DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pps and kmt2d

DIOPT Version :9

Sequence 1:NP_001247075.1 Gene:pps / 41524 FlyBaseID:FBgn0082831 Length:2018 Species:Drosophila melanogaster
Sequence 2:XP_009295228.1 Gene:kmt2d / 100536523 ZFINID:ZDB-GENE-060223-2 Length:4967 Species:Danio rerio


Alignment Length:2551 Identity:458/2551 - (17%)
Similarity:788/2551 - (30%) Gaps:884/2551 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 VRITSPTPSMVDQEEDERLEELANFMETATDSELDSDNG------------SQSGGDNASEMD-- 104
            :.:.||..|...|:           :.|.:.:.|||.:|            ..:||.:.|...  
Zfish  1755 INVPSPRSSFGRQD-----------LNTGSPASLDSGDGLFKAPMTPRMHQGDAGGLSVSHQSGA 1808

  Fly   105 --EHDEENHNTGDDNNSDSTETEADAPRTRKRVG------RKPKAIKKRKRRKPKERPQIVGLRV 161
              .|..|::.......||........||.:...|      |.|.|.::...|.|.. ||..|   
Zfish  1809 SPNHPLESYRQSPSTFSDPYAQPPLTPRPQSGDGSSPLPQRLPAAQQEAYSRLPSS-PQSQG--- 1869

  Fly   162 EQFYADNTADMVVKNALKLAGVSVYK----RTAETDALMEVIRNDHNYTPFTSPEQLKNHKRDEK 222
                  ::...:...|:....:||..    |....|..........:..||.|   |....|...
Zfish  1870 ------SSQSPLTPGAISNDVLSVQSPATPRFQSPDPYSRPPSRPQSRDPFAS---LHKPPRPSS 1925

  Fly   223 MAMEMQAQSRKII---MQAPGSVKLIN-AKKRVQAIPLSP---VQVKVQRLPVKPHQVQQAAQLQ 280
            :|.|..:..|...   .|.|.|..:.: ...:..|...||   :|:..|::..:.|...|.||  
Zfish  1926 VAPEGNSPFRGSPHPGQQPPCSPSVADPLSGKPPAFSCSPGVGIQMGPQQIVGQQHMTPQQAQ-- 1988

  Fly   281 PKVQLIRKPIHSPLPRQKPEIIANNSVNARL-----------RPTRAPVKVIAPPVQEYIEDDDD 334
                     :|...|:.:.:.:..: .|:|:           ||:..|.....|.:|: |.|...
Zfish  1989 ---------VHLQQPQSQTQQVGAD-FNSRIALPPGNQDTAVRPSDGPHLPNIPGMQD-ISDMSA 2042

  Fly   335 AQSSDSAEEENADKAYDSEEMSEESDEF------------QESD---------NDRDSDMDFDMR 378
            ||  |.|....:....:.....:...||            ||.:         :.:|.:|....:
Zfish  2043 AQ--DPALMSLSPSELEKHRQRQRLREFLIRQKMQRNSLRQEKEAPVVSNPAQSWQDGEMPAFQQ 2105

  Fly   379 HSNRRNPNKRKRVRKVVRQTPSKPMKPL-----------PPPPTTPQHFPELKKRKEVLEPKA-P 431
            ..::|.|....:.|..|.|.......||           ||||.||.:          ::|.| .
Zfish  2106 DKSQRAPPPYPQDRAAVTQAALASRMPLPMGVMDEKLCRPPPPGTPAN----------MDPSALR 2160

  Fly   432 QIGQIIQ-MPATKSVPAVF---ALGRGLPSTSFLKIRP-THQSLPVKRP-----------PLPTT 480
            |.|.:.| |......||.:   ...|..|..|.::..| .|.:.|:..|           ||.|.
Zfish  2161 QAGPVSQGMYPRPQFPAQWQNQGAPRRFPQPSMIEAVPRQHLTTPINNPLNMQSMQNMPNPLTTV 2225

  Fly   481 PANSNVRRMPAVQLGRIVNSPQEVKEIIINKNMASPKGVF---------------TNLNTLLGED 530
            |....    .||| ..:..:|.:..|:..|.....|...|               ..:|....:.
Zfish  2226 PGTGT----EAVQ-SHVSGAPPQFIELRHNSQRMPPGPQFMQRAPIPRARMFLPQQEMNAAFAQQ 2285

