DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9f2 and Cyp4f1

DIOPT Version :9

Sequence 1:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_062569.2	Gene:	Cyp4f1 / 56266	RGDID:	70926	Length:	524	Species:	Rattus norvegicus

Alignment Length:	559	Identity:	121/559 - (21%)
Similarity:	221/559 - (39%)	Gaps:	110/559 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WEFFALFA---IAAALFYRWASANNDFFKDRGIAYEKPVLYFGNMAGMFLRKRAMFDIVCDLYTK 64
            |:...||.   |.|.:..:..:|..:|.:.||........:.....||...            |:
  Rat    19 WQTLLLFGASWILAQILTQIYAAYRNFRRLRGFPQPPKRNWLMGHVGMVTP------------TE 71

  Fly    65 GGSK---KFFGIFEQ--------RQPLLMVRDPDLIKQI-------TIKDFDHFINHRNVFATSS 111
            .|.|   :..|.:.|        ..|::.:...|:::.|       .:||.        :|.|.
  Rat    72 QGLKELTRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDV--------IFYTI- 127

  Fly   112 DDDPHDMSNLFGSSLFSMRDARWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRV- 175
                  :....|..|......:|...|..|:|||..:.::...::.|    ::.:.:.....|:
  Rat   128 ------LKPWLGDGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKIFN----DSTNIMHAKWKRLI 182

  Fly   176 --QENELDMKDYCTRFTNDVIASTAFGLQVNSFKDRENTFYQMGKKLTTFTFLQSMKFMLFFALK 238
              ..:.|||.::.:..|.|.:....|....|. :::.:.:.....:|:.....:..:.:||..|
  Rat   183 SEGSSRLDMFEHVSLMTLDSLQKCVFSFDSNC-QEKSSEYIAAILELSALVAKRHQQPLLFMDL- 245

  Fly   239 GLNKILKVELFDRKSTQYFVRLVLDAMKYRQEHNIVRPDMINMLMEAR------GIIQTEKTKAS 297
                              ...|..|.|::.:..|:|......::.|.|      |:.:..|:||.
  Rat   246 ------------------LYNLTPDGMRFHKACNLVHEFTDAVIRERRRTLPDQGLDEFLKSKAK 292

  Fly   298 AV----------------REWSDRDIVAQCFVFFFAGFETSAVLMCFTAHELMENQDVQQRLYEE 346
            :.                :|.||.||.|:...|.|.|.:|:|..:.:..:.|.::.:.|:|..:|
  Rat   293 SKTLDFIDVLLLTKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQE 357

  Fly   347 VQQVDQDLEGKELTYEAIMGMKYLDQVVNEVLRKWPAAIAVDRECNKDITFDVDGQKVEVKKGDV 411
            ||::.:|.:.:|:.::.:..:.:|...:.|.||..|....:.|.|.:||... ||:  .:.||.:
  Rat   358 VQELLRDRDPEEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLP-DGR--TIPKGII 419

  Fly   412 IWLPTCGFHRDPKYFENPMKFDPERFSDENKESIQPFTYFPFGLGQRNCIGSRFALLEAKAVIYY 476
            ..:...|.|.:|..:.:|..::|.||..||.:...|..:.||..|.|||||..||:.|.|..:..
  Rat   420 CLISIFGIHHNPSVWPDPEVYNPFRFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALAL 484

  Fly   477 LLKDYRFAPAKKSCIPL---ELITSGFQLSPKGGFWIKL 512
            .|..:|..|..|.  |.   |||     |..:||.|:::
  Rat   485 TLLRFRLLPDDKE--PRRQPELI-----LRAEGGLWLRV 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	111/519 (21%)
Cyp4f1	NP_062569.2	CYP4F	74..515	CDD:410772	108/489 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900