DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5196 and zdhhc6

DIOPT Version :9

Sequence 1:	NP_650191.1	Gene:	CG5196 / 41522	FlyBaseID:	FBgn0038039	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001191086.1	Gene:	zdhhc6 / 324468	ZFINID:	ZDB-GENE-030131-3189	Length:	412	Species:	Danio rerio

Alignment Length:	405	Identity:	158/405 - (39%)
Similarity:	232/405 - (57%)	Gaps:	28/405 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RRFLHWGPITALSIIKCITLTTLYMNSMWWPPNKSFAGFAHQALFLLLSTLATFNYVMATLTGPG 73
            :|..|||||.||::|...:...:..:.:|:.|..:..|..:..:.:..:.|..:||..|...|||
Zfish    17 KRLFHWGPIIALTVIGVCSSMAILDSIIWYWPLDTTGGSINFIMLINWTVLILYNYFNAMFVGPG 81

  Fly    74 LMPKQWHPKDPKDAQFLQYCKKCEGYKAPRSHHCRKCDRCVKKMDHHCPWINHCVGWANHAYFTY 138
            .:|.:|.|:..:|..:||:|:.|:|||||||||||||:|||.||||||||||:|.|..||||||.
Zfish    82 YIPLEWKPEKQQDIMYLQFCRLCQGYKAPRSHHCRKCNRCVMKMDHHCPWINNCCGHLNHAYFTS 146

  Fly   139 FLLFSILGSLQGTVVLCCSFWRGIYRYYYLTHGLA------------HLASVQFTLLSIIMCILG 191
            |||.:.||.:...::...:.:..:|.  .::.|.:            |...:.|::.:....:..
Zfish   147 FLLLAPLGCIHAALIFIMTMYTQLYD--RISFGWSSVKIDMSAARHIHHPIMPFSIAAFAATLFA 209

  Fly   192 MGLAIGVVIGLSMLLFIQLKTIVNNQTGIEIWIVEKAIYRRYRNADCDDEFLYPYDLGWR-ANLR 255
            :|||:|..|.:.||.|||:|.|:.|:|.||.||.||| ..|.:.....::|::|||||.| .|.:
Zfish   210 LGLALGTTIAVGMLFFIQMKVILRNRTSIEAWIEEKA-KDRIQYYQTGEDFIFPYDLGSRWENFK 273

  Fly   256 LVFNDECQKRGDGIEWPVVEGCDQYTLTREQLAQKEEKRARTRTFKCTRPVTGRWLPIFSQGWRV 320
            .||.......||||||||.|.|||||||.|||.||.:||.|:..::......|...|: .:|...
Zfish   274 QVFTWSGAPMGDGIEWPVHEKCDQYTLTIEQLKQKHDKRQRSVEYRVVEEYNGACCPL-GKGLNT 337

  Fly   321 CVAAPCSDEPRISLRPNDMIKVTRFRNHWLFGERVLSEQEL-AGVKKRQRKGPIRGWFPRRSAVE 384
            ....||::||||.|...:.|..||....|::|::||:|::. |||:       ||||||||.
Zfish   338 FFRTPCTEEPRIKLTKGETIFATRGTKWWMYGDKVLNEEQAKAGVR-------IRGWFPRRC--- 392

  Fly   385 VIEAVHEGSGDGNSE 399
            |.:.:::.:.:..||
Zfish   393 VEKCLYDSANNSTSE 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5196	NP_650191.1	zf-DHHC	89..223	CDD:279823	63/145 (43%)
zdhhc6	NP_001191086.1	DHHC	95..241	CDD:396215	63/147 (43%)
zdhhc6	NP_001191086.1	Di-lysine motif. /evidence=ECO:0000250\|UniProtKB:Q9H6R6	409..412
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586914
Domainoid	1	1.000	141	1.000	Domainoid score	I4667
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41487
Inparanoid	1	1.050	304	1.000	Inparanoid score	I2634
OMA	1	1.010	-	-		QHG52433
OrthoDB	1	1.010	-	-		D1491968at2759
OrthoFinder	1	1.000	-	-		FOG0006604
OrthoInspector	1	1.000	-	-		otm24554
orthoMCL	1	0.900	-	-		OOG6_103912
Panther	1	1.100	-	-	LDO	PTHR22883
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3273
SonicParanoid	1	1.000	-	-		X3745
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840