..430 CDD:99898 17/113 (15%)
TNG2 <1453..1587 CDD:227367 23/134 (17%)
PHD1_NSD1_2 1546..1587 CDD:277118 5/40 (13%)
PHD2_NSD1 1593..1639 CDD:277120 13/56 (23%)
PHD3_NSD1 1640..1693 CDD:277123 10/59 (17%)
PHD4_NSD1 1710..1749 CDD:277126 6/46 (13%)
WHSC1_related 1755..1849 CDD:99899 22/126 (17%)
AWS 1902..1940 CDD:375420 1/37 (3%)
SET_NSD1 1942..2083 CDD:380987 25/145 (17%)
PHD5_NSD1 2121..2163 CDD:277129 1/41 (2%)
C5HCH 2162..2211 CDD:375464 10/55 (18%)
PHA03307 2255..>2576 CDD:223039 82/407 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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