DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9f2 and Cyp3a59

DIOPT Version :9

Sequence 1:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001098630.1	Gene:	Cyp3a59 / 100041449	MGIID:	3769707	Length:	503	Species:	Mus musculus

Alignment Length:	523	Identity:	164/523 - (31%)
Similarity:	275/523 - (52%)	Gaps:	45/523 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EFFALFAIAAALFYRWASANNDFFKDRGIAYEKPVLYFGNMAGMFLRKRAMFDIVCDLYTKGGSK 68
            |.:.|...:...||.:.:.::..||..||...||:..||.:...|   ..|:....|.|.|.|
Mouse    10 ETWVLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFGTIFNYF---DGMWKFDEDCYKKYG-- 69

  Fly    69 KFFGIFEQRQPLLMVRDPDLIKQITIKD-FDHFINHRNVFATSSDDDPHDMSNLFGSSLFSMRDA 132
            |.:|.:...:|:|.:.||::||.:.:|: :..|.|...:...          .....|:....|.
Mouse    70 KIWGFYVGPKPILAIMDPEIIKIVLVKECYSVFTNRPTLGPV----------GFLKKSITISEDE 124

  Fly   133 RWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENELDMKDYCTRFTNDVIAST 197
            .||.:|:.|||.||..|:::||.:|.|.....|..|::::.:.:  .::|||....::.|||..|
Mouse   125 EWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGE--PINMKDIFGAYSMDVITGT 187

  Fly   198 AFGLQVNSFKDRENTFYQMGKKLTTF----TFLQSMKFMLFFALKGLNKILKVELFDRKSTQYFV 258
            :||:.::|..:.:|.|.|..||:..|    .||.|.  :||..|..:.::|.:.:|.|.|..:|.
Mouse   188 SFGVNIDSLNNPQNPFVQKTKKILKFKIFDPFLLST--ILFPFLTPIYEMLNLSIFPRDSMNFFK 250

  Fly   259 RLVLDAMKYR---QEHNIVRPDMINMLMEARGIIQTEKTKASAVREWSDRDIVAQCFVFFFAGFE 320
            :.|....|.|   ::.|  |.|.:.::|..:.....|..||     .||.::.||..:|.|.|::
Mouse   251 KFVKRMKKERLASKQKN--RVDFLQLMMNTQNSKGQESQKA-----LSDLEMAAQAVIFIFGGYD 308

  Fly   321 TSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGK-ELTYEAIMGMKYLDQVVNEVLRKWPAA 384
            .::..:....:||..:.|||::|.:|   :|:.|..| .:||:|:|.|:|||.||||.||.:|.|
Mouse   309 ATSTSISLIMYELATHPDVQKKLQDE---IDRTLPNKAPVTYDALMDMEYLDMVVNESLRLYPTA 370

  Fly   385 IAVDRECNKDITFDVDGQKVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESIQPFT 449
            |.::|...||:  :::|  |.:.||.|:.:|....||:|:|:..|.:|.|.|||.||:.:|.|:.
Mouse   371 IRLERVSKKDV--EING--VFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPGRFSKENEGNIDPYI 431

  Fly   450 YFPFGLGQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSG-FQLSPKGGFWIKLV 513
            |.|||.|.|||:..||||:..|..:..:|:::...|.:::.|||::.... ||  |:....:|:|
Mouse   432 YMPFGNGPRNCLDMRFALISMKLAVIGVLQNFTVQPCEETQIPLKISREPVFQ--PEKPIILKVV 494

  Fly   514 QRN 516
            .|:
Mouse   495 SRD 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	153/483 (32%)
Cyp3a59	NP_001098630.1	p450	39..493	CDD:278495	153/488 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2821
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.770