DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9f2 and CYP3A7-CYP3A51P

DIOPT Version :9

Sequence 1:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001243426.2	Gene:	CYP3A7-CYP3A51P / 100861540	HGNCID:	51504	Length:	535	Species:	Homo sapiens

Alignment Length:	514	Identity:	170/514 - (33%)
Similarity:	281/514 - (54%)	Gaps:	48/514 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EFFALFAIAAALFYRWASANNDFFKDRGIAYEKPVLYFGNMAGMFLRKRAMFDIVCDLYTKGGSK 68
            |.:.|.|::..|.|.:.:..:..||..||....|:.:.|| |..|.:....||:.|  |.|  .:
Human    10 ETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGN-ALSFRKGYWTFDMEC--YKK--YR 69

  Fly    69 KFFGIFEQRQPLLMVRDPDLIKQITIKD-FDHFINHRNVFATSSDDDPHDMSNLFGSSLFSMRDA 132
            |.:||::.:||:|.:.|||:||.:.:|: :..|.|.|          |........:::....|.
Human    70 KVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRR----------PFGPVGFMKNAISIAEDE 124

  Fly   133 RWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQE--NELDMKDYCTRFTNDVIA 195
            .||.:||.|||.||..|:::|..::.|..    |.|.::..|..|  ..:.:|.....::.|||.
Human   125 EWKRIRSLLSPTFTSGKLKEMVPIIAQYG----DVLVRNLRREAETGKPVTLKHVFGAYSMDVIT 185

  Fly   196 STAFGLQVNSFKDRENTFYQMGKKLTTFT----FLQSMKFMLFFALKGLNKILKVELFDRKSTQY 256
            ||:||:.::|..:.::.|.:..|||..|.    |:.|:|...|  |..:.:.|.:.:|.||...:
Human   186 STSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPF--LTPILEALNITVFPRKVISF 248

  Fly   257 FVRLVLD----AMKYRQEHNIVRPDMINMLMEARGIIQTEKTKASAVREWSDRDIVAQCFVFFFA 317
            ..:.|..    .:|..|:|   |.|.:.::::::....:|..||     .||.:::||..:|.||
Human   249 LTKSVKQIKEGRLKETQKH---RVDFLQLMIDSQNSKDSETHKA-----LSDLELMAQSIIFIFA 305

  Fly   318 GFETSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGK-ELTYEAIMGMKYLDQVVNEVLRKW 381
            |:||::.::.|..:||..:.||||::.:|:..|   |..| ..||:.::.::|||.||||.||.:
Human   306 GYETTSSVLSFIIYELATHPDVQQKVQKEIDTV---LPNKAPPTYDTVLQLEYLDMVVNETLRLF 367

  Fly   382 PAAIAVDRECNKDITFDVDGQKVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESIQ 446
            |.|:.::|.|.||:  :::|  :.:.||.|:.:|:...|.||||:..|.||.|||||.:||::|.
Human   368 PVAMRLERVCKKDV--EING--MFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNID 428

  Fly   447 PFTYFPFGLGQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSGFQLSPK 505
            |:.|.|||.|.|||||.||||:..|..:..:|:::.|.|.|::.|||:|...|..|:.|
Human   429 PYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEK 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	161/482 (33%)
CYP3A7-CYP3A51P	NP_001243426.2	p450	39..492	CDD:278495	161/485 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1946
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2940
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8623
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.770