DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pps and nsd3

DIOPT Version :9

Sequence 1:	NP_001247075.1	Gene:	pps / 41524	FlyBaseID:	FBgn0082831	Length:	2018	Species:	Drosophila melanogaster
Sequence 2:	XP_005155379.1	Gene:	nsd3 / 100006350	ZFINID:	ZDB-GENE-050324-2	Length:	1563	Species:	Danio rerio

Alignment Length:	1023	Identity:	194/1023 - (18%)
Similarity:	315/1023 - (30%)	Gaps:	378/1023 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   674 MQGVGNAAAADPNNIMDTANEDEITADFLQHVVGLIEEDKQFEAEVVKQVLASTEPG------TL 732
            |||:.......|..::|:||               |.::..:|        |.::||      ..
Zfish     8 MQGIMGNTIQQPPQLIDSAN---------------IRQEDVYE--------AISDPGDDGGQQNF 49

  Fly   733 DAIVSMPTSIEPVDVPQVQAHTNLLPNASLTEPAQSMTSLPIACSTPSRSVAASTPPTSAK---V 794
            |:.:....|....|||.:   ||..|....|...|:..:|           .:..|..||.   .
Zfish    50 DSPLESGFSYPAEDVPVI---TNGYPTGVGTYEQQAKFAL-----------YSQFPNGSANGYGA 100

  Fly   795 VRGYG--------RVIYLPPI--EAPTTRA--------------------KRRAQ---------- 819
            :|.||        ..:..||:  |.|.|..                    :::.|
Zfish   101 IRNYGDHSLLLGEGTVLRPPVVQEKPQTHISPPSHSHHHQQPHHPHHHHHQQQQQHHPHNPPLLP 165

  Fly   820 -----------------FPSAPGMAATSSSDAGNLSFGESSLDASINQPLNTSSLSNDSQPGSGP 867
                             .|..|.:...||...  ||..||::...|.||:||...:.       |
Zfish   166 HHHHHHPPPASHLMPQVLPPPPPLLLPSSPPL--LSPQESTISNPIGQPVNTIITTT-------P 221

  Fly   868 KRPNPREPSMARRSTAPRRSKKLDASQNNDPDASESQEDDDDPNKLWCICRQPHNNRFMICCDLC 932
            |           ::::|....|:..:..|..:..||.                      :|.||.
Zfish   222 K-----------KTSSPEIKLKIIKTYQNGRELFESS----------------------LCGDLL 253

  Fly   933 EDWFHGTCVGVTKAMGTDMENKGIDWKCPKCVKR-------QEERSQPRITD----MLVTRP--T 984
            :::          ..|.|...:. :.|..|..||       .||..||...:    ::|..|  |
Zfish   254 QEF----------QAGEDSRRQH-EQKKEKRKKRGSRHGAGHEESQQPSKVEEERSVVVHNPVQT 307

  Fly   985 TQ------PEQRPSETKVLTTTAEIVQVAAPSAPRRTLPVVLTVASSPMRIPMAKPAKKFPTGAI 1043
            |:      .||:| ::.:.:..||:.:    ....:..|.|:|                 .||..
Zfish   308 TESQVAFREEQQP-QSSLKSPKAELKE----QKVEKHCPSVIT-----------------STGTS 350

  Fly  1044 SHQQQQQLNFIRLGPSPGKRISETLCVVCKRPASTSSVYCGEECIRKYAQSAIQAHAATKGPLPQ 1108
            ...:...|.:.::|..|.     ..|:|...|.|...........::|       |....|.:|:
Zfish   351 QEYEIGDLVWAKVGTYPW-----WPCMVSSDPQSNVHTRINTRGCKEY-------HVQFFGSVPE 403

