DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNAlig3 and AT1G49250

DIOPT Version :9

Sequence 1:	NP_650187.2	Gene:	DNAlig3 / 41518	FlyBaseID:	FBgn0286075	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_175351.1	Gene:	AT1G49250 / 841349	AraportID:	AT1G49250	Length:	657	Species:	Arabidopsis thaliana

Alignment Length:	674	Identity:	167/674 - (24%)
Similarity:	282/674 - (41%)	Gaps:	143/674 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLSRLTWQARI-LTRLLCNKMASKGLHNEDNKLDTFRRICDEIAGESSYLKKAERLQRFFEKGS 64
            :|..:.|...|| :|.:|||.:.:......|:.|.|.....:|||.....:|.           .
plant    51 LLKKKPTESGRIVITHILCNMLRTVIATTPDDLLPTVYLAANEIAPAHEGIKL-----------G 104

  Fly    65 SGKGFKGDTVLWVQFLIPAANQRVYNLQNKALIKLFSRIFNADQQQMHLDLEQDGDVSETLRKHF 129
            .|||                         ..:||..|..|...:..:.....|.||:.  |..:.
plant   105 MGKG-------------------------SYIIKAISEAFGRTESHVEQQYTQLGDLG--LVANG 142

  Fly   130 AASKKLKPQKQSKLYLQEVEEMLLHLVERT---KEDEQTDLLQKLCSKATDLDLRTFIRLVKHDL 191
            :.|.:........|.:.:|.:.|..:.:.:   .:|::.||::.|....||.:.....||::.:|
plant   143 SRSSQTMIFMPKPLTVVKVADTLRLIAKESGKGSKDKKKDLMKALLVATTDCEPLYLTRLLQDNL 207

  Fly   192 RINARARHILDAFGPDAYPAYQSSR---DLVAIVEQFATKENKNYASSPVK-------------K 240
            |:....:.:|.|.|..|....:.|:   ::...:::.||...:.::..||.             .
plant   208 RLGFSRQTVLAALGQAAVYNEEHSKPPPNIKNPLDEAATIVKEVFSMLPVYDIIVGALLTSGVWN 272

  Fly   241 TKKTSSSAIQVMTPISPMLASPCKSVEDAFKK-SPTGLYSEIKYDGERVQI-HKQGNDFKFFSRN 303
            ..||.:..:.|  |:.||||.....|:...:| ..|...:|.||||||.|| :.:....:.|||:
plant   273 LPKTCNLTLGV--PVRPMLAKATTRVDLILEKFKDTVFTAEYKYDGERAQIYYMEDGTVEIFSRH 335

  Fly   304 LK------PVVDHKIRALKKYIPQAFPGGGEMILDSEIILVDTDTGALLPFGSLGAHKKQTFAN- 361
            .:      |.|...:..|||...::|      |||.|::..:.:...:||..|..|||....::
plant   336 AERNTGKYPDVALVLSRLKKPTVKSF------ILDCEVVTFNREKEKILPLQSTRAHKNVNVSDI 394

  Fly   362 -AAVCLFVFDCILYDGEDLTQLPFRKRREILEQNIQPIKSHVQLSES----------EFLKTTRE 415
             ..||:|.||.:..:|:.|.......|||.|..:.:....:.|.:.:          ||||.:.:
plant   395 KVGVCVFAFDILYLNGQLLIHENLNIRREKLHDSFEEDLGYFQFATALTSNDIGELQEFLKASID 459

  Fly   416 LAAMTARVLHANLEGVVLKS--PTSTYQPGKR--NWLKVKKDYLFDGKMADTADLVVLGAWYGSG 476
            :..          ||:::||  ..:||:|.||  ||||:||||:  ..:.|:.|||.:..::|.|
plant   460 IGC----------EGLMIKSLYSNATYEPAKRSNNWLKLKKDYM--DNIGDSVDLVPIATFHGRG 512

  Fly   477 KKGGTLSIFLMGCYDAFGRLWKTVTKVHSGLDDATNAEVHKSLIKLTERADANAIPSWLLCSK-- 539
            |:.|....:|:.|||.....::::.|:.:...|....::..|                 ||||
plant   513 KRTGFFGAYLLACYDVDKEEFQSICKIGTEFSDVELQDLSSS-----------------LCSKVI 560

  Fly   540 -----------SLVPDVLAKDPMKMPVWEITGAEFTKSDAHTAS--------GISVRFPRITRRR 585
                       .|.|||.. :|.:  |||:..|:.|.|..:..:        |||:||||:.|.|
plant   561 ATPKQYYQVDNDLNPDVWL-EPTE--VWEVKAADLTVSPVYREAIGIVDPDKGISLRFPRLVRIR 622

  Fly   586 SDKSAKEANDLAHLEDLFEASKSN 609
            .||:.:||.....:.::::|.|.|
plant   623 KDKNPEEATTSDQIAEMYQAQKHN 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig3	NP_650187.2	DNA_ligase_A_N	36..200	CDD:282522	29/166 (17%)
		dnl1	88..604	CDD:273147	146/579 (25%)
		Adenylation_DNA_ligase_III	242..454	CDD:185712	70/235 (30%)
		OBF_DNA_ligase_III	460..598	CDD:153436	43/158 (27%)
AT1G49250	NP_175351.1	PLN03113	2..657	CDD:215584	167/674 (25%)
		DNA_ligase_A_N	57..216	CDD:282522	39/196 (20%)
		Adenylation_DNA_ligase_I_Euk	276..492	CDD:185710	69/233 (30%)
		OBF_DNA_ligase_I	497..642	CDD:153438	43/164 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274264at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820