DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pps and dido1

DIOPT Version :9

Sequence 1:	NP_001247075.1	Gene:	pps / 41524	FlyBaseID:	FBgn0082831	Length:	2018	Species:	Drosophila melanogaster
Sequence 2:	XP_002943242.2	Gene:	dido1 / 100135007	XenbaseID:	XB-GENE-959739	Length:	2280	Species:	Xenopus tropicalis

Alignment Length:	1606	Identity:	349/1606 - (21%)
Similarity:	571/1606 - (35%)	Gaps:	543/1606 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   822 SAPGMA-ATSSSDAGNLSFGESSLDASINQPLNTSSLSNDSQPGSGPKRPNPREP------SMAR 879
            |.|..| .|..|:.|  |.||.::.   .:..|.::|.....|...|.:..|..|      ....
Frog   197 SVPTQALGTPKSEPG--STGECTVR---TRSANRAALLQQQTPIKSPIKQEPESPPPSEEQKQEE 256

  Fly   880 RSTAPRRSKKLDASQNNDPDASESQEDDDDPNKLWCICRQPHNNRFMICCDLCEDWFHGTCVGVT 944
            .|.:|:|               .|:.:..|||.|:|||||.||||||||||.||:||||.|||:.
Frog   257 TSISPKR---------------RSETEIYDPNALYCICRQRHNNRFMICCDRCEEWFHGDCVGIP 306

  Fly   945 KAMGTDMENKGIDWKCPKCVKRQEERSQPRITDMLVTRPTTQPEQRPSETKVLTTTA-------- 1001
            :|.|..:|..|.|:.||.|..:|.:......:|.      .:..|..||.::.|..:
Frog   307 EARGRLLERNGEDYICPNCTIQQSQAESATDSDQ------KEDPQYNSEMRIETAESSDDQGIKG 365

  Fly  1002 EIVQVAAPSAPRRTLPVV-----LTVASSPMRIPMAKPAKKFPTGAISHQQQQQLNFIRLGPSPG 1061
            .|.:.||.|:.::.|.:.     .||.|.|.  |::.|::...:..::.         .:||.
Frog   366 RIEKKAAHSSGKKKLKIFHPVPQSTVVSEPP--PLSGPSEASDSSEVAR---------CIGPG-- 417

  Fly  1062 KRISETLCVVCKRPASTSSVYCGEECIRKYAQSAIQAHAATKGPLPQ---NAGAQSLLNNSFDAK 1123
                      |...|...||||..:||.|:|.:|:::....|...|:   ....:..:.....|.
Frog   418 ----------CSNLALPDSVYCSHDCILKHAAAAMKSLNVAKDVKPKEKIKVKTEKRIQPKPQAS 472

  Fly  1124 KNKKKDLFEDVLRQADTVSK-VERINV-FERKSGRVITGHMAPSAHQFRKWLQENPSFEVLPSGT 1186
            ........|.|..:.::|:| |..:|| .|..:.....|...||......::...|......|.|
Frog   473 AKPPTSPMEPVSERKESVAKRVPDMNVKVEAANEPRAEGSSTPSWESDHNYIAVKPEKTAAISST 537

  Fly  1187 V-----QSADAEKR-LLKGAPEAATSTSEPAVLGVAKKP----PEGPAKLSHPQNTTVQASHQLG 1241
            :     :..:.||: .:..:|.|..|...| ...:..||    |..|.|.|| ..|.::...:..
Frog   538 LFYKSEKVEEVEKKPEVPASPPAKASVPCP-YTSMVMKPISSLPRIPKKDSH-STTPIKPLPKPA 600

  Fly  1242 ISSVRPLAKKD-KEKTTPTVQAPTP-------------------------------------NRI 1268
            :||..|:..|. ::.|.|....|:|                                     .::
Frog   601 VSSKSPIQNKGVRQPTKPADSKPSPVPKKPPAPSLPSAPSQKKAIPSKLPLGQKKSAAPSPSTKV 665

