DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig3 and lig3

DIOPT Version :9

Sequence 1:	NP_650187.2	Gene:	DNAlig3 / 41518	FlyBaseID:	FBgn0286075	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001025345.2	Gene:	lig3 / 563276	ZFINID:	ZDB-GENE-030131-8453	Length:	1011	Species:	Danio rerio

Alignment Length:	817	Identity:	339/817 - (41%)
Similarity:	470/817 - (57%)	Gaps:	77/817 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QARILTRLLCNKMASKGLHNEDNKLDTFRRICDEIAGESSYLKKAERLQRFFEKGSSGKGFKGDT 73
            |..:|:..:|:..      ::||.|..||::|..:|.:|.|..|.|.::.|..|||.|..|:||.
Zfish   244 QGSVLSAQMCDPT------HKDNLLREFRKLCALVAEKSGYNAKTEIVRDFLTKGSGGDKFRGDL 302

  Fly    74 VLWVQFLIPAANQRVYNLQNKALIKLFSRIFNADQQQMHLDLEQDGDVSETLRKHFAASKKLKPQ 138
            .|.|:.|:|...:.||||.:|.::||||||.|.:|..|..|||| ||||||:|..|..||...|.
Zfish   303 YLTVKLLLPGVVKNVYNLNDKQIVKLFSRILNCNQDDMVQDLEQ-GDVSETVRMFFEESKSFPPS 366

  Fly   139 KQSKLYLQEVEEMLLHLVERTKEDEQTDLLQKLCSKATDLDLRTFIRLVKHDLRINARARHILDA 203
            .:|.|.:|||:..|..|.:.||||:|...||.:..|.|..||:.:||||||||:||:.|:|||||
Zfish   367 AKSLLTIQEVDASLSRLSQLTKEDDQQAELQSIAKKCTGNDLKCYIRLVKHDLKINSGAKHILDA 431

  Fly   204 FGPDAYPAYQSSRDLVAIVEQ-FATKENKNYASSPVKKTKKTSSSAIQVMTPISPMLASPCKSVE 267
            ..|:||.|:::||:|..:::: ...:::.:..:.|    :|..|....:|||:.||||..|||:|
Zfish   432 VDPNAYDAFKASRNLGDVIDRVLRNQQDASNGTGP----RKILSIEASLMTPVQPMLAEACKSIE 492

  Fly   268 DAFKKSPTGLYSEIKYDGERVQIHKQGNDFKFFSRNLKPVVDHKIRALKKYIPQAFPGGGEMILD 332
            .|.||.|.|:||||||||||||:||.||.|.:|||:||||:.||:...|.:|||||.||..||||
Zfish   493 YAMKKCPNGMYSEIKYDGERVQVHKNGNHFSYFSRSLKPVLPHKVAHFKDFIPQAFAGGHSMILD 557

  Fly   333 SEIILVDTDTGALLPFGSLGAHKKQTFANAAVCLFVFDCILYDGEDLTQLPFRKRREILEQNIQP 397
            :|::|:||.|...||||:||.|||..|.:|.|.|||||||.::|..|...|..:||:.|..|:..
Zfish   558 AEVLLIDTKTSKPLPFGTLGVHKKAAFQDAQVGLFVFDCIYFNGVSLMDKPLCERRKFLHDNMVE 622

  Fly   398 IKSHVQLSESEFLKTTRELAAMTARVLHANLEGVVLKSPTSTYQPGKRNWLKVKKDYLFDGKMAD 462
            :.:.:..||.:.:....:||.|..||:...|||:|||.....|:||||:|||||||||.:|.|||
Zfish   623 VPNRILFSEMKHVTRAPDLAEMITRVIREGLEGLVLKDIKGLYEPGKRHWLKVKKDYLNEGAMAD 687

  Fly   463 TADLVVLGAWYGSGKKGGTLSIFLMGCYDAFGRLWKTVTKVHSGLDDATNAEVHKSLIKLTERAD 527
            |||||||||:||.|..||.:|.|||||||...|.|.||||...|.|||....:.|.|..:....|
Zfish   688 TADLVVLGAFYGKGSNGGIMSSFLMGCYDPESRKWCTVTKCSGGFDDAMLDRLQKDLDVIKIGKD 752

  Fly   528 ANAIPSWLLCSKSLVPDVLAKDPMKMPVWEITGAEFTKSDAHTASGISVRFPRITRRRSDKSAKE 592
            .:.||.||...|:..||.:.:||.|.||||||||||:||:.|||.|||:||||.||.|.||..|.
Zfish   753 PSKIPGWLKIVKNYYPDFIIRDPQKAPVWEITGAEFSKSEMHTADGISIRFPRCTRMRDDKDWKT 817

  Fly   593 ANDLAHLEDLFEASKSNVNVDLLLANCSKDETAMNNKTTPEKEKKLNGNQSNGS----------- 646
            |.:|..|::|:..||.         ||..:.||..:|.. :.:|..:|.:|.||
Zfish   818 ATNLQQLKELYRISKE---------NCDFEVTAGPSKAN-QNDKSSSGGESGGSSPSASRGASTA 872

  Fly   647 KKLKRSNT----GSDDEDGAPVL-----SKRKESKAIRSLSPSQKGLKDFFKPSKEFKSVVKKEP 702
            .|.|..:|    .:..|..||.:     :::::.|.|::.|....|       ..:.|||...:|
Zfish   873 NKPKNGHTPKAKAAKTESSAPAVKRKLPAEKQDVKKIKTESVHSNG-------QSKLKSVPTTDP 930

  Fly   703 KEDEGNIESTSSKPQLFEGLVAHFAME-KDSSKLMQQFSQHGGCCTTEPQKADLVFYANTNEALD 766
            |:::..::       :|.|:..:.... ||..||.:.|..:.|         |||  ...:.||
Zfish   931 KQEKTLLD-------IFTGVKLYLPESVKDFEKLRRYFLAYDG---------DLV--PEYDSAL- 976

  Fly   767 LEKLRTLYR----RSCRHLNVSWLQSCLDTQSRQPFP 799
              ...||.:    .|.:.:..:|:..|:  :.|:..|
Zfish   977 --ATHTLGQPEDGSSAQKVTSNWIWECI--RKRRVVP 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig3	NP_650187.2	DNA_ligase_A_N	36..200	CDD:282522	78/163 (48%)
		dnl1	88..604	CDD:273147	266/516 (52%)
		Adenylation_DNA_ligase_III	242..454	CDD:185712	111/211 (53%)
		OBF_DNA_ligase_III	460..598	CDD:153436	78/137 (57%)
lig3	NP_001025345.2	zf-PARP	95..178	CDD:279039
		DNA_ligase_A_N	263..428	CDD:282522	78/165 (47%)
		dnl1	317..829	CDD:273147	266/516 (52%)
		Adenylation_DNA_ligase_III	467..679	CDD:185712	111/211 (53%)
		OBF_DNA_ligase_III	685..823	CDD:153436	78/137 (57%)
		LIG3_BRCT	935..1006	CDD:293364	18/93 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595077
Domainoid	1	1.000	220	1.000	Domainoid score	I2569
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H32109
Inparanoid	1	1.050	579	1.000	Inparanoid score	I999
OMA	1	1.010	-	-		QHG52366
OrthoDB	1	1.010	-	-		D189866at33208
OrthoFinder	1	1.000	-	-		FOG0009220
OrthoInspector	1	1.000	-	-		oto40927
orthoMCL	1	0.900	-	-		OOG6_106861
Panther	1	1.100	-	-	LDO	PTHR45674
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3850
SonicParanoid	1	1.000	-	-		X6002
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800