DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9f2 and Cyp3a9

DIOPT Version :9

Sequence 1:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_671739.2	Gene:	Cyp3a9 / 171352	RGDID:	708392	Length:	503	Species:	Rattus norvegicus

Alignment Length:	528	Identity:	175/528 - (33%)
Similarity:	282/528 - (53%)	Gaps:	55/528 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EFFALFAIAAALFYRWASANNDFFKDRGIAYEKPVLYFGNMAGMFLRKRAM-FDIVCDLYTKGGS 67
            |.:.|..|:..|.|.:.:.::..||..||...||:.:.|.:  :..||... ||..|  :.|.|
  Rat    10 ETWLLLVISLVLLYLYGTHSHGIFKKLGIPGPKPLPFLGTI--LAYRKGFWEFDKYC--HKKYG- 69

  Fly    68 KKFFGIFEQRQPLLMVRDPDLIKQITIKD-FDHFINHRNVFATSSDDDPHDMSNLFG------SS 125
             |.:|:::.|||:|.:.|||:||.:.:|: :..|.|.||                ||      .:
  Rat    70 -KLWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRN----------------FGPVGILKKA 117

  Fly   126 LFSMRDARWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENELDMKDYCTRFT 190
            :....|..||.:|:.|||.||..|:::||.::||.....|..::|...  :.....|||....::
  Rat   118 ISISEDEEWKRIRALLSPTFTSGKLKEMFPIINQYTDMLVRNMRQGSE--EGKPTSMKDIFGAYS 180

  Fly   191 NDVIASTAFGLQVNSFKDRENTFYQMGKKLTTFTFLQS--MKFMLFFALKGLNKILKVELFDRKS 253
            .|||.:|:||:.|:|..:.::.|.:..|||..|.....  :...||..|..|.:.|.|.:|.|..
  Rat   181 MDVITATSFGVNVDSLNNPQDPFVEKIKKLLKFDIFDPLFLSVTLFPFLTPLFEALNVSMFPRDV 245

  Fly   254 TQYF----VRLVLDAMKYRQEHNIVRPDMINMLMEARGIIQTEKTKASAVREWSDRDIVAQCFVF 314
            ..:|    .|:..:.||.:::.   |.|.:.:::.:    |..|.|.|. :..||.:||||..:|
  Rat   246 IDFFKTSVERMKENRMKEKEKQ---RMDFLQLMINS----QNSKVKDSH-KALSDVEIVAQSVIF 302

  Fly   315 FFAGFETSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGK-ELTYEAIMGMKYLDQVVNEVL 378
            .|||:||::..:.|..:.|..:.|:|::|.:|   :|..|..| ..||:.::.|:|||.||||.|
  Rat   303 IFAGYETTSSALSFVLYLLAIHPDIQKKLQDE---IDAALPNKAHATYDTLLQMEYLDMVVNETL 364

  Fly   379 RKWPAAIAVDRECNKDITFDVDGQKVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKE 443
            |.:|.|..::|.|..|:  :::|  |.:.||.|:.:||...|:||.|:..|.:|.|||||.:|::
  Rat   365 RLYPIAGRLERVCKTDV--EING--VFIPKGTVVMIPTFALHKDPHYWPEPEEFRPERFSKKNQD 425

  Fly   444 SIQPFTYFPFGLGQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSGFQLSPKGGF 508
            :|.|:.|.|||.|.|||||.||||:..|..:..:|:::.|.|.|::.|||:|...|. |.|:...
  Rat   426 NINPYMYLPFGNGPRNCIGMRFALMNMKVALVRVLQNFSFQPCKETQIPLKLSKQGL-LQPEKPL 489

  Fly   509 WIKLVQRN 516
            .:|:|.|:
  Rat   490 LLKVVSRD 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	163/488 (33%)
Cyp3a9	NP_671739.2	p450	39..493	CDD:278495	163/493 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm9060
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.770