DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9f2 and CYP3A5

DIOPT Version :9

Sequence 1:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens

Alignment Length:	527	Identity:	180/527 - (34%)
Similarity:	289/527 - (54%)	Gaps:	54/527 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EFFALFAIAAALFYRWASANNDFFKDRGIAYEKPVLYFGNM----AGMFLRKRAMFDIVCDLYTK 64
            |.:.|.|::..|.|.:.:..:..||..||....|:...||:    .|::     .||..|  |.|
Human    10 ETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLW-----KFDTEC--YKK 67

  Fly    65 GGSKKFFGIFEQRQPLLMVRDPDLIKQITIKD-FDHFINHRNVFATSSDDDPHDMSNLFGSSLFS 128
            .|  |.:|.:|.:.|:|.:.|||:|:.:.:|: :..|.|.|::....           |..|..|
Human    68 YG--KMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVG-----------FMKSAIS 119

  Fly   129 M-RDARWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENELDMKDYCTRFTND 192
            : .|..||.:||.|||.||..|:::||.::.|.....|..|:::..:  ...:.:||....::.|
Human   120 LAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEK--GKPVTLKDIFGAYSMD 182

  Fly   193 VIASTAFGLQVNSFKDRENTFYQMGKKLTTFTFLQS--MKFMLFFALKGLNKILKVELFDRKSTQ 255
            ||..|:||:.::|..:.::.|.:..||...|.||..  :..:||..|..:.:.|.|.||. |.|.
Human   183 VITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFP-KDTI 246

  Fly   256 YFVRLVLDAMKY-----RQEHNIVRPDMINMLMEARGIIQTEKTKASAVREWSDRDIVAQCFVFF 315
            .|:...::.||.     :|:|   |.|.:.::::::...:||..||     .||.::.||..:|.
Human   247 NFLSKSVNRMKKSRLNDKQKH---RLDFLQLMIDSQNSKETESHKA-----LSDLELAAQSIIFI 303

  Fly   316 FAGFETSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGK-ELTYEAIMGMKYLDQVVNEVLR 379
            |||:||::.::.||.:||..:.||||:|.:|:..|   |..| ..||:|::.|:|||.||||.||
Human   304 FAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAV---LPNKAPPTYDAVVQMEYLDMVVNETLR 365

  Fly   380 KWPAAIAVDRECNKDITFDVDGQKVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKES 444
            .:|.||.::|.|.||:  :::|  |.:.||.::.:||...|.||||:..|.:|.||||| :.|:|
Human   366 LFPVAIRLERTCKKDV--EING--VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-KKKDS 425

  Fly   445 IQPFTYFPFGLGQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSGFQLSPKGGFW 509
            |.|:.|.|||.|.|||||.||||:..|..:..:|:::.|.|.|::.|||:|.|.|. |.|:....
Human   426 IDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGL-LQPEKPIV 489

  Fly   510 IKLVQRN 516
            :|:..|:
Human   490 LKVDSRD 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	169/487 (35%)
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	169/492 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1946
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2940
Isobase	1	0.950	-	0	Normalized mean entropy	S3417
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8623
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.720