DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5196 and Zdhhc6

DIOPT Version :9

Sequence 1:	NP_650191.1	Gene:	CG5196 / 41522	FlyBaseID:	FBgn0038039	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001028745.1	Gene:	Zdhhc6 / 66980	MGIID:	1914230	Length:	413	Species:	Mus musculus

Alignment Length:	417	Identity:	160/417 - (38%)
Similarity:	234/417 - (56%)	Gaps:	29/417 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ISGFRRFLHWGPITALSIIKCITLTTLYMNSMWWPPNKSFAGFAHQALFLLLSTLATFNYVMATL 69
            :...||..|||||.||.:|...:...:..:.:|:.|..:..|..:..:.:..:.:..:||..|..
Mouse    13 LQDLRRLCHWGPIIALGVIAICSTMAMIDSVLWYWPLHTTGGSVNFIMLINWTVMILYNYFNAMF 77

  Fly    70 TGPGLMPKQWHPKDPKDAQFLQYCKKCEGYKAPRSHHCRKCDRCVKKMDHHCPWINHCVGWANHA 134
            .|||.:|:.|.|:..:|:.:|||||.|:.||||||||||||:|||.||||||||||:|.|..|||
Mouse    78 AGPGFVPRGWKPEKSQDSMYLQYCKVCQAYKAPRSHHCRKCNRCVMKMDHHCPWINNCCGHQNHA 142

  Fly   135 YFTYFLLFSILGSLQGTVVLCCSFWRGIYR---YYYLTHGLAHLAS-------VQFTLLSIIMCI 189
            .||.|||.:.||......:...:.:..:|.   :.:.|..:...|:       |.|.|.:....:
Mouse   143 SFTLFLLLAPLGCTHAAFIFVMTMYTQLYNRLSFGWNTVKIDMSAARRDPPPIVPFGLAAFAATL 207

  Fly   190 LGMGLAIGVVIGLSMLLFIQLKTIVNNQTGIEIWIVEKAIYRRYRNADCDDEFLYPYDLG--WRA 252
            ..:|||:|..|.:.||.|||:|.|:.|:|.||.||.||| ..|.:....|:.|::|||:|  |:
Mouse   208 FALGLALGTTIAVGMLFFIQIKIILRNKTSIESWIEEKA-KDRIQYYQLDEVFIFPYDMGSKWK- 270

  Fly   253 NLRLVFNDECQKRGDGIEWPVVEGCDQYTLTREQLAQKEEKRARTRTFKCTRPVTGRWLPIFSQG 317
            |.:.||.......|||:|||:.||||||:||.|||.||.:||.|:..:|......|...|: ::|
Mouse   271 NFKQVFTWSGVPEGDGLEWPIREGCDQYSLTIEQLKQKADKRVRSVRYKVIEDYNGACCPL-NRG 334

  Fly   318 WRVCVAAPCSDEPRISLRPNDMIKVTRFRNHWLFGERVLSEQELAGVKKRQRKGPIRGWFPRRSA 382
            .|....:||::||||.|:..:.|..||...:||:|:::|.:..:.|..:      :||||||
Mouse   335 VRTFFTSPCTEEPRIRLQKGEFILATRGLRYWLYGDKILDDSFIEGTSR------VRGWFPR--- 390

  Fly   383 VEVIEAVHEGSGDGNSETPAPAAQNGN 409
                ..|.:...||:|: |||..:..|
Mouse   391 ----NCVEKCPCDGDSD-PAPEGEKKN 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5196	NP_650191.1	zf-DHHC	89..223	CDD:279823	65/143 (45%)
Zdhhc6	NP_001028745.1	DHHC	95..241	CDD:366691	65/145 (45%)
		SH3_2	317..396	CDD:369452	27/92 (29%)
		Di-lysine motif. /evidence=ECO:0000250\|UniProtKB:Q9H6R6	410..413		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842484
Domainoid	1	1.000	136	1.000	Domainoid score	I4898
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41487
Inparanoid	1	1.050	307	1.000	Inparanoid score	I2602
Isobase	1	0.950	-	0	Normalized mean entropy	S2699
OMA	1	1.010	-	-		QHG52433
OrthoDB	1	1.010	-	-		D1491968at2759
OrthoFinder	1	1.000	-	-		FOG0006604
OrthoInspector	1	1.000	-	-		otm43052
orthoMCL	1	0.900	-	-		OOG6_103912
Panther	1	1.100	-	-	LDO	PTHR22883
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3273
SonicParanoid	1	1.000	-	-		X3745
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750