DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5196 and ZDHHC13

DIOPT Version :9

Sequence 1:	NP_650191.1	Gene:	CG5196 / 41522	FlyBaseID:	FBgn0038039	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_061901.2	Gene:	ZDHHC13 / 54503	HGNCID:	18413	Length:	622	Species:	Homo sapiens

Alignment Length:	303	Identity:	71/303 - (23%)
Similarity:	110/303 - (36%)	Gaps:	75/303 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 TTLYMNSMWWP---------PNKSFAGFAHQALFLLLSTLATFNYVMATLTGPGLMPKQWHPK-- 82
            |...::|::|.         |:.:.|.|....:|.:::.|..|....|  |.||........|
Human   349 TAFLLSSVFWIFMTWFILFFPDLAGAPFYFSFIFSIVAFLYFFYKTWA--TDPGFTKASEEEKKV 411

  Fly    83 ------DPKDAQFLQYCKKCEGYKAPRSHHCRKCDRCVKKMDHHCPWINHCVGWANHAYFTYFLL 141
                  :.....|..:|..|...|..||.||..|:.||.:.|.||.|...|:|:.||.|:.:||.
Human   412 NIITLAETGSLDFRTFCTSCLIRKPLRSLHCHVCNCCVARYDQHCLWTGRCIGFGNHHYYIFFLF 476

  Fly   142 FSILGSLQGTVVL---------CCSFWR--GIYRY------------YYLTHGLAHLASVQFTLL 183
            |  |..:.|.::.         |.:.::  |::.|            |.|.....|.:...|.||
Human   477 F--LSMVCGWIIYGSFIYLSSHCATTFKEDGLWTYLNQIVACSPWVLYILMLATFHFSWSTFLLL 539

  Fly   184 SIIMCILGMGLAIGVVIGLSMLLFIQLKTIVNNQTGIEIWIVEKAIYRRYRNADCDDEFLYPYDL 248
            :.:..|..:||.....|.|........:|:...:|                          ||:|
Human   540 NQLFQIAFLGLTSHERISLQKQSKHMKQTLSLRKT--------------------------PYNL 578

  Fly   249 GWRANLRLVFNDECQKRGDGIEWP-VVEGCDQYTLTREQLAQK 290
            |:..||...|...|    .|:..| ||:...|||:......:|
Human   579 GFMQNLADFFQCGC----FGLVKPCVVDWTSQYTMVFHPAREK 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5196	NP_650191.1	zf-DHHC	89..223	CDD:279823	41/156 (26%)
ZDHHC13	NP_061901.2	ANK 1. /evidence=ECO:0000250\|UniProtKB:Q8IUH5	43..78
		ANK	79..192	CDD:238125
		ANK repeat	81..112	CDD:293786
		ANK 2. /evidence=ECO:0000255	81..110
		ANK repeat	114..146	CDD:293786
		ANK 3. /evidence=ECO:0000255	115..144
		ANKYR	<145..271	CDD:223738
		ANK repeat	148..179	CDD:293786
		ANK 4. /evidence=ECO:0000255	148..177
		ANK repeat	181..247	CDD:293786
		ANK 5. /evidence=ECO:0000255	181..211
		ANK 6. /evidence=ECO:0000255	216..245
		ANK 7. /evidence=ECO:0000255	249..277
		zf-DHHC	423..559	CDD:307600	38/137 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810