DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5196 and Zdhhc6

DIOPT Version :9

Sequence 1:	NP_650191.1	Gene:	CG5196 / 41522	FlyBaseID:	FBgn0038039	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001032741.1	Gene:	Zdhhc6 / 361771	RGDID:	1304657	Length:	413	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	161/417 - (38%)
Similarity:	236/417 - (56%)	Gaps:	29/417 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ISGFRRFLHWGPITALSIIKCITLTTLYMNSMWWPPNKSFAGFAHQALFLLLSTLATFNYVMATL 69
            :...||..|||||.||.:|...:...:..:.:|:.|..:..|..:..:.:..:.:..:||..|..
  Rat    13 LQDLRRLCHWGPIIALGVIAICSTMAMIDSVLWYWPLHTTGGSVNFIMLINWTVMILYNYFNAMF 77

  Fly    70 TGPGLMPKQWHPKDPKDAQFLQYCKKCEGYKAPRSHHCRKCDRCVKKMDHHCPWINHCVGWANHA 134
            .|||.:|:.|.|::|:|:.:|||||.|:.||||||||||||:|||.||||||||||:|.|..|||
  Rat    78 AGPGFVPRGWKPENPQDSMYLQYCKVCQAYKAPRSHHCRKCNRCVMKMDHHCPWINNCCGHQNHA 142

  Fly   135 YFTYFLLFSILGSLQGTVVLCCSFWRGIYR---YYYLTHGLAHLAS-------VQFTLLSIIMCI 189
            .||.|||.:.||......:...:.:..:|.   :.:.|..:...|:       |.|.|.:....:
  Rat   143 SFTLFLLLAPLGCTHAAFIFVMTMYTQLYNRLSFGWNTVKIDMSAARRDPPPIVPFGLAAFAATL 207

  Fly   190 LGMGLAIGVVIGLSMLLFIQLKTIVNNQTGIEIWIVEKAIYRRYRNADCDDEFLYPYDLG--WRA 252
            ..:|||:|..|.:.||.|||:|.|:.|:|.||.||.||| ..|.:....|:.|::|||:|  |:
  Rat   208 FALGLALGTTIAVGMLFFIQIKIILRNKTSIESWIEEKA-KDRIQYYQLDEVFVFPYDMGSKWK- 270

  Fly   253 NLRLVFNDECQKRGDGIEWPVVEGCDQYTLTREQLAQKEEKRARTRTFKCTRPVTGRWLPIFSQG 317
            ||:.||.......|||:|||:.|||.||:||.|||.||.:||.|:..:|......|...|: ::|
  Rat   271 NLKQVFTWSGVPEGDGLEWPIREGCHQYSLTIEQLKQKADKRVRSVRYKVVEDYNGACCPL-NRG 334

  Fly   318 WRVCVAAPCSDEPRISLRPNDMIKVTRFRNHWLFGERVLSEQELAGVKKRQRKGPIRGWFPRRSA 382
            .|....:||::||||.|:..:::..||...:||:|:::|.:..:.|..:      |||||||
  Rat   335 VRTFFTSPCTEEPRIQLQKGELVLATRGLRYWLYGDKILDDSFIEGTSR------IRGWFPR--- 390

  Fly   383 VEVIEAVHEGSGDGNSETPAPAAQNGN 409
                ..|.:...||.|: |||..:..|
  Rat   391 ----NCVEKCPCDGESD-PAPEGEKKN 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5196	NP_650191.1	zf-DHHC	89..223	CDD:279823	65/143 (45%)
Zdhhc6	NP_001032741.1	DHHC	95..241	CDD:396215	65/145 (45%)
Zdhhc6	NP_001032741.1	SH3_2	317..394	CDD:400139	26/90 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345933
Domainoid	1	1.000	131	1.000	Domainoid score	I5024
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41487
Inparanoid	1	1.050	306	1.000	Inparanoid score	I2552
OMA	1	1.010	-	-		QHG52433
OrthoDB	1	1.010	-	-		D1491968at2759
OrthoFinder	1	1.000	-	-		FOG0006604
OrthoInspector	1	1.000	-	-		otm45115
orthoMCL	1	0.900	-	-		OOG6_103912
Panther	1	1.100	-	-	LDO	PTHR22883
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3745
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810