DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9f2 and Cyp3a73

DIOPT Version :9

Sequence 1:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	XP_038945885.1	Gene:	Cyp3a73 / 498198	RGDID:	1595705	Length:	504	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	171/525 - (32%)
Similarity:	274/525 - (52%)	Gaps:	48/525 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EFFALFAIAAALFYRWASANNDFFKDRGIAYEKPVLYFGNMAGMFLRKRAMFDIVCDLYTKGGSK 68
            |.:.|.||...||||:.:..:..||.:||...||:.:.|.:.. :.|....||:.|  |.|.|
  Rat    10 ETWLLLAIILVLFYRFGTRTHGIFKKQGIPGPKPLPFLGTVLN-YYRGLWKFDMEC--YKKCG-- 69

  Fly    69 KFFGIFEQRQPLLMVRDPDLIKQITIKD-FDHFINHRNVFATSSDDDPHDMSNLFGSSLFSMRDA 132
            |.:|:|:.:.|:..:.|.::||.:.:|: |..|.|.||:...          .:...|:...:|.
  Rat    70 KIWGLFDGQTPVFAIMDTEMIKSVLVKECFSVFTNRRNIGPV----------GIMSKSISVAKDE 124

  Fly   133 RWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENE-LDMKDYCTRFTNDVIAS 196
            .||..|:.|||.||..::::||.::.......|..|||   :|::.: |.||:....::.|||.|
  Rat   125 EWKRYRAFLSPTFTSGRLKEMFPIIEHYGDILVKYLKQ---KVEKGKPLAMKEVFGAYSMDVITS 186

  Fly   197 TAFGLQVNSFKDRENTFYQMGKKLTTFTFLQS--MKFMLFFALKGLNKILKVELFDRKSTQYFVR 259
            |:|.:.:||..:.::.|.:..||...|.|...  :..:||..|..:.::|.:.||.:.|..:|.:
  Rat   187 TSFEVNINSINNPKDPFVEKVKKFQRFDFFDPLFLSVVLFPFLTPIYEMLNICLFPKDSVAFFQK 251

  Fly   260 LV-------LDAMKYRQEHNIVRPDMINMLMEARGIIQTEKTKASAVREWSDRDIVAQCFVFFFA 317
            .|       ||:   :.:|   |.|.:.::|.|.   ...|.|.|. :..||.:||||..:|.||
  Rat   252 FVYRMKQTRLDS---KHKH---RVDFLQLMMNAH---NNSKDKVSH-KALSDIEIVAQAIIFIFA 306

  Fly   318 GFETSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGK-ELTYEAIMGMKYLDQVVNEVLRKW 381
            .:||::..:.|..:.|..:.|.|::|.||   :|:.|..| ..||:.:|.|:|||.|:||..|.:
  Rat   307 SYETTSSTLSFVLYSLATHPDSQKKLQEE---IDRALPNKAPPTYDTVMEMEYLDMVLNETPRLY 368

  Fly   382 PAAIAVDRECNKDITFDVDGQKVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESIQ 446
            |....::|.|.|||..|    .|.:.||.|:.:|......||:::..|.:|.|||||.|||.||.
  Rat   369 PIGYRLERVCKKDIKLD----GVFIPKGSVVMIPFYTLQHDPQHWPEPEEFLPERFSKENKGSID 429

  Fly   447 PFTYFPFGLGQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSGFQLSPKGGFWIK 511
            |:.|.|||.|.|||||.||||:..|..:..:|:::.|...:::.|||:|..... ..|:....:|
  Rat   430 PYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQLCEETQIPLKLSRQRL-FGPEKPIVLK 493

  Fly   512 LVQRN 516
            :|.|:
  Rat   494 VVPRD 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	156/485 (32%)
Cyp3a73	XP_038945885.1	CYP3A	67..493	CDD:410743	148/458 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010