DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5196 and ZDHHC20

DIOPT Version :9

Sequence 1:	NP_650191.1	Gene:	CG5196 / 41522	FlyBaseID:	FBgn0038039	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001316988.1	Gene:	ZDHHC20 / 253832	HGNCID:	20749	Length:	365	Species:	Homo sapiens

Alignment Length:	339	Identity:	76/339 - (22%)
Similarity:	131/339 - (38%)	Gaps:	102/339 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RRFLHWGPITALSIIKC---------ITLTTLYMNSMWWPPNKSFAGFAHQALFLLLSTLATFNY 64
            :|.:.|.|:..::.:..         :.:.|::.|      .::.....:...|.|...:..::|
Human    11 QRVVGWVPVLFITFVVVWSYYAYVVELCVFTIFGN------EENGKTVVYLVAFHLFFVMFVWSY 69

  Fly    65 VMATLTGPGLMPKQWH----PKDPKDAQF--------------------------LQYCKKCEGY 99
            .|...|.|....|:::    .|:..:.:|                          ::||:||:..
Human    70 WMTIFTSPASPSKEFYLSNSEKERYEKEFSQERQQEILRRAARALPIYTTSASKTIRYCEKCQLI 134

  Fly   100 KAPRSHHCRKCDRCVKKMDHHCPWINHCVGWANHAYFTYFLLFSILGSLQGTVVLCCSFWRGIYR 164
            |..|:|||..||.|:.||||||||:|:|||::|:.:|..|||:|:         |.|.|......
Human   135 KPDRAHHCSACDSCILKMDHHCPWVNNCVGFSNYKFFLLFLLYSL---------LYCLFVAATVL 190

  Fly   165 YYYLTHGLAHLAS--VQFTLLSIIMCILGMGLAIGVVIGLSMLLFIQLKTIVNNQTGIEIWIVEK 227
            .|::......|..  .:|.:|.:..              :|.:.||.:.::.:    ...|:|.|
Human   191 EYFIKFWTNELTDTRAKFHVLFLFF--------------VSAMFFISVLSLFS----YHCWLVGK 237

  Fly   228 AIYRRYRNADCDDEFLYP----------YDLGWRANLRLVFNDE--------CQKRGDGIEWPV- 273
                   |....:.|..|          :.||...|.|.||.||        ....|||..:|.
Human   238 -------NRTTIESFRAPTFSYGPDGNGFSLGCSKNWRQVFGDEKKYWLLPIFSSLGDGCSFPTR 295

  Fly   274 VEGCD--QYTLTRE 285
            :.|.|  |.::|.:
Human   296 LVGMDPEQASVTNQ 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5196	NP_650191.1	zf-DHHC	89..223	CDD:279823	41/161 (25%)
ZDHHC20	NP_001316988.1	zf-DHHC	16..301	CDD:327686	72/324 (22%)
ZDHHC20	NP_001316988.1	Substrate binding. /evidence=ECO:0000305\|PubMed:29326245	140..143		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1491968at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820