DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pps and C16A11.4

DIOPT Version :9

Sequence 1:	NP_001247075.1	Gene:	pps / 41524	FlyBaseID:	FBgn0082831	Length:	2018	Species:	Drosophila melanogaster
Sequence 2:	NP_494744.2	Gene:	C16A11.4 / 173755	WormBaseID:	WBGene00015817	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	503	Identity:	88/503 - (17%)
Similarity:	157/503 - (31%)	Gaps:	175/503 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   853 NTSSLSNDSQPGSGPKRPNPREPSMARRSTAPRRSKKLDASQNNDPDASESQEDDDDPNKLWCIC 917
            ::|..:|..:|           |...|:||.        |..|..|...|.:          |.|
Worm     3 DSSEEANQFEP-----------PPAIRKSTR--------AVNNLSPHQKEVR----------CQC 38

  Fly   918 RQPHNNRFMICCDLCEDWFHGTCVGVTKAMGTDMENKGIDWKCPKCVKRQEERSQPRITDMLVTR 982
            ...:.:..:|.|..||.|.|..|:.|   |..|:.   :.:||..|        :||:  ::|:|
Worm    39 GTNNTDNRLIKCVECEKWQHAICMSV---MPLDII---MTYKCEMC--------EPRL--LMVSR 87

  Fly   983 PT------TQPEQRPSETKVLTTTA---EIVQVAAPSAPRRTLPVVLTVASSPMRIPMAKPAKKF 1038
            ..      .:||.|....|....:.   |.::..:.::...:.|:.||......     |....:
Worm    88 SQARAYQGVEPEPREVRKKGRNQSVNLEEFLEFLSEASENISRPLALTTLFEDY-----KEHINY 147

  Fly  1039 PTGAISHQQQQQLNFIR-LGPSP--------------GKRISETLCVVCKRPA------------ 1076
            |......::|.:.|.:. :..||              |.|:........:|.|
Worm   148 PQSVRILRKQLESNLLETISMSPNYYADRKAQMLFAMGLRVKGEFLERLERNAVVEVDGYHRITF 212

  Fly  1077 --STSSVYCGEECI--------RKYAQSAIQAHAATKGPLPQNAGAQSLLNNSFDAKKNKKKDLF 1131
              |.:..:.|:..:        ||.|:|..|.|.        |:|.:.            ..|:|
Worm   213 YKSKNLEFRGKHRVGRFPLVNRRKSAESTSQQHG--------NSGEED------------DDDIF 257

  Fly  1132 EDVLRQADTVSKVERINVFERKSGRVITGHMAPSAHQFRKWLQENPSFEVLPSGTVQSADAEKRL 1196
            .|::..                    :||:...:....::.:.:..||.  .:.|:.:|:.|..|
Worm   258 IDLVVP--------------------VTGNSRWNQFPVKQEIPDEQSFG--SASTLPNAEIEPNL 300

  Fly  1197 LKGAPEAATSTSEPAVLGVAKKPP--------------EGPAKLSHP-----------QNTTVQA 1236
            .....:..| |...:...:|..||              ......|:|           |:|.:::
Worm   301 QYSLSDTMT-TGSASTWNMAATPPSEMRGIMMESMNGLHALQSASYPPYQEMQEMLCVQHTMMKS 364

  Fly  1237 SHQLGISSVRPLAKKDKEKTTPTVQAPTPNRIAAGKPEPVRIGIRRSL 1284
            .|:  |...:....::..||         ..||...|.|....:|..|
Worm   365 MHE--IIKTQSDFYREMFKT---------RAIAGAPPAPATTSLRAFL 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pps	NP_001247075.1	TNG2	<827..965	CDD:227367	26/111 (23%)
		PHD_PHF3_like	914..963	CDD:277027	14/48 (29%)
		BRK	1142..1186	CDD:197800	4/43 (9%)
		TFIIS_M	1274..1396	CDD:284835	3/11 (27%)
		SPOC	1623..1729	CDD:285043
C16A11.4	NP_494744.2	PHD_SF	35..78	CDD:389947	14/58 (24%)
C16A11.4	NP_494744.2	SPK	117..221	CDD:367941	14/108 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030