Protein Alignment DNAlig3 and DNL4

DIOPT Version :9

• Sequence 1: NP_650187.2
• Gene: DNAlig3 / 41518
• FlyBaseID: FBgn0286075
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: NP_014647.1
• Gene: DNL4 / 854166
• SGDID: S000005531
• Length: 944
• Species: Saccharomyces cerevisiae
• Alignment Length: 914
• Identity: 191/914 - (20%)
• Similarity: 323/914 - (35%)
• Gaps: 325/914 - (35%)

  Fly    36 FRRICDEI--------------AGESSYLKKAERLQRFFE--KGSSGKGFKGDTVLWVQFLIPAA 84
            |:.:|:|:              .|:|...|..|.:..|.|  :.:.|.......||    .:|..
Yeast    20 FKWLCEELFVKIHEVQINGTAGTGKSRSFKYYEIISNFVEMWRKTVGNNIYPALVL----ALPYR 80

  Fly    85 NQRVYNLQNKALIKLFSRIF----NADQQQMHLDLEQ----DGDVSETLRK-------------- 127
            ::|:||:::..||:......    |:..:|...|.:|    .|::|..|.:
Yeast    81 DRRIYNIKDYVLIRTICSYLKLPKNSATEQRLKDWKQRVGKGGNLSSLLVEEIAKRRAEPSSKAI 145

  Fly   128 ---------------HFAASKKLKPQKQSKLYLQEVEEMLLHLVERTKEDEQTDLLQKLCSKATD 177
                           .||:.:..|...:||.:|..||.|                        :.
Yeast   146 TIDNVNHYLDSLSGDRFASGRGFKSLVKSKPFLHCVENM------------------------SF 186

  Fly   178 LDLRTFIRLVKHDLRINARARHILDAFGPDAYPAYQSSRDLVAIVEQFATKENKNYASSPVKKTK 242
            ::|:.|..:|..:..|..:...:|:.:.|||       :|.::::.......:|.|  .| |...
Yeast   187 VELKYFFDIVLKNRVIGGQEHKLLNCWHPDA-------QDYLSVISDLKVVTSKLY--DP-KVRL 241

  Fly   243 KTSSSAIQVMTPISPMLASP--------CKSVEDAFKKSPTGLYSEIKYDGERVQIH--KQGNDF 297
            |....:|:|....:|.||..        |:::.|.|       ..|.|.||||:|:|  ..|...
Yeast   242 KDDDLSIKVGFAFAPQLAKKVNLSYEKICRTLHDDF-------LVEEKMDGERIQVHYMNYGESI 299

  Fly   298 KFFSRNLKPVVDHKIRALKKYIPQAFPGGG-------------EMILDSEIILVDTDTGALLPFG 349
            |||||.   .:|:      .|:..|....|             |.:||.|::..|.....:||||
Yeast   300 KFFSRR---GIDY------TYLYGASLSSGTISQHLRFTDSVKECVLDGEMVTFDAKRRVILPFG 355

  Fly   350 SLGAHKKQTFANAAV-------CLFVFDCILYDGEDLTQLPFRKRREILEQNIQPIKSHVQLSES 407
            .:....|:..:..::       ...|||.:..:|..||.||..:|::.|...:.|:|:.|::..|
Yeast   356 LVKGSAKEALSFNSINNVDFHPLYMVFDLLYLNGTSLTPLPLHQRKQYLNSILSPLKNIVEIVRS 420

  Fly   408 ------EFLKTTRELAAMTARVLHANLEGVVLKSPTSTYQPGKR--NWLKVKKDYLFDGKMADTA 464
                  |.:|.:.|:|      :....||||||...|:|....|  ||:|||.:||  .:..:..
Yeast   421 SRCYGVESIKKSLEVA------ISLGSEGVVLKYYNSSYNVASRNNNWIKVKPEYL--EEFGENL 477

  Fly   465 DLVVLGAWYGSGKKGGTLSIFLMGCYDAFGRLWKTVTKVHSG----LDDATNAEVH--------- 516
            ||:|:|.  .||||..    |::|..    .|.:...|.|.|    :.|.::.|.|
Yeast   478 DLIVIGR--DSGKKDS----FMLGLL----VLDEEEYKKHQGDSSEIVDHSSQEKHIQNSRRRVK 532

  Fly   517 -----------------KSLIKLT----ERADANAIPSWLLCSKSLVPDVLAK--DPMKMPVWEI 558
                             |.:.:.|    :|....|.|:.:|...|.:|   |:  ||.:..|.||
Yeast   533 KILSFCSIANGISQEEFKEIDRKTRGHWKRTSEVAPPASILEFGSKIP---AEWIDPSESIVLEI 594

  Fly   559 TGAEFTKSDAHT---ASGISVRFPRITRRRSDKSAKEANDLAHLEDLFEASKSNVNVDLLLANCS 620
            .......::.:.   |:..::......|.|.|   ||..|...|.||:|
Yeast   595 KSRSLDNTETNMQKYATNCTLYGGYCKRIRYD---KEWTDCYTLNDLYE---------------- 640

  Fly   621 KDETAMNNKTTPEKEKKLNGNQSNGSKKLKRSNTGSDDEDGAPVLSKRKESKAIRSLSPSQKGLK 685
                   ::|.          :||.|.:.:||..|         |.::|..:.:         :.
Yeast   641 -------SRTV----------KSNPSYQAERSQLG---------LIRKKRKRVL---------IS 670

  Fly   686 DFFKPSKEFKSVVKKEPKEDEGNIESTSSKPQLFEGLVAHFAME---KDS------SKLMQQFSQ 741
            |.|..::      |:.|..:            :|.||:.:...:   :|:      ::|.:...:
Yeast   671 DSFHQNR------KQLPISN------------IFAGLLFYVLSDYVTEDTGIRITRAELEKTIVE 717

  Fly   742 HGG--------------------CCTTEPQKADLVFYANTNEALDLEKLRTLYRRSCRHLNVSWL 786
            |||                    |.||...||                   |..|....|:.:|:
Yeast   718 HGGKLIYNVILKRHSIGDVRLISCKTTTECKA-------------------LIDRGYDILHPNWV 763

  Fly   787 QSCL 790
            ..|:
Yeast   764 LDCI 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig3	NP_650187.2	DNA_ligase_A_N	36..200	CDD:282522	38/216 (18%)
		dnl1	88..604	CDD:273147	145/629 (23%)
		Adenylation_DNA_ligase_III	242..454	CDD:185712	69/249 (28%)
		OBF_DNA_ligase_III	460..598	CDD:153436	38/176 (22%)
DNL4	NP_014647.1	DNA_ligase_A_N	20..207	CDD:282522	38/214 (18%)
		dnl1	84..717	CDD:273147	164/775 (21%)
		Adenylation_DNA_ligase_IV	244..471	CDD:185713	70/250 (28%)
		OBF_DNA_ligase_IV	474..635	CDD:153437	38/176 (22%)
		BRCT	681..767	CDD:278934	18/116 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810