  Fly   531 N-NAATKSSPVPLRHRAVMSPSTPRSSYNQQMSPIVVPVPAQAHTPSKGFMPIGVDTAQSHKLPA 594
            | .::..:|.|.:|        .||....|....:::...:.|..|.....|..|.|.    .|.
Zfish  2286 NLTSSLDASAVGMR--------DPRLGLQQGGMDLLMQQQSNAPPPQSQLQPQQVPTT----TPK 2338

  Fly   595 QIVIETHQSSSELAAENDKQLDLINSIVQDELLKSTLVE--------QPVVNA---DEDIPKLVK 648
            ..:..|.|...:..:...:|.. :|.:   :|.:|.||:        .||...   |:|:     
Zfish  2339 TQISHTTQQLPQTTSIGSQQTG-VNPV---DLPESDLVDAFAPKGLSDPVAETGVEDDDL----- 2394

  Fly   649 MLESTAADLDPPPVSLPTNIFPAPEMQGVGNAAAADPNNIMDTANEDEITADFLQHVVGLIE--E 711
                 ..||||....        .::..:.|..|.|| ::.|..|.||.  |.|.:....::  :
Zfish  2395 -----GLDLDPDKGD--------DDLGNLDNLEANDP-HLDDLLNSDEF--DLLAYTDPELDQGD 2443

  Fly   712 DKQFEAEVVKQVLASTEPGTLDAIVSMPTSIEP-------------------------VDVPQVQ 751
            .|...::.::.|.|..|.....|.|.:...::|                         |:.|:|:
Zfish  2444 PKDVFSDQLRLVEAEVEGPVSSANVEVKVEVKPKVEMASQDTRTTATQPPLKTENSSAVNTPKVE 2508

  Fly   752 AHTNL------LPNASLTEPAQS---------MTSLPIACSTPSRSVAASTPPTSAKVVRGYGRV 801
            :...:      |.:..|.|..||         ..::.:..|....|....||..:...|| .|.:
Zfish  2509 SSDVISLSSVKLEDKGLVEQPQSGQASVKDDISETVSVLLSGTKASNQPDTPTANLNTVR-LGGI 2572

  Fly   802 IYLPPIEAPTTRAKRRAQFP---SAP-GMAATS-SSDAGNLSFGESSLDASINQPL--------- 852
            .:..|.:|.|......|..|   |.| |:..:. .|.|.:|...||||:|| ..||         
Zfish  2573 PFPLPSQADTLSFPATAPHPDLGSDPLGLPDSGHHSTADDLDKVESSLEAS-ELPLLIQDLLEHE 2636

  Fly   853 -------------------NTSSLSNDSQPGSG------PKRPNPREPSMARRSTAPR------- 885
                               ...|:.|..||...      |:..:|.:..:.:....||       
Zfish  2637 KKELQKQQQLSALQGGIGSQIHSIQNQQQPPQTTNQIMMPQHHHPSQGIVPQAGMVPRPPHMFPQ 2701

  Fly   886 -RSKKLDASQNNDPDASESQEDDDDPNKLWCICRQPHNNRFMICCDLCEDWFHGTCVGVTKAMGT 949
             :.:.:.|:..:.|.|:..|              ||                     |:.:....
Zfish  2702 QQQRLISAAMPSPPHAAMGQ--------------QP---------------------GILRGGQP 2731

  Fly   950 DMENKGIDWKCPKCVKRQEERSQPRITDMLVTRPTTQPEQR--PSETKVLTTTAEIVQVAAPSAP 1012
            ...:.|:   .|     |::.:||         |....:|.  |.:......|.:|:...|.:..
Zfish  2732 GRLHPGL---AP-----QQQTTQP---------PHIGKQQNFFPDKDLDKFMTDDIIDPIAKAKM 2779

  Fly  1013 RRTLPVVLTVASSPMRIPMAKPAKKFPTGAISHQQQQQLNFIRLGPSPGKRISETLCVVCKRPAS 1077
            .....:...:|..||.:|..           .::||..|...||..:||...|:.       |.:
Zfish  2780 IALKGINRVLAQDPMGVPPG-----------MNRQQVSLLAQRLTSAPGNEDSQP-------PPA 2826

  Fly  1078 TSSVYCGE------------------------------------ECIRKYAQSAIQAHAATKGPL 1106
            ..|...||                                    :...|:.:..|.||..::..|
Zfish  2827 PGSSKEGEGSNQVQTRPNPPQFGIINDAEQHQYEEWLVHTQQLLQMQLKFLEEQIGAHRKSRKAL 2891