  Fly  1269 AAGKPEP----------------------------VRIGIRRSLREQLLARIKEAQ--AAEENSG 1303
            |.|.|.|                            :|..|||||::.|..|:.::.  ...||
Frog   666 AMGNPPPRPTANTSQPTSSTPQSAQSSSHPVPNMQIRQNIRRSLKQILWKRVIDSDDLVMVEN-- 728

  Fly  1304 QPTTQWPTVLEVDQFVKNVELEMFNSFGRDVGAKYKAKYRSLMFNIKDRKNRTLFEKICAKQVEP 1368
                      ||.:...|:|.||||.: ||..::||||||::|||:||.||:.|:.::..:::..
Frog   729 ----------EVARIATNIEREMFNLY-RDTDSRYKAKYRNIMFNLKDPKNQGLYHRVLKEEIPL 782

  Fly  1369 RQLVRMTPEQLASQELAKWREEENRHQLDMIKKSELDLLACAQNYVVKTHKGEEVIATKVDVTLP 1433
            .:|||:.||:|||::|:.|:|..:|..|.:..|:.::....:.|..|...:...:..|..:...|
Frog   783 AKLVRLKPEELASRKLSSWKETGSRSGLVLKSKARMENKIPSMNQAVDMEESPPMSDTDTEQQEP 847

  Fly  1434 EENVSEASSMADTKQTSLVSEPSTSTLERSTSREKAGSSKEKRHKSHKHHHRKRSRSRSNSRGRS 1498
            .:...|.:       ||::.:..:|.|..:||          :|::|....:.:..:
Frog   848 AQAPPETN-------TSVLPDIFSSMLSDTTS----------QHRAHLFDLKCKICT-------- 887

  Fly  1499 VDKRHRRQHNEGGEQPGSGEREHRSREK---QSRERDEIVPSPLPKKRDENDQSPVPKKTAEKKT 1560
                        |:.|...|..:: |.|   .:.::.::...|.||  :|:...|.|.:.|| .|
Frog   888 ------------GQIPADDEPPYK-RPKTTTAAAKKPDLNSKPEPK--EESSVIPPPPEPAE-NT 936

  Fly  1561 EASAYNLVDQILESEKTVEQAANLGKPKPSPKPLPTLP--------------------------- 1598
            |:   |...:|.::.:.:.:||.|  |.|.|...||||
Frog   937 ES---NPPMEICDNAENIPEAAPL--PVPLPSESPTLPDPIYSSHAPVYPSPAPVTTVTVSGRDP 996

  Fly  1599 -SSLKAP-----------------------------------------EPMDNYSRYL------- 1614
             :::|.|                                         :|:.:.||||
Frog   997 RTAIKRPLTVSSNPDIGARSSRENEEAPTEPPKPLLPQVFSMPKSILSKPLPSESRYLASASPNI 1061

  Fly  1615 ---------HGLTT------SSLWSGTLKMIDLADFEIVMYPVQGNCHQLGNLMPSQMDVIGRIT 1664
                     .|.|:      :.:|.|.:.|..:|.|....|||.|:...|...:|..:.:.|||:
Frog  1062 NLTEMRPPKEGDTSLFLSRLNPIWKGFINMQSVAKFVTKAYPVSGSVEYLNEDLPDTIHIGGRIS 1126

  Fly  1665 RVNVWEYIKKLKKSPTKEVVIVNIFPASPSETYKFDLFFEYLDSRQRLGVLGVDSDQIRDFYIFP 1729
            ...||:|:.|||.|.:||:.::...||:..|...:...:.|..||.|.||:..::..::|.|:.|
Frog  1127 PKTVWDYVGKLKSSQSKELSLIRFHPATEEEEVAYISLYSYFSSRCRFGVVANNNRHVKDLYLIP 1191

