DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5196 and AKR1

DIOPT Version :9

Sequence 1:	NP_650191.1	Gene:	CG5196 / 41522	FlyBaseID:	FBgn0038039	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_010550.1	Gene:	AKR1 / 851857	SGDID:	S000002672	Length:	764	Species:	Saccharomyces cerevisiae

Alignment Length:	393	Identity:	77/393 - (19%)
Similarity:	144/393 - (36%)	Gaps:	107/393 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 TTLYMNSMWW----PPNKSFAGFAHQALFLLLSTLATFNYVMATLT--GPGLMPKQWHPKDPKD- 86
            |.|::..:|:    |  ::|:...:..:.:|:..::.| |:...|.  .||.:|::...::.:.
Yeast   395 TLLWVTIVWFFKVMP--RTFSDEQYTNILMLVILVSVF-YLFGQLVIMDPGCLPEETDHENVRQT 456

  Fly    87 -AQFLQ--------YCKKCEGYKAPRSHHCRKCDRCVKKMDHHCPWINHCVGWANHAYFTYFL-- 140
             :..|:        :|.:....|..||......:..|.:.||:||||.:.||..||..|.:|:
Yeast   457 ISNLLEIGKFDTKNFCIETWIRKPLRSKFSPLNNAVVARFDHYCPWIFNDVGLKNHKAFIFFITL 521

  Fly   141 ----LFSILGSLQGTVVLCCSFWRGIYRYYYLTH---------GLAHLAS----VQFTLLSIIMC 188
                :|:.|       .||..::..:...:..|.         |.:.|.|    .:|..|.::..
Yeast   522 MESGIFTFL-------ALCLEYFDELEDAHEDTSQKNGKCFILGASDLCSGLIYDRFVFLILLWA 579

  Fly   189 ILGMGLAIGVVIGLSMLLFIQLKTIVNNQTGIEIWIVEKAIYRRYRNADCDDEFLYPYDLGWRAN 253
            :|..       |.::.|:|:|...|....|..|..::.|           :.:.:.|..|.:..|
Yeast   580 LLQS-------IWVASLIFVQAFQICKGMTNTEFNVLMK-----------ESKSIGPDGLSFNEN 626

  Fly   254 LRLVFN----------DECQKRGDGIEWPV-----------------VEGCDQY-TLTREQLAQK 290
                ||          |..::..|.:..||                 |.|.||: .:.:|.:..|
Yeast   627 ----FNTTPEGFAPSIDPGEESNDTVLAPVPGSTIRKPRTCFGVCYAVTGMDQWLAVIKETIGIK 687

  Fly   291 EE---------KRARTRTFKCTRPVTGRWL--PIFSQGWRVCVAAPCSDEPRISLRPNDMIKVTR 344
            :.         .|..| .:...|.|...||  .|.:..||..:..|...:..::....|..|:.:
Yeast   688 DSTGHNVYSITSRIPT-NYGWKRNVKDFWLTSDINAPLWRRILYPPSGSKALLNGIEVDYFKLYK 751

  Fly   345 FRN 347
            ..|
Yeast   752 LPN 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5196	NP_650191.1	zf-DHHC	89..223	CDD:279823	36/160 (23%)
AKR1	NP_010550.1	ANK repeat	75..101	CDD:293786
		ANKYR	78..270	CDD:223738
		ANK repeat	103..140	CDD:293786
		ANK repeat	142..173	CDD:293786
		ANK repeat	213..244	CDD:293786
		ANK repeat	246..271	CDD:293786
		COG5273	363..725	CDD:227598	71/362 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810