DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig3 and lig4

DIOPT Version :9

Sequence 1:	NP_650187.2	Gene:	DNAlig3 / 41518	FlyBaseID:	FBgn0286075	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001096593.1	Gene:	lig4 / 569525	ZFINID:	ZDB-GENE-070820-10	Length:	909	Species:	Danio rerio

Alignment Length:	776	Identity:	189/776 - (24%)
Similarity:	330/776 - (42%)	Gaps:	145/776 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 VQFLIPA--ANQRVYNLQNKALIKLFSRIF----NADQQQMHLDLE----QDGDVSE-TLRKHFA 130
            ::.::|:  ..:..|.::...|.||:..:.    |.|:....|:..    ..|:..: .|..:|.
Zfish    73 MRLIVPSFERERMAYGIKENMLAKLYIEVLGLPKNGDEANKLLNYRAPTTSQGEAGDFALMAYFV 137

  Fly   131 ASKKLKPQKQSKLYLQEVEEMLLHLVERTKEDEQTDLLQK----LCSKATDLDLRTFIRLVKHDL 191
            ..|:.  ..|..|.::||.: .|..|......:|.|.::|    |.::::.|:.:..||::..|:
Zfish   138 LKKRC--TSQGNLSIKEVND-FLGSVATNNASKQKDQVKKSLLHLITQSSALEQKWLIRMILKDM 199

  Fly   192 RINARARHILDAFGPDAYPAYQSSRDLVAIVEQFATKENKNYASSPVKKTKKTSSSAIQVMTPIS 256
            ::......:|..|.|||...|..:.||..:..|.         ..|   :...|..:|.:.:...
Zfish   200 KLGISKETVLQVFHPDAPEFYNVTTDLNKVCRQL---------HDP---SVSLSEVSIDLFSAFK 252

  Fly   257 PMLASPC--KSVEDAFKKSPTGLYSEIKYDGERVQIHKQGNDFKFFSRN---------LKPVVDH 310
            ||||:..  :.:|......|  .|.|.|.||||:|:||.|:.:|:::||         ..|:..
Zfish   253 PMLAAVANIRQIEKQMGNRP--FYIETKLDGERIQLHKAGDVYKYYTRNSYEYTQQFGASPLEG- 314

  Fly   311 KIRALKKYIPQAF-PGGGEMILDSEIILVDTDTGALLPFGSLGAHKKQT-FANAAVCLFVFDCIL 373
               :|..||...| |.....|||.|::..:..|...:..||....|:.. .::...|..|||.:|
Zfish   315 ---SLTPYIHTVFSPHVVNCILDGEMMAYNPKTETFMQKGSKFDIKRLVDDSDLQTCFCVFDVLL 376

  Fly   374 YDGEDLTQLPFRKRREILEQNIQPIKSHVQLSESEFLKTTRELAAMTARVLHANLEGVVLKSPTS 438
            .:.:...:.|.:||.|.||....|||..:.|......:|.:|:.......:....||:::|.|.|
Zfish   377 INNQKFGKEPLKKRYESLETVFSPIKGRIHLVSKSEGRTMQEVVNSLNEAIDNREEGIMVKDPMS 441

  Fly   439 TYQPGKR--NWLKVKKDYLFDGKMADTADLVVLGAWYGSGKKGGTLSIFLMGCYDAFG-----RL 496
            .|:|.||  .|||:|.:|: ||.| |..||:::|.::|.|::.|.||.||....:...     .:
Zfish   442 IYKPDKRGEGWLKIKPEYV-DGLM-DELDLLIVGGYWGKGRRSGMLSHFLCAVAEVPSPGEKPTV 504

  Fly   497 WKTVTKVHSGLDDATNAEVHKSLIKLTER---ADANAIPSWLLCSKSLVPDVLAKDPMKMPVWEI 558
            :.|:.::.||.   |..|::...:||.:.   .:.|..|:.:||... .|:|.. :|....:.::
Zfish   505 FHTLCRIGSGY---TLKELYDLGVKLAKHWKVYNKNNPPAAILCGTE-KPEVYI-EPRNSVILQV 564

  Fly   559 TGAEFTKSDAHTASGISVRFPRITRRRSDKSAKEANDLAHLEDLFE-ASKSNVNVDLLLANCSKD 622
            ..||...|:.: .:..::|||||.|.|.|   ||.:....|:||.: .||::..:.....|..:|
Zfish   565 KAAEIVTSEMY-KTDCTLRFPRIERIRED---KEWHQCMTLDDLNQFRSKASGKLASRHLNIHED 625

  Fly   623 ETAMNNKTTPEKEKKLNGNQSNGSKKLKRSNTGSDDEDGAPVLSKRKESKAIRSLSPSQKGLKDF 687
            :        |||:|:                         .:::|.|  |.|        |:.|.
Zfish   626 Q--------PEKKKR-------------------------KIVAKPK--KTI--------GVIDH 647

  Fly   688 FKPSKEFKSVVKKEPKEDEG-----NIESTSSKPQLFEGLVAHFAMEKDSSKLMQQFSQHGGCCT 747
            || |::...|.|:....:|.     |.:...||.:|.:|:                 ::.||...
Zfish   648 FK-SQDLSKVAKETDMFEEVEFCVINGDDEHSKAELEKGV-----------------ARCGGIVV 694

  Fly   748 TEPQKADLVFYANTNEALDLEKLRTLYRRSCRH--LNVSWLQSCLDTQSRQPF-PLHAVMM 805
            ..|.|......|    |:...:::.|. .|.:|  :..:||..||:.:...|: |.|.:.|
Zfish   695 QNPGKDTYCAIA----AVQNMRVKNLI-SSDQHDVVWATWLLECLENKQVIPWQPRHMIHM 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig3	NP_650187.2	DNA_ligase_A_N	36..200	CDD:282522	26/137 (19%)
		dnl1	88..604	CDD:273147	146/551 (26%)
		Adenylation_DNA_ligase_III	242..454	CDD:185712	66/226 (29%)
		OBF_DNA_ligase_III	460..598	CDD:153436	39/145 (27%)
lig4	NP_001096593.1	DNA_ligase_A_N	20..208	CDD:282522	26/137 (19%)
		dnl1	86..606	CDD:273147	146/551 (26%)
		Adenylation_DNA_ligase_IV	240..461	CDD:185713	67/227 (30%)
		OBF_DNA_ligase_IV	464..601	CDD:153437	39/146 (27%)
		DNA_ligase_IV	754..786	CDD:288294
		BRCT	<845..896	CDD:278934
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D189866at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820