DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9f2 and Cyp3a2

DIOPT Version :9

Sequence 1:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_695224.3	Gene:	Cyp3a2 / 266682	RGDID:	708379	Length:	504	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	171/524 - (32%)
Similarity:	280/524 - (53%)	Gaps:	46/524 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EFFALFAIAAALFYRWASANNDFFKDRGIAYEKPVLYFGNMAGMFLRKRAMFDIVCDLYTKGGSK 68
            |.:.|.|:...|.||..:..:..||.:||...||:.:.|.:.. :.:....||:.|  |.|.|
  Rat    10 ETWVLLAVILVLLYRLGTHRHGIFKKQGIPGPKPLPFLGTVLN-YYKGLGRFDMEC--YKKYG-- 69

  Fly    69 KFFGIFEQRQPLLMVRDPDLIKQITIKD-FDHFINHRNVFATSSDDDPHDMSNLFGSSLFSMRDA 132
            |.:|:|:.:.|:..:.|.::||.:.:|: |..|.|.|       |..|   ..:.|.::...:|.
  Rat    70 KIWGLFDGQTPVFAIMDTEMIKNVLVKECFSVFTNRR-------DFGP---VGIMGKAVSVAKDE 124

  Fly   133 RWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENELDMKDYCTRFTNDVIAST 197
            .||..|:.|||.||..::::||.::.|.....|..|||:..  ....:.||.....::.|||.||
  Rat   125 EWKRYRALLSPTFTSGRLKEMFPIIEQYGDILVKYLKQEAE--TGKPVTMKKVFGAYSMDVITST 187

  Fly   198 AFGLQVNSFKDRENTFYQMGKKLTTFTFLQS--MKFMLFFALKGLNKILKVELFDRKSTQYFVRL 260
            :||:.|:|..:.::.|.:..|||..|.|...  :..:||..|..:.::|.:.:|.:.|..:|.:.
  Rat   188 SFGVNVDSLNNPKDPFVEKTKKLLRFDFFDPLFLSVVLFPFLTPIYEMLNICMFPKDSIAFFQKF 252

  Fly   261 V-------LDAMKYRQEHNIVRPDMINMLMEARGIIQTEKTKASAVREWSDRDIVAQCFVFFFAG 318
            |       ||:   :.:|   |.|.:.:::.|....:.|.:.    :..||.:|:||..:|.|||
  Rat   253 VHRIKETRLDS---KHKH---RVDFLQLMLNAHNNSKDEVSH----KALSDVEIIAQSVIFIFAG 307

  Fly   319 FETSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGK-ELTYEAIMGMKYLDQVVNEVLRKWP 382
            :||::..:.|..:.|..:.|:|::|.||   :|..|..| ..||:.:|.|:|||.|:||.||.:|
  Rat   308 YETTSSTLSFVLYFLATHPDIQKKLQEE---IDGALPSKAPPTYDIVMEMEYLDMVLNETLRLYP 369

  Fly   383 AAIAVDRECNKDITFDVDGQKVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESIQP 447
            ....::|.|.|||  ::||  :.:.||.|:.:||...|.||:::..|.:|.|||||.|||.||.|
  Rat   370 IGNRLERVCKKDI--ELDG--LFIPKGSVVTIPTYALHHDPQHWPKPEEFHPERFSKENKGSIDP 430

  Fly   448 FTYFPFGLGQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSGFQLSPKGGFWIKL 512
            :.|.|||.|.|||||.||||:..|..:..:|:::.|.|.|::.|||:|..... |.|:....:|:
  Rat   431 YVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQAI-LEPEKPIVLKV 494

  Fly   513 VQRN 516
            :.|:
  Rat   495 LPRD 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	159/484 (33%)
Cyp3a2	NP_695224.3	CYP3A	67..493	CDD:410743	152/457 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H111391
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm9060
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.870