DRSC/TRiP Functional Genomics Resources

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Protein Alignment pps and Nsd2

DIOPT Version :9

Sequence 1:NP_001247075.1 Gene:pps / 41524 FlyBaseID:FBgn0082831 Length:2018 Species:Drosophila melanogaster
Sequence 2:NP_001074571.2 Gene:Nsd2 / 107823 MGIID:1276574 Length:1366 Species:Mus musculus


Alignment Length:1370 Identity:249/1370 - (18%)
Similarity:403/1370 - (29%) Gaps:532/1370 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   585 DTAQSHKLPAQIVIETHQSSSELAAENDKQLDLINSIVQDELLKSTLVEQPVVN-----ADEDIP 644
            |.:||.        |..|.|......|.|:     ||..|.||:..|||..:|:     ||:.||
Mouse   150 DVSQSE--------ENEQKSDNKTRRNRKR-----SIKYDSLLEQGLVEAALVSKISSPADKKIP 201

  Fly   645 KLVKMLESTAADLD---------------------PPPVSLPTNIFPAPEMQGVGNAAAADPNNI 688
            ...:...:|..|.|                     |..||....:....:::|...:|.......
Mouse   202 VKKESCPNTGRDRDLLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHNHTKLKGQKKSARQYHVQF 266

  Fly   689 MDTANEDEITADFLQHVVGLIEEDKQFE-------------AEVVK-------QVLASTEPGTLD 733
            ...|.|   .|...:..:...|.::|||             ||.:|       ::.|..|.|.:.
Mouse   267 FGDAPE---RAWIFEKSLVAFEGEEQFEKLCQESAKQAPTKAEKIKLLKPISGRLRAQWEMGIVQ 328

  Fly   734 AIVSMPTSIEPVDV--------------PQVQAHTNLLPNASLTEPAQSMTSLPIACSTPSRSVA 784
            |..:...|||....              |||.....:     :|||...|.      .:...|..
Mouse   329 AEEAASMSIEERKAKFTFLYVGDQLHLNPQVAKEAGI-----VTEPLGEMV------DSSGASEE 382

  Fly   785 ASTPPTSAKVVRGYGRVIYLPPIEAPTTRAKRRAQFPSAPGMAATSSSDAGNLSFGESSLDASIN 849
            |:..|.|.:            ..:.||.|.:|..:           ||.|.|.. |:...|.|  
Mouse   383 AAVDPGSVR------------EEDIPTKRRRRTKR-----------SSSAENQE-GDPGTDKS-- 421

  Fly   850 QPLNTSSLSNDSQPGSGPKRPNPREPSMARRSTAPRRSKKLDASQ-------NND------PDAS 901
                |.....:::|..|...|..|:.|   ..:|||..|...|:|       :.|      ||||
Mouse   422 ----TPPKMAEAEPKRGVGSPAGRKKS---TGSAPRSRKGDSAAQFLVFCQKHRDEVVAEHPDAS 479

  Fly   902 ESQEDDDDPNKLWCICRQP----HNNRF--MICCDLCEDWFHGTCVGVTKAMGTDMENKGIDWK- 959
             .:|.::.....|.:..:.    :|.:|  ||.....||..:|.....:.....|...:.:|.: 
Mouse   480 -GEEIEELLGSQWSMLNEKQKARYNTKFSLMISAQSEEDSGNGNGKKRSHTKRADDPAEDVDVED 543

  Fly   960 CPKCVKRQEERS----QPRITDMLVTRPTTQPEQRPSETKVLTTTAEIVQVAAP----------- 1009
            .|:...|.::.|    :..|||......:.:..:..|..|....|..:.....|           
Mouse   544 APRKRLRADKHSLRKQRETITDKTARTSSYKAIEAASSLKSQAATKNLSDACKPLKKRNRASATA 608

  Fly  1010 ---------SAPRRTLPVVLTVASSPMRIPMAKP--------------AKKFPTGAISHQQQQ-- 1049
                     |:|..:| ....|:.||...|...|              :||...|..:.::..  
Mouse   609 SSALGFNKSSSPSASL-TEHEVSDSPGDEPSESPYESADETQTEASVSSKKSERGMAAKKEYVCQ 672

  Fly  1050 -------------------QLNFIRLGPSPGKRISET-------LCVVCKRPASTSSV------Y 1082
                               .|..:.|...|..|.:.|       .|.|||.  |...|      .
Mouse   673 LCEKTGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCTECASGIHSCFVCKE--SKMEVKRCVVNQ 735

  Fly  1083 CG----EECIRKY-------------AQSAIQAHAAT-KGPLPQN-------------------- 1109
            ||    |.|::||             ..|.:..||:. ..|.|..                    
Mouse   736 CGKFYHEACVKKYPLTVFESRGFRCPLHSCMSCHASNPSNPRPSKGKMMRCVRCPVAYHGGDACL 800

