DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9f2 and Cyp3a25

DIOPT Version :9

Sequence 1:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_062766.2	Gene:	Cyp3a25 / 56388	MGIID:	1930638	Length:	503	Species:	Mus musculus

Alignment Length:	527	Identity:	172/527 - (32%)
Similarity:	277/527 - (52%)	Gaps:	53/527 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EFFALFAIAAALFYRWASANNDFFKDRGIAYEKPVLYFGNMAGMFLRKRAMFDIVCDLYTKGGSK 68
            |.:.|...:..|||.:.:.::..||..||...||:...|.:...:   ..|:....|.|.|.|
Mouse    10 ETWVLLVTSLVLFYIYGTYSHGLFKKLGIPGPKPLPLLGTIFNYY---DGMWKFDEDCYKKYG-- 69

  Fly    69 KFFGIFEQRQPLLMVRDPDLIKQITIKD-FDHFINHRNVFATSSDDDPHDMSNLFGSSLFSMR-- 130
            |.:|.:|..||:|.:.||::||.:.:|: :..|.|.|                .||...|..:
Mouse    70 KIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRR----------------FFGPVGFMKKAI 118

  Fly   131 ----DARWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENELDMKDYCTRFTN 191
                |..||.:|:.|||.||..|:::||.:|.|.....|..|::::.:.:  .:.|||....::.
Mouse   119 TISEDEEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGE--PISMKDIFGAYSM 181

  Fly   192 DVIASTAFGLQVNSFKDRENTFYQMGKKLTTF----TFLQSMKFMLFFALKGLNKILKVELFDRK 252
            |||..|:||:.|:|..:.::.|.|..||:..|    .||.|:  :||..|..:.::|...:|.|.
Mouse   182 DVITGTSFGVNVDSLNNPQDPFVQKAKKILKFKIFDPFLLSI--ILFPFLTPIYEMLNFSIFPRD 244

  Fly   253 STQYFVRLVLDAMKYRQEHNIV-RPDMINMLMEARGIIQTEKTKASAVREWSDRDIVAQCFVFFF 316
            |..:|.:.|....|.|...|.. |.|.:.::|..:.....|..||     .||.::.||..:|.|
Mouse   245 SMNFFKKFVKRMKKERLASNQKNRVDFLQLMMNTQNSKGQESQKA-----LSDLEMAAQAVIFIF 304

  Fly   317 AGFETSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGK-ELTYEAIMGMKYLDQVVNEVLRK 380
            .|::.::..:....:||..:.|||::|.:|   :|:.|..| .:||:|:|.|:|||.||||.||.
Mouse   305 GGYDATSTSISLIMYELATHPDVQKKLQDE---IDRTLPNKAPVTYDALMDMEYLDMVVNESLRL 366

  Fly   381 WPAAIAVDRECNKDITFDVDGQKVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESI 445
            :|.||.::|...||:  :::|  |.:.||.|:.:|....||:|:|:..|.:|.|||||.|||.:|
Mouse   367 YPIAIRLERVSKKDV--EING--VFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKENKGNI 427

  Fly   446 QPFTYFPFGLGQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSG-FQLSPKGGFW 509
            .|:.|.|||.|.|||||.||||:..|..:..:|:::...|.:::.|||::.... ||  |:....
Mouse   428 DPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQIPLKISREPIFQ--PEKPII 490

  Fly   510 IKLVQRN 516
            :|:|.|:
Mouse   491 LKVVSRD 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	160/487 (33%)
Cyp3a25	NP_062766.2	p450	39..493	CDD:278495	160/492 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2821
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.770