  Fly  1107 PQNAGAQSLLNNSF-DAKKNKKKDLFED---VLRQADTVSK--VERINVF----------ERKSG 1155
            .............| :|...|.|.:.|:   :.:|.|.|.|  .|..|:.          ::.|.
Zfish  2892 CAKQRTAKKAGREFAEADAEKLKLVTEEQSKIQKQLDQVRKQQKEHTNLIAEYRSKQQQHQQGSS 2956

  Fly  1156 RVITGHMAPSAHQFRKWLQENPSFEVLPSGTVQSADAEKRLLKGAPEAATSTSEPAVLGVAKKPP 1220
            .:..|...|:.|...|          :|...:.....      |.|:||             .||
Zfish  2957 MLAPGPSTPAPHMLSK----------MPGQMIGQPPG------GMPQAA-------------MPP 2992

  Fly  1221 EG-PAKLSHPQN-TTVQASHQLGISSVRPLAKKDKEKTTPT---VQAPTPNRIAAGKPEPVRIGI 1280
            .| |.::...|. ...|.|..||...|:|          |.   .|.|.|.     .|:| |:..
Zfish  2993 GGMPIRMPQMQPFGAAQPSLPLGAGPVQP----------PPGFFPQGPGPQ-----APDP-RVLQ 3041

  Fly  1281 RRSLREQLLARIKEAQ-----AAEENSGQPTTQWPTVLEVDQFVKNVELEMFNSFGRDVGAKYKA 1340
            .|..:.|::.::::.|     |.:..|.||  |.|.::                 .:..||....
Zfish  3042 ERQYKMQMVQKMQQQQQQLMMAQQPMSHQP--QQPGIM-----------------NQQPGAMGSQ 3087

  Fly  1341 KYRSLMFNIKDRKNRTLFEKICAKQVEPRQLVRMTPEQLASQELAKWREE--------------- 1390
            ..:.||.::   ....|.:.:...|...:.||:..|..:.:|.|.:.:..               
Zfish  3088 PAQVLMGSL---GQPNLQQGLINSQQNQQGLVQTPPGMMGNQALGQTQHNVMGQQMTQTANLMAG 3149

  Fly  1391 ------ENRHQLDMIKKSE--LDLLACAQNYVVK------THKGEEVIATKVDVTLPEENVSEAS 1441
                  .|:..:..:::.:  :|.......:||:      |.:.:.|:|.::.::..::|.  |.
Zfish  3150 QPQGMVGNQQIVQQLQRPQVLMDQHGPVGQHVVRGPPTQLTPQQQSVMAQRMLMSQQQQNA--AK 3212

  Fly  1442 SMADTKQTSLVSEPSTSTLERSTSREKAGSSKEKRHKSHKHHHRKRSRSRSNSRGRSVD-----K 1501
            |:|..:|..::.           .:::||.|:.:|        ...:.|...::|.:.:     :
Zfish  3213 SLAQLQQQQILQ-----------LKQQAGPSEPQR--------ALEAPSSGGNQGVAENLQQGVQ 3258

  Fly  1502 RHRRQHNEGG-------EQPGSGEREHRSREKQSRERDEIVPSPLPKKRDENDQSPVPKKTAEKK 1559
            .|:..:.:||       .|.|......:.::..|.|:..:|..|..:......|.....:|.:..
Zfish  3259 DHQNPNKDGGLLSPKTPPQQGGPPTPLQMQQGSSGEQQCVVGQPQQQHAFLGQQQTAQPQTNQNI 3323

  Fly  1560 TEASAYNLVDQILESEKTVEQAANLGKPKPSPKPLPTLPSSLKAPEPMDNYSRYLHGLTTSSLWS 1624
            ..|..:..||.        :||....|.:|   |.|.:...|:..             |...:..
Zfish  3324 GVAEQHGFVDN--------QQAGPHLKVQP---PQPQMQIGLQTQ-------------TKIQIKQ 3364

  Fly  1625 GTLKMIDLADFE----IVMYP----VQGNCHQLGN--------LMPSQMDV-------------- 1659
            ...:|..:|..:    ....|    ||.:...:||        |:..||.:              
Zfish  3365 EDQQMCFMAQQQAGQIAAQQPQGVAVQNSGQTMGNITNQQQQALLTQQMGIPRAQQMMMTQRPGA 3429

  Fly  1660 -IGRI-TRVNVWEYIKKLKK----SPTKEVVIV-------------------------------- 1686
             .|:| |.:|:..:|.:..:    :|::::..:                                
Zfish  3430 PAGQIRTSINIQAFIAQNPQLRHLTPSQQLQQIQAMLAQRQLQQGQMLRLQGQAQGQMRPQVLQG 3494