  Fly  1110 -AGAQSLLNNS------FDAKKNKKKDLFEDVLRQADTVSKVERINVFERKSGRVITGHMAPSAH 1167
             ||...:.:||      |.|:|.|:..               ..:||                  
Mouse   801 AAGCSVIASNSIICTGHFTARKGKRHH---------------THVNV------------------ 832

  Fly  1168 QFRKWLQENPSFEVLPSGTVQSADAEKRLLKGAPEAATSTSEPAVLGVAKKPPEG---------- 1222
               .|     .|.....|::...           ||..:...|..|.:  :.|:|          
Mouse   833 ---SW-----CFVCSKGGSLLCC-----------EACPAAFHPDCLNI--EMPDGSWFCNDCRAG 876

  Fly  1223 -------------------PAKLSHPQNT--TVQ-ASHQLGISSVRPLAKKD-----KEKTTPTV 1260
                               ||::.||:|.  .:| ..|::|...|.....||     :.:..|.:
Mouse   877 KKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYM 941

  Fly  1261 QAPTPNRIAAGKPEPVRIGIRRSLREQLL---ARI------KEAQAAEENSGQPTTQWPTV--LE 1314
            :....:|.     :.|| ||.|..:..|.   ||.      :||:..:|:..:|    |..  ::
Mouse   942 EGDRGSRY-----QGVR-GIGRVFKNALQEAEARFNEVKLQREARETQESERKP----PPYKHIK 996

  Fly  1315 VDQFVKNVELEMFNSFGRDV----------------GAKYKAKYRSLMFNIKDRKNRTLFEKICA 1363
            |::....|::     :..|:                |:..:...|.|||.             |.
Mouse   997 VNKPYGKVQI-----YTADISEIPKCNCKPTDENPCGSDSECLNRMLMFE-------------CH 1043

  Fly  1364 KQVEPR----QLVRMTPEQLASQELAK-----WREEENRHQLDMIKKSELDLLACAQNYVVKTHK 1419
            .||.|.    |....|..|....::.|     |.....|.    |:|.|.     ...||.:...
Mouse  1044 PQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRD----IRKGEF-----VNEYVGELID 1099

  Fly  1420 GEEVIAT-----KVDV------TLPEENVSEASSMAD-TKQTSLVSEPSTSTL------------ 1460
            .||.:|.     :.|:      |:.::.:.:|....: ::..:...:|:..||            
Mouse  1100 EEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGL 1164

  Fly  1461 -----------------------ERSTSREKAG----------------SSKEKRHKSHKHHHRK 1486
                                   |::..|..|.                ||:||..|:.|  ..:
Mouse  1165 FAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSASLSSEEKGKKAKK--KTR 1227

  Fly  1487 RSRSRSNSRGRSVDKRHRRQHNEGGEQP----------------GSGEREHRSRE---------- 1525
            |.|::...:.:|.|:..|  ..:||:..                |.|:|.....|          
Mouse  1228 RRRAKGEGKRQSEDECFR--CGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCG 1290

  Fly  1526 KQSRERDEIVPSPLPKKRDENDQSPVPKKTAEKKT-EASAYNLVDQILESEKTVEQAANLGKPKP 1589
            |.|.....:.|:...|:..:.        ||.:.| :..:|     ..|.:...:.:::....||
Mouse  1291 KPSTSFCHLCPNSFCKEHQDG--------TAFRSTQDGQSY-----CCEHDLRADSSSSTKTEKP 1342

  Fly  1590 SPKPL 1594
            .|:.|
Mouse  1343 FPESL 1347

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
ppsNP_001247075.1 TNG2 <827..965 CDD:227367 36/157 (23%)
PHD_PHF3_like 914..963 CDD:277027 11/55 (20%)
BRK 1142..1186 CDD:197800 4/43 (9%)
TFIIS_M 1274..1396 CDD:284835 31/157 (20%)
SPOC 1623..1729 CDD:285043
Nsd2NP_001074571.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 149..169 6/26 (23%)
MSH6_like 218..337 CDD:99898 19/121 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 373..455 26/120 (22%)
HMG-box 460..>505 CDD:238037 8/45 (18%)
TNG2 <546..711 CDD:227367 25/165 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 595..659 10/64 (16%)
PHD1_NSD1_2 670..712 CDD:277118 5/41 (12%)
PHD2_NSD2 717..763 CDD:277121 12/47 (26%)
PHD3_NSD2 764..817 CDD:277124 9/52 (17%)
PHD_SF 834..874 CDD:389947 9/57 (16%)
WHSC1_related 879..972 CDD:99899 21/98 (21%)
AWS 1013..1063 CDD:197795 11/62 (18%)
SET_NSD2 1063..1204 CDD:380988 20/149 (13%)
S-adenosyl-L-methionine binding. /evidence=ECO:0000250|UniProtKB:O96028 1116..1119 0/2 (0%)