DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sccpdh2 and sccpdha.2

DIOPT Version :9

Sequence 1:	NP_650190.1	Gene:	Sccpdh2 / 41521	FlyBaseID:	FBgn0038038	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_001107908.2	Gene:	sccpdha.2 / 569379	ZFINID:	ZDB-GENE-080212-12	Length:	427	Species:	Danio rerio

Alignment Length:	432	Identity:	172/432 - (39%)
Similarity:	254/432 - (58%)	Gaps:	31/432 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IIFGASGFTGKYTVFEAVSVLK-----GLQWGIAGRNQEKLQSVLREMGAK-SKTDL-SQTPIVI 66
            ||||||||||::.|.|......     .|:|.:|||::.||:.|:.:..|. ||.:| ::..|::
Zfish    15 IIFGASGFTGQFVVEEVSRCASEGPNGSLKWAVAGRSKSKLEKVIEQASANLSKPELKTEVDIIV 79

  Fly    67 ADVNNEASLLEMAKRCRILVNTAGPYRFFGERVVRACIEAGTHHVDVSGEPQYMETMQLRYHDLA 131
            |||:::.||..|.|:..|:::..||||||||.||::|:|.|.|.:|:|||||::|.|||.|||.|
Zfish    80 ADVSDQESLAAMCKQAVIVLSCVGPYRFFGESVVKSCVENGAHCLDISGEPQFLEGMQLNYHDQA 144

  Fly   132 KERGVYVISACGFDSIPADMGVTFVEKNFDGVVNSVENFVHLGVKGGTKGTGSAALNTGTWESAI 196
            .::|||::.:||||||||||||.:....|.|.:.:|::|:.||     .|.....||.|||:|||
Zfish   145 ADKGVYIVGSCGFDSIPADMGVIYTRDQFKGTLTAVDSFLTLG-----SGPEGGCLNDGTWQSAI 204

  Fly   197 HAIANRSESVAIRRKLFPERLPNFHPALKSRSPLSRAAEVDNKVILPFPETDRSVVMRSQRFLYE 261
            :.:|::.:...:|:|...:.|....|.:|.:..|..::||....| ||..||.|||.|:||:|:|
Zfish   205 YGLADKGKLKTLRKKFGHKPLLVVGPKIKRKGLLFYSSEVQQYAI-PFMGTDPSVVKRTQRYLHE 268

  Fly   262 LEKKRPVQMQAYMTYPSWFAASVVVLFASIIG-----IMAKFSFGRQLLLKYPTVFSGGMASREG 321
            ...:.|||..||..     ...:..:|..:||     ::|..|.||:||:|||..||.|:.|.||
Zfish   269 ELNETPVQYGAYAG-----IGGISNVFKFLIGGFMFCLLALCSCGRKLLIKYPGFFSFGLFSTEG 328

  Fly   322 PSEARMERSFFRMTMKATGWPKSEKLAETTDQYTSPPTKTLTVRVTGPNPGYGSTCVALLSTAKT 386
            |::.::|.:.|.......|:      .|..|.....|...:...|.||..||.:|.:.::..|.|
Zfish   329 PTKKQIEDASFHFICLGDGY------TEGQDPSKGKPNGKIRTEVKGPEIGYVTTPITMVQAAIT 387

  Fly   387 ILNESDKMPGSGGVLPPGAAFRGTSLISELEKHEHGIKFEIV 428
            :|||.|.:|.:|||..|||.|..|:||..|.|  |||:|.::
Zfish   388 MLNEPDSLPQTGGVYTPGATFAKTTLIKRLNK--HGIEFSVI 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sccpdh2	NP_650190.1	COG3268	7..416	CDD:225807	166/418 (40%)
Sccpdh2	NP_650190.1	Sacchrp_dh_NADP	9..139	CDD:281434	64/136 (47%)
sccpdha.2	NP_001107908.2	COG3268	10..424	CDD:225807	171/427 (40%)
sccpdha.2	NP_001107908.2	Sacchrp_dh_NADP	14..152	CDD:281434	64/136 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590400
Domainoid	1	1.000	202	1.000	Domainoid score	I2937
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9334
Inparanoid	1	1.050	332	1.000	Inparanoid score	I2409
OMA	1	1.010	-	-		QHG56565
OrthoDB	1	1.010	-	-		D302978at33208
OrthoFinder	1	1.000	-	-		FOG0002586
OrthoInspector	1	1.000	-	-		mtm6482
orthoMCL	1	0.900	-	-		OOG6_101495
Panther	1	1.100	-	-	O	PTHR12286
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1697
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910