  Fly  1687 -NIFPASP-----SETYKFDLFFEYLDS-RQRLGVLGVDSDQIRDFYIFPLG-----SGDKLPPA 1739
             ::.|..|     .:.::|.|..::..| :|:.||:...|.....|:...:|     |...||..
Zfish  3495 PSVGPRIPVIETQQQQHRFGLAGKHGSSTQQQPGVIRQQSGMAPQFHQGVIGAMQQPSQGPLPQY 3559

  Fly  1740 LQTAEPVPFYEEAQ------------RP------NTLLGIIVRCLSKR----------------- 1769
            :.:|:.....::.|            ||      ||..|.:.|.:|.|                 
Zfish  3560 INSAQQQQMIQQQQVHQHQMMRGQVPRPIMGQVRNTAPGHLARPMSPRQLLGQGSPGSPLSNQQR 3624

  Fly  1770 -------------------------PADAVPS--------------TPSVPTPVP---ALSSKVA 1792
                                     |..|.||              :||:..|.|   ||||.::
Zfish  3625 LVRMSQTPPGTQHLQQQTHGTTALSPFQASPSHAGSPAGSSVPEAGSPSLNKPEPGNMALSSNLS 3689

  Fly  1793 KRSRSSISYPAQSSPKRKISTHSTSSKDDEFDIDAIIKAPIAKLQK------TAP-------KVV 1844
            ..||          |:..:...|..|:.... |.:.:::|.||.|.      :||       ..|
Zfish  3690 SPSR----------PEGIVGKSSPFSQTGGL-IPSPLRSPTAKTQSPNTEALSAPFPLNGPSSQV 3743

  Fly  1845 PQPSVPNDAD---------------------------------------EPYSPG---------- 1860
            .|...||...                                       |.:|.|          
Zfish  3744 AQNQAPNSGQISGGHTSQPTQMPSEMCKMTLQNIKQEPREVQCDTGNIVETHSDGIKREISGESV 3808

  Fly  1861 ----------GSDDEL--VPSAPQRPND----LERQVNEINKQIAAQQ------MEIAG------ 1897
                      ||.::.  :.|..||...    |::.:...|.|:|||:      .||.|      
Zfish  3809 SGSGIVNSAVGSRNQAGDIGSQIQRTETGQQLLQKLLRTKNLQVAAQRPSDGIHNEINGHINNKL 3873

  Fly  1898 -LLKVEPTGSASSSNVLAAISIPANLSKILASIKDKTNLPSSADDGDEE---------------- 1945
             :|:.:..|:..:...|.:::..|.:.|...:.|.....|:|.....:|                
Zfish  3874 AMLEQKLQGTPRNMEDLQSLTKRAPIVKAKRTAKAGERGPNSRKKTKKEEVGKTEAIMKQLKQGL 3938

  Fly  1946 -YNP--EDDITAT--------SSFASKKPRSKGRLAHLSEAELLSMVPDNLAGVIPRSSRTRHQL 1999
             ..|  |..|||:        ||.|:.|.:.||...:    .:|..:||..:.::     |::.|
Zfish  3939 SLLPLMEPSITASLDLFAPFGSSPANAKTQLKGSFGN----AILDNIPDYYSQLL-----TKNNL 3994

  Fly  2000 AQSPLTPTPLPPPPPP 2015
            :..|..|:.|||.|||
Zfish  3995 SNPPTPPSSLPPTPPP 4010

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppsNP_001247075.1 TNG2 <827..965 CDD:227367 28/180 (16%)
PHD_PHF3_like 914..963 CDD:277027 5/48 (10%)
BRK 1142..1186 CDD:197800 9/55 (16%)
TFIIS_M 1274..1396 CDD:284835 23/147 (16%)
SPOC 1623..1729 CDD:285043 26/180 (14%)
kmt2dXP_009295228.1 PHD_SF 122..205 CDD:304600
PHD1_KMT2C_like 218..263 CDD:276984
PHD_SF 265..310 CDD:304600
PHD 346..391 CDD:214584
PHD_SF 821..871 CDD:304600
PHD5_KMT2C_like 872..918 CDD:276988
PHD5_KMT2D 949..999 CDD:277074
HMG 1473..1528 CDD:197700
Med15 3305..>3717 CDD:255446 71/446 (16%)
PHD_SF 4462..4568 CDD:304600
FYRN 4612..4662 CDD:283589
FYRC 4668..4749 CDD:283590
SET 4828..4949 CDD:214614
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.030

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