DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9f2 and Cyp6a13

DIOPT Version :9

Sequence 1:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	181/515 - (35%)
Similarity:	273/515 - (53%)	Gaps:	31/515 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLWEFFALFAIAAALF--YRWASANNDFFKDRGIAYEKPVLYFGNMAGMFLRKRAMFDIVCDLYT 63
            ||.....:|.:...|:  .||   :..::..||:|.|:||.:.|||:|:. |.....||...:|.
  Fly     1 MLTLLVLVFTVGLLLYVKLRW---HYSYWSRRGVAGERPVYFRGNMSGLG-RDLHWTDINLRIYR 61

  Fly    64 K-GGSKKFFGIFEQRQPLLMVRDPDLIKQITIKDFDHFINHRNVFATSSDDDPHDMSNLFGSSLF 127
            | .|.:::.|.|......|.:.|.:||:.|.|:||..|.: |.:|....||.      |.|:.||
  Fly    62 KFRGVERYCGYFTFMTKSLFIMDLELIRDIMIRDFSSFAD-RGLFHNVRDDP------LTGNLLF 119

  Fly   128 SMRDARWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENELDMKDYCTRFTND 192
             :....|:.:|..|:..||..||:.||..|.:|.::....     .|:|..|::.||.|.|||.|
  Fly   120 -LDGPEWRWLRQNLTQVFTSGKMKFMFPNMVEVGEKLTQA-----CRLQVGEIEAKDLCARFTTD 178

  Fly   193 VIASTAFGLQVNSFKDRENTFYQMGKKLTTFTFLQSMKFMLFFALKGLNKILKVELFDRKSTQYF 257
            ||.|.||||:.||.:|.|:.|.:||:.:|.......:.....||...|.:.|:..||..:.:::|
  Fly   179 VIGSCAFGLECNSLQDPESQFRRMGRSVTQEPLHSVLVQAFMFAQPELARKLRFRLFRPEVSEFF 243

  Fly   258 VRLVLDAMKYRQEHNIVRPDMINMLMEARGIIQTEKTKASAVREWSDRDIVAQCFVFFFAGFETS 322
            :..|...:.||:..||.|.|:|.:|||    :..|..|.:.    |...|.||..|||.|||:||
  Fly   244 LDTVRQTLDYRRRENIHRNDLIQLLME----LGEEGVKDAL----SFEQIAAQALVFFLAGFDTS 300

  Fly   323 AVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGKELTYEAIMGMKYLDQVVNEVLRKWPAAIAV 387
            :..|.|..:||..|.|||:||..||..| .....::|||:::..|.||||||.|.|||:|....:
  Fly   301 STTMSFCLYELALNPDVQERLRVEVLAV-LKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHL 364

  Fly   388 DRECNKDITFDVDGQKVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESIQPFTYFP 452
            .|...|:  :.:....:.::.|..|.:|....|.||:.:.:|.||||.||..|..::..||.|.|
  Fly   365 LRRSTKE--YQIPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAYLP 427

  Fly   453 FGLGQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSGFQLSPKGGFWIKL 512
            ||.|.|||||.||..|:.|..:.|||:|::|:.::|:.|||:..:..|.:|.:.|..:::
  Fly   428 FGEGPRNCIGERFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHLRM 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	171/474 (36%)
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	169/467 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461240
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800