DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9f2 and Cyp6a21

DIOPT Version :9

Sequence 1:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	168/511 - (32%)
Similarity:	277/511 - (54%)	Gaps:	26/511 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ALFAIAAALFYRWASANNDFFKDRGIAYEKPVLYFGNMAGMFLRKRAMFDIVCDLYTK-GGSKKF 70
            ||.|:...|..:|.|... .::|.||..|:|.:..|:|.|: ...|:..:|....|.| .||..|
  Fly    10 ALLALVGYLLMKWRSTMR-HWQDLGIPCEEPHILMGSMKGV-RTARSFNEIWTSYYNKFRGSGPF 72

  Fly    71 FGIFEQRQPLLMVRDPDLIKQITIKDFDHFINHRNVFATSSDDDPHDMSNLFGSSLFSMRDARWK 135
            .|.:..|:|.:.|.:..|.|||.||:|:.|.:..  |..:.:|||      ....||.:...:|:
  Fly    73 AGFYWFRRPAVFVLETSLAKQILIKEFNKFTDRG--FFHNPEDDP------LSGQLFLLDGQKWR 129

  Fly   136 DMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENELDMKDYCTRFTNDVIASTAFG 200
            .||:.||..||..||:.||..:.:||.|..|...|:.::  ...:::::...|||.|||.:.|||
  Fly   130 TMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAK--SPVVEVRELLARFTTDVIGTCAFG 192

  Fly   201 LQVNSFKDRENTFYQMGKKLTTFTFLQSMKFMLFFALKGLNKILKVELFDRKSTQYFVRLVLDAM 265
            ::.:|.||.:..|.:||::..|...|..:......:...|.:.|.:::......::|:|:|.:.:
  Fly   193 IECSSLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNLARRLHMKMTAEPIERFFMRIVRETV 257

  Fly   266 KYRQEHNIVRPDMINMLMEARG----IIQTEKTKASAVREWSDRDIVAQCFVFFFAGFETSAVLM 326
            .:|:::||.|.|.::.|::.:.    :.|:.::....:.|     |.||.||||.||||||:..|
  Fly   258 AFREQNNIRRNDFMDQLIDLKNKPLMVSQSGESVNLTIEE-----IAAQAFVFFAAGFETSSTTM 317

  Fly   327 CFTAHELMENQDVQQRLYEEVQQVDQDLEGKELTYEAIMGMKYLDQVVNEVLRKWPAAIAVDREC 391
            .|..:||.:|||:|.|:.:|.|:|.:...| ||.||::..:.||||||:|.||.:.....::|||
  Fly   318 GFALYELAQNQDIQNRVRKECQEVIEKCNG-ELNYESMKDLVYLDQVVSETLRLYTVLPVLNREC 381

  Fly   392 NKDITFDVDGQ-KVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESIQPFTYFPFGL 455
            .:|  ::|.|. |..:|||..:.:|....|||.|.:.||..|:|:.||.|..:......:.|||.
  Fly   382 LED--YEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGD 444

  Fly   456 GQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSGFQLSPKGGFWIK 511
            |.|||||.||..::|:..:..|:||::|:..:|:.||:......|.::...|.::|
  Fly   445 GPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKEMFLIASNSGIYLK 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	157/479 (33%)
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	158/482 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461231
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800