  Fly  1730 LGSGDKLPPALQTAEPVPFYE---EAQRPNTLLGIIVRCLSKRP--------------------- 1770
            |.:.|.:|..|     :||..   ||.|||.:||:::...:|||
Frog  1192 LSAKDPIPSKL-----LPFDGPGLEATRPNLILGLVICQRNKRPVTSETEKLEDKRTKSGGQEDT 1251

  Fly  1771 -------------------------ADAVPST--PSVPTPVPALSSKVA----KRSRSSISYPAQ 1804
                                     .::|.||  |..|.|:|...:||.    ...::....|..
Frog  1252 EVGNVTKGALSSQAEKMPHKYQPYAGESVKSTAPPGSPPPLPEALAKVVAPVIALGKAEGVLPVH 1316

  Fly  1805 SS-PKRKISTHSTSSKDDEFDIDAIIKAPIAKLQK-----TAPKVVP------------QPSV-- 1849
            |: |....:..::|:......::.|:|....|...     :||||.|            .|.|
Frog  1317 SAVPHSPTAESASSASKGATPLEHILKTLFGKSDNKNDNPSAPKVDPPKDKGLVGLPLIDPIVQQ 1381

  Fly  1850 ----------------PNDADEPYSPGGS-----------------------DDEL--------- 1866
                            |.|.:|.|.|..:                       |||.
Frog  1382 FGLLSKDKAIEEEDDRPYDPEEEYDPEKAFGTTMVTNNDKPYEPEQPCESLEDDEAYDPEDETIL 1446

  Fly  1867 ------VPSAPQRPNDL------------------------ERQVNEINKQIAAQQMEIA----- 1896
                  |...|.|.:.|                        ::.:.|:||||..|:.::.
Frog  1447 EEAKVSVEDLPNRMSALNKLKPEMTAEYLQGISDSSSLVEQKKMLEELNKQIEEQKRQLEEQEEA 1511

  Fly  1897 -------------------GLLKVEPTGSASSSNV---------LAAISIPANLSKILASIKD-- 1931
                               .|:...|..|...|.:         :.:.|:|   .|::.|.:|
Frog  1512 LRLQRAAVGVSMAHFSVSDALMSPPPKSSLLKSELFPQEPGPIKILSPSVP---EKVIHSSRDPR 1573

  Fly  1932 --------------KTNLPSSADDGDEEYNPEDDITATSSFASKK---PRSKGRLAHLSEAELLS 1979
                          ..|.|.:....||::....::..|...:|.|   ..|....|||:.||..
Frog  1574 QSRDPRQASSKMAHPENEPLNQTPHDEKHVQTPEVHTTDQDSSVKLASEESASSAAHLNPAETY- 1637

  Fly  1980 MVPDNLAGVIPRSS--RTRHQLAQSP---------------LTPTP 2008
                 |.|..|..:  ..:|:.:||.               |.|||
Frog  1638 -----LKGNKPEMAAWHVQHENSQSESPQETLETTRPSRKVLLPTP 1678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pps	NP_001247075.1	TNG2	<827..965	CDD:227367	53/144 (37%)
		PHD_PHF3_like	914..963	CDD:277027	31/48 (65%)
		BRK	1142..1186	CDD:197800	10/45 (22%)
		TFIIS_M	1274..1396	CDD:284835	47/151 (31%)
		SPOC	1623..1729	CDD:285043	34/105 (32%)
dido1	XP_002943242.2	TNG2	<177..328	CDD:227367	55/150 (37%)
		PHD_DIDO1_like	272..325	CDD:277109	34/52 (65%)
		TFS2M	703..804	CDD:128786	43/113 (38%)
		Herpes_BLLF1	<862..>1106	CDD:282904	50/282 (18%)
		SPOC	1077..1225	CDD:400205	48/152 (32%)
		PHA03247	<1531..2085	CDD:223021	32/157 (20%)
		SF-CC1	2127..>2177	CDD:273721
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7210
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007937
OrthoInspector	1	1.000	-	-		otm49033
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030