DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5196 and AKR2

DIOPT Version :9

Sequence 1:	NP_650191.1	Gene:	CG5196 / 41522	FlyBaseID:	FBgn0038039	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_014677.1	Gene:	AKR2 / 854199	SGDID:	S000005560	Length:	749	Species:	Saccharomyces cerevisiae

Alignment Length:	279	Identity:	59/279 - (21%)
Similarity:	101/279 - (36%)	Gaps:	67/279 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 FLLLSTLATFNYVMATLTGPGLMP------------KQWHPKDPKDAQFLQYCKKCEGYKAPRSH 105
            ||:.|.|....::....:.||.:.            ||.......|.:  .:|.:....|..||.
Yeast   398 FLVTSFLTVVLFLRLVRSDPGCLKTDDSLTSIQETIKQLIDLGKFDRE--NFCVETLERKPLRSK 460

  Fly   106 HCRKCDRCVKKMDHHCPWINHCVGWANHAYFTYF--------LLFSILGSLQGTVVLCCSFWRGI 162
            :.......|.:.||:||||.:.||..||..|.:|        .||         :.||.::::..
Yeast   461 YSFFSGALVARYDHYCPWIYNDVGLKNHKLFVFFAVTVQYHMFLF---------MWLCLAYFKKT 516

  Fly   163 YRYYYLTHGLAHLASVQFTLLSIIMC----------ILGMGLAIGVVIGLSMLLFIQLKTIVNNQ 217
            ...|......|..|    .|.:..:|          .|.:.:::. .|.|..:|.:|...|:...
Yeast   517 NYIYEQVEEYARCA----LLKNETLCKGSNYDPSTFFLFIWISVN-FIWLGAMLIVQFFQILKGI 576

  Fly   218 TGIEIWIVEKAIYR-RYRNADCDDEFLYPYDLGWRANLRLVFNDECQKRGDGIEWP--VVEGCDQ 279
            |..|::|:.|..:: ::.|       |.|::       ..::..|.:    |:|..  :.||...
Yeast   577 TTPELFILIKEEHKAKFIN-------LIPFE-------NSIYTSESK----GVEDSDMIPEGPSA 623

  Fly   280 YTLTREQLAQKEEKRARTR 298
            .|:|........|.|.|.|
Yeast   624 TTITHTISIDGLEPRNRRR 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5196	NP_650191.1	zf-DHHC	89..223	CDD:279823	34/151 (23%)
AKR2	NP_014677.1	ANKYR	1..195	CDD:223738
		ANK repeat	54..81	CDD:293786
		ANK repeat	83..115	CDD:293786
		ANK repeat	117..148	CDD:293786
		ANK repeat	189..220	CDD:293786
		Ank_4	190..243	CDD:372654
		ANK repeat	222..247	CDD:293786
		COG5273	340..711	CDD:227598	59/279 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810