DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9f2 and CYP4F12

DIOPT Version :9

Sequence 1:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_076433.3	Gene:	CYP4F12 / 66002	HGNCID:	18857	Length:	524	Species:	Homo sapiens

Alignment Length:	470	Identity:	118/470 - (25%)
Similarity:	203/470 - (43%)	Gaps:	78/470 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 PLLMVRDPDLIKQITIKDFDHFINHRNVFATSSDDDPHDMSNLF--------GSSLFSMRDARWK 135
            |.:::..||.|:.||           |..|..:..|     |||        |..:......:|.
Human    97 PFIVLCHPDTIRSIT-----------NASAAIAPKD-----NLFIRFLKPWLGEGILLSGGDKWS 145

  Fly   136 DMRSTLSPAFTGSKMRQMFQLMNQVAKEAVD----CLKQDDSRVQENELDMKDYCTRFTNDVIAS 196
            ..|..|:|||..:.::....:.|:.|...:|    ...:..||     |||.::.:..|.|.:..
Human   146 RHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSR-----LDMFEHISLMTLDSLQK 205

  Fly   197 TAFGLQVNSFKDRENTFYQMGKKLTTFT------FLQSMKFMLFFALKG---------LNKILKV 246
            ..|... :..::|.:.:.....:|:...      .||.|.|:.:.:..|         ::.....
Human   206 CIFSFD-SHCQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDA 269

  Fly   247 ELFDRKSTQYFVRLVLDAMKYRQEHNIVRPDMINMLMEARGIIQTEKTKASAVREWSDRDIVAQC 311
            .:.:|:.| ...:.:.|..|.:.:...:  |.|::|:    :.:.|..||     .||.||.|:.
Human   270 VIRERRRT-LPTQGIDDFFKDKAKSKTL--DFIDVLL----LSKDEDGKA-----LSDEDIRAEA 322

  Fly   312 FVFFFAGFETSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGKELTYEAIMGMKYLDQVVNE 376
            ..|.|.|.:|:|..:.:..:.|..:.:.|:|..:|||::.:|.:.||:.::.:..:.:|...|.|
Human   323 DTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKE 387

  Fly   377 VLRKWPAAIAVDRECNKDITFDVDGQKVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDEN 441
            .||..|.|..:.|.|.:||... ||:  .:.||....:...|.|.:|..:.:|..:||.||..||
Human   388 SLRLHPPAPFISRCCTQDIVLP-DGR--VIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPEN 449

  Fly   442 KESIQPFTYFPFGLGQRNCIGSRFALLEAKAVIYYLLKDYRF-----APAKKSCIPLELITSGFQ 501
            .:...|..:.||..|.|||||..||:.|.|.|:..:|..:||     .|.:|    ||||
Human   450 SKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRK----LELI----- 505

  Fly   502 LSPKGGFWIKLVQRN 516
            :..:||.|:::...|
Human   506 MRAEGGLWLRVEPLN 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	116/462 (25%)
CYP4F12	NP_076433.3	p450	52..506	CDD:306555	114/454 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810