DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig3 and Lig1

DIOPT Version :9

Sequence 1:	NP_650187.2	Gene:	DNAlig3 / 41518	FlyBaseID:	FBgn0286075	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	XP_038947878.1	Gene:	Lig1 / 81513	RGDID:	621424	Length:	928	Species:	Rattus norvegicus

Alignment Length:	670	Identity:	162/670 - (24%)
Similarity:	252/670 - (37%)	Gaps:	202/670 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 FRRICD--EIAGESSYLKKAERLQ-----------RFFEKGSSGKGFKGDTVLWVQFLIPAANQR 87
            |.:.||  .:.|.:|..||.:.::           ||..:..||:...|   |..|.::.|..|.
  Rat   415 FTKFCDIARLTGSASMAKKMDIIKGLFVACRYSEARFIARSLSGRLRLG---LAEQSVLAALAQA 476

  Fly    88 VYNLQNKALIKLFSRIFNADQQQMHLDLEQDGDVSETLRKHFAASKKLKPQKQSKLYLQEVEEML 152
            |                         .|...|....|.   ...:.|.|..:..|::|
  Rat   477 V-------------------------SLTPPGQEFPTA---VVDAGKGKTAEARKMWL------- 506

  Fly   153 LHLVERTKEDEQTDLLQKLCSKATDLDLRTFIRLVKHDLRINARARHILDAFGPDAYPAYQSSRD 217
                     :||..:|::...:..||| |....|::|               |.::.|.:
  Rat   507 ---------EEQGMILKQTFCEVPDLD-RIIPVLLEH---------------GLESLPEH----- 541

  Fly   218 LVAIVEQFATKENKNYASSPVKKTKKTSSSAIQVMTPISPMLASPCKSVEDAFKK-SPTGLYSEI 281
                                         ..:....|:.||||.|.:.|.:..|: .......|.
  Rat   542 -----------------------------CKLSPGVPLKPMLAHPTRGVREVLKRFEEVDFTCEY 577

  Fly   282 KYDGERVQIH-KQGNDFKFFSRNLK------PVVDHKIRALKKYIPQAFPGGGEMILDSEIILVD 339
            ||||:|.||| .:|.:.|.||||.:      |.:..:|..:|      .|.....|||:|.:..|
  Rat   578 KYDGQRAQIHVLEGGEVKIFSRNQEDNSGKYPDIISRIPKIK------HPSVTSFILDTEAVAWD 636

  Fly   340 TDTGALLPFGSLGAHKKQ----TFANAAVCLFVFDCILYDGEDLTQLPFRKRREILEQNIQPIKS 400
            .:...:.||..|...|::    :.....|||:.||.|..:||.|.:.|..:||::|.:|....:.
  Rat   637 REKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLARQPLSRRRQLLRENFVETEG 701

  Fly   401 HVQLSESEFLKTTRELAAMTARVLHANLEGVVLKS--PTSTYQPGKR--NWLKVKKDYLFDGKMA 461
            ....:.|...|...::|....:.:..:.||:::|:  ..:||:..||  ||||:||||| :| :.
  Rat   702 EFVFATSLDTKDIEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYL-EG-VG 764

  Fly   462 DTADLVVLGAWYGSGKKGGTLSIFLMGCYDAFGRLWKTVTKVHSGLDDATNAEVHKSLIKLT--- 523
            ||.||||:||:.|.||:.|....||:..||......:.:.|:.:|..|....|.|:|:..|.
  Rat   765 DTLDLVVIGAYLGRGKRAGRYGGFLLAAYDEESEELQAICKLGTGFSDEELEEHHQSMQALLLPT 829

  Fly   524 ----ERADANAIPS-WLLCSKSLVPDVLAKDPMKMPVWEITGAEFTKSDAHTAS--------GIS 575
                .|.|....|. ||             ||  ..|||:..|:.:.|..:.|:        |||
  Rat   830 PRPYVRIDGAVAPDHWL-------------DP--SVVWEVKCADLSLSPIYPAARGLVDKEKGIS 879

  Fly   576 VRFPRITRRRSDKSAKEANDLAHLEDLFEASKSNVNVDLLLANCSKDETAMNNKTTPEKEKKLNG 640
            :||||..|.|.||..::|.....:..|:                             .|:.::..
  Rat   880 LRFPRFIRVREDKQPEQATTSDQVASLY-----------------------------RKQSQIQN 915

  Fly   641 NQSNGSKKLKRSNTGSDDED 660
            .||        |:..||.||
  Rat   916 QQS--------SDLDSDVED 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig3	NP_650187.2	DNA_ligase_A_N	36..200	CDD:282522	33/176 (19%)
		dnl1	88..604	CDD:273147	138/547 (25%)
		Adenylation_DNA_ligase_III	242..454	CDD:185712	66/227 (29%)
		OBF_DNA_ligase_III	460..598	CDD:153436	48/153 (31%)
Lig1	XP_038947878.1	PTZ00121	<2..270	CDD:173412
Lig1	XP_038947878.1	PLN03113	174..924	CDD:215584	158/665 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274264at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820