  Fly  1109 NAGAQS------LLNNSFDAKKNKKKDLFEDVLRQADTVSKVERI----NVFERKSGRVITGHMA 1163
            .|....      ...|.||       :|..:.||::...::.:::    :..||....|..||..
Zfish   404 RAWIHEKRTVVYKSENQFD-------ELQAETLRKSTNPTEKQKLLKPQSQKERAQWEVGVGHAE 461

  Fly  1164 PSAHQFRKWLQENPSFEVL---PSGTVQSADAEKRLLKGAPEAATST-SEPAVLGVAKKPPEGPA 1224
            .:....|:...||.:|..:   |....::|.|.......||.|.|.| :.|.  ..||..||...
Zfish   462 AALQMTREERNENYTFIYIDKEPGADAETAAAPAPAPDSAPTAPTDTVTSPK--ATAKNRPERKQ 524

  Fly  1225 KLS--------HPQNTTVQASHQLGISSVRPL--------AKKDKEKTTPTVQAPTPNRIAAGKP 1273
            :.|        .|.....|...|..::||...        |.:.::..:|...||.|..   ..|
Zfish   525 RRSRGSAGAKEEPIPRRQQPRRQCSMNSVGETSSPNQGEDAMEQEQPCSPPKPAPRPKE---PSP 586

  Fly  1274 EPVRIGIRRSLREQLLARIKEAQAAEENSGQPTTQWPTVLEVDQFVKNVELEMFNSFGRDVGAKY 1338
            .|||...|.:...:||.                      |.:.....|||:
Zfish   587 PPVRTPWRTAAARKLLP----------------------LSITMKKLNVEI-------------- 615

  Fly  1339 KAKYRSLMFNIKDRKNRTLFEKICAKQVEPRQLVRMTPEQLASQELAKWREEENRHQLDMIKKSE 1403
                      ||           |..|: |:|.|          ||.|..|.|.|
Zfish   616 ----------IK-----------CDWQL-PKQKV----------ELPKKTESEER---------- 638

  Fly  1404 LDLLACAQNYVVKTHKGEEVIATKVDVTLPEENVSEASSMADTKQTSLVSEPSTSTLERSTSREK 1468
                   .:..||:.:|....|.....:..||..:..|..:|.:.||         .|:||.|::
Zfish   639 -------PSSRVKSPEGSSNKAEAETCSSEEERAASPSGWSDQEHTS---------AEQSTERKQ 687

  Fly  1469 AGSSKEKRHKSHKHHHRKRSRSRSNSRGRSVD----KRHRRQHNE--------GGEQPGSGEREH 1521
                           .|:..||||.|. :||:    |:.:::..|        .|.|.|:.|...
Zfish   688 ---------------QRRSVRSRSESE-KSVEPVPKKKVKKEQAETAPQMDFKTGSQKGASEISD 736

  Fly  1522 RSREKQSRER---DEIVPSPLPKKRDENDQSPV--PKKTAEKKTEASA 1564
            ..:..:.|.|   |..:.|.|.:...::|...:  |:....|::::.|
Zfish   737 SCKPLKKRSRASTDVEMASSLYRDTSDSDSRGLNDPQTGFGKRSDSPA 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pps	NP_001247075.1	TNG2	<827..965	CDD:227367	25/137 (18%)
		PHD_PHF3_like	914..963	CDD:277027	6/48 (13%)
		BRK	1142..1186	CDD:197800	10/50 (20%)
		TFIIS_M	1274..1396	CDD:284835	23/121 (19%)
		SPOC	1623..1729	CDD:285043
nsd3	XP_005155379.1	PWWP	351..468	CDD:321985	23/135 (17%)
		PHD1_NSD3	813..856	CDD:277119
		PHD_SF	861..907	CDD:328929
		PHD3_NSD3	908..960	CDD:277125
		PHD4_NSD3	1033..1066	CDD:277128
		WHSC1_related	1072..1165	CDD:99899
		AWS	1208..1258	CDD:197795
		SET	1259..1382	CDD:214614
		PHD5_NSD3	1437..1479	CDD:277131
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030