DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9f2 and Cyp3a23-3a1

DIOPT Version :9

Sequence 1:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_037237.2	Gene:	Cyp3a23-3a1 / 25642	RGDID:	628626	Length:	502	Species:	Rattus norvegicus

Alignment Length:	526	Identity:	173/526 - (32%)
Similarity:	285/526 - (54%)	Gaps:	52/526 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EFFALFAIAAALFYRWASANNDFFKDRGIAYEKPVLYFGNMAG--MFLRKRAMFDIVCDLYTKGG 66
            |.:.|.|:...|.|.:.:..:..||.:||...||:.:||.:..  |.|.|   ||:.|  :.|.|
  Rat    10 ETWVLLAVVLVLLYGFGTRTHGLFKKQGIPGPKPLPFFGTVLNYYMGLWK---FDVEC--HKKYG 69

  Fly    67 SKKFFGIFEQRQPLLMVRDPDLIKQITIKD-FDHFINHRNVFATSSDDDPHDMSNLFGSSLFSMR 130
              |.:|:|:.:.||..:.|.::||.:.:|: |..|.|.|       |..|   ..:.|.::...:
  Rat    70 --KIWGLFDGQMPLFAITDTEMIKNVLVKECFSVFTNRR-------DFGP---VGIMGKAISVSK 122

  Fly   131 DARWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENELDMKDYCTRFTNDVIA 195
            |..||..|:.|||.||..::::||.::.|.....|..|:|:..:    .:.:|:....::.|||.
  Rat   123 DEEWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQEKGK----PVPVKEVFGAYSMDVIT 183

  Fly   196 STAFGLQVNSFKDRENTFYQMGKKLTTFTFLQS--MKFMLFFALKGLNKILKVELFDRKSTQYFV 258
            ||:||:.|:|..:.::.|.:..|||....|...  :..:||..|..:.::|.:.:|.:.|.::|.
  Rat   184 STSFGVNVDSLNNPKDPFVEKAKKLLRIDFFDPLFLSVVLFPFLTPVYEMLNICMFPKDSIEFFK 248

  Fly   259 RLV-------LDAMKYRQEHNIVRPDMINMLMEARGIIQTEKTKASAVREWSDRDIVAQCFVFFF 316
            :.|       ||::   |:|   |.|.:.::|.|....:.:::..:.    ||.:|.||..:|.|
  Rat   249 KFVYRMKETRLDSV---QKH---RVDFLQLMMNAHNDSKDKESHTAL----SDMEITAQSIIFIF 303

  Fly   317 AGFETSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGK-ELTYEAIMGMKYLDQVVNEVLRK 380
            ||:|.::..:.|..|.|..:.|.|::|.||   :|:.|..| ..||:.:|.|:|||.|:||.||.
  Rat   304 AGYEPTSSTLSFVLHSLATHPDTQKKLQEE---IDRALPNKAPPTYDTVMEMEYLDMVLNETLRL 365

  Fly   381 WPAAIAVDRECNKDITFDVDGQKVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESI 445
            :|....::|.|.||:  :::|  |.:.||.|:.:|:...||||:::..|.:|.|||||.|||.||
  Rat   366 YPIGNRLERVCKKDV--EING--VFMPKGSVVMIPSYALHRDPQHWPEPEEFRPERFSKENKGSI 426

  Fly   446 QPFTYFPFGLGQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSGFQLSPKGGFWI 510
            .|:.|.|||.|.|||||.||||:..|..:..:|:::.|.|.|::.|||:|...|. |.|.....:
  Rat   427 DPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQGL-LQPTKPIIL 490

  Fly   511 KLVQRN 516
            |:|.|:
  Rat   491 KVVPRD 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	161/486 (33%)
Cyp3a23-3a1	NP_037237.2	p450	39..492	CDD:278495	161/491 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm9060
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.870