DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5196 and Zdhhc17

DIOPT Version :9

Sequence 1:	NP_650191.1	Gene:	CG5196 / 41522	FlyBaseID:	FBgn0038039	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001034429.1	Gene:	Zdhhc17 / 366889	RGDID:	1595790	Length:	622	Species:	Rattus norvegicus

Alignment Length:	292	Identity:	74/292 - (25%)
Similarity:	121/292 - (41%)	Gaps:	62/292 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LYMNSMWWPPNKSFAGFAHQALFL------LLSTLATF-NYVMATLTGPGLMPKQWHPKDPKDAQ 88
            :|:.:.:|.....|..|.:...||      |.:::|.| |:..:..:.||::......|.....:
  Rat   352 IYLATKFWMYVTWFFWFWNDLSFLSIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVE 416

  Fly    89 FLQ--------YCKKCEGYKAPRSHHCRKCDRCVKKMDHHCPWINHCVGWANHAYF---TYFLLF 142
            ..:        :|..|...|..||.||..|:||:.|.||||||:.:||...||.||   .:||||
  Rat   417 LAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVCAGNHRYFMGYLFFLLF 481

  Fly   143 SILGSLQGTVVLCCSFW----------RGIYRYYYLTHGLAHLASVQFTLLSIIMC---ILGMGL 194
            .|...:.|    |.|:|          .|.:.|                :..|..|   :..|.|
  Rat   482 MICWMIYG----CVSYWGLHCETTYTKDGFWTY----------------ITQIATCSPWMFWMFL 526

  Fly   195 -AIGVVIGLSMLLFIQLKTIVNNQTGIEIWIVEKAIYRRYRNADCDDEFL-YPYDLGWRANLRLV 257
             ::...:.:::||..|:..|    |.:.|...|:...|||::.......: .|::.|...|:...
  Rat   527 NSVFHFMWVAVLLMCQMYQI----TCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVRNIIDF 587

  Fly   258 FNDECQKRGDGIEWPV-VEGCDQYTLTREQLA 288
            |...|    .|:..|| |:...|||:..:|::
  Rat   588 FEFRC----CGLFRPVIVDWTRQYTIEYDQIS 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5196	NP_650191.1	zf-DHHC	89..223	CDD:279823	43/158 (27%)
Zdhhc17	NP_001034429.1	Necessary and sufficient for interaction with DNAJC5 and SNAP25. /evidence=ECO:0000250\|UniProtKB:Q80TN5	1..295
		Ank_4	<60..100	CDD:290365
		ANK	77..192	CDD:238125
		ANK repeat	79..110	CDD:293786
		Ank_2	84..177	CDD:289560
		ANK repeat	112..144	CDD:293786
		ANK	143..267	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_2	151..245	CDD:289560
		ANK repeat	179..211	CDD:293786
		ANK repeat	214..245	CDD:293786
		zf-DHHC	428..558	CDD:279823	45/153 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810