DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig3 and lig3

DIOPT Version :9

Sequence 1:	NP_650187.2	Gene:	DNAlig3 / 41518	FlyBaseID:	FBgn0286075	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	XP_012827218.2	Gene:	lig3 / 549105	XenbaseID:	XB-GENE-5788004	Length:	982	Species:	Xenopus tropicalis

Alignment Length:	787	Identity:	335/787 - (42%)
Similarity:	467/787 - (59%)	Gaps:	59/787 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NEDNKLDTFRRICDEIAGESSYLKKAERLQRFFEKGSSGKGFKGDTVLWVQFLIPAANQRVYNLQ 92
            ::|..|..||::|..:|.:.||..|.:.::.|..||:||.||.|||.|.|:.|:|...:.||||.
Frog   222 HKDCLLREFRKLCAMVAEQPSYNSKTQIIRDFLTKGTSGDGFHGDTYLTVKLLLPGVIKSVYNLN 286

  Fly    93 NKALIKLFSRIFNADQQQMHLDLEQDGDVSETLRKHFAASKKLKPQKQSKLYLQEVEEMLLHLVE 157
            :|.::|.||||||.:|::|..|||| ||||||:|..|..||...|..:|.|.:.||:::|..|.:
Frog   287 DKQIVKHFSRIFNCNQEEMVRDLEQ-GDVSETVRIFFEESKCFAPASKSLLTIHEVDDLLTKLSK 350

  Fly   158 RTKEDEQTDLLQKLCSKATDLDLRTFIRLVKHDLRINARARHILDAFGPDAYPAYQSSRDLVAIV 222
            .|||::|.::|:.:..:.|..||:..|||:||||::|:.|:|:|||..|:||.|:::||:|..:|
Frog   351 MTKEEDQQNVLEDIAHRCTSNDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYDAFKASRNLGDVV 415

  Fly   223 EQFATKENKNYASSPVKKTKKTSSSAIQVMTPISPMLASPCKSVEDAFKKSPTGLYSEIKYDGER 287
            |:....|.:      ....|:|.|....:|||:.||||..|||:|.|.||.|.|:|:||||||||
Frog   416 ERVLRNEQQ------APGMKRTLSVQASLMTPVQPMLAEACKSIEYAMKKCPNGMYAEIKYDGER 474

  Fly   288 VQIHKQGNDFKFFSRNLKPVVDHKIRALKKYIPQAFPGGGEMILDSEIILVDTDTGALLPFGSLG 352
            ||:||.|:.|.:|||:||||:.||:...|.:||:|||||..||||:|::|:||:||..||||:||
Frog   475 VQVHKNGDHFSYFSRSLKPVLPHKVAHFKDFIPKAFPGGNSMILDAEVLLIDTNTGKPLPFGTLG 539

  Fly   353 AHKKQTFANAAVCLFVFDCILYDGEDLTQLPFRKRREILEQNIQPIKSHVQLSESEFLKTTRELA 417
            .|||..|.:|.|||||||||.::|..|...|..:||:.:..|:..|.:|:..||.:.:....:||
Frog   540 VHKKAAFKDANVCLFVFDCIYFNGVSLMDRPLSERRKFMRDNMVEIPNHILFSEMKHVTKASDLA 604

  Fly   418 AMTARVLHANLEGVVLKSPTSTYQPGKRNWLKVKKDYLFDGKMADTADLVVLGAWYGSGKKGGTL 482
            .|..||:...|||:|||...|.|:||||:|||||||||.:|.|||||||.||||:||.|..||.:
Frog   605 DMITRVIREGLEGLVLKDLKSNYEPGKRHWLKVKKDYLNEGAMADTADLAVLGAYYGKGANGGIM 669

  Fly   483 SIFLMGCYDAFGRLWKTVTKVHSGLDDATNAEVHKSLIKLTERADANAIPSWLLCSKSLVPDVLA 547
            |||||||||...:.|.||||..||.||||...:.|.|..:....|.:.|||||..:|:..||.:.
Frog   670 SIFLMGCYDPESQKWCTVTKCSSGYDDATLQRLQKELNMVKISKDPSKIPSWLKINKNYFPDFII 734

  Fly   548 KDPMKMPVWEITGAEFTKSDAHTASGISVRFPRITRRRSDKSAKEANDLAHLEDLFEAS--KSNV 610
            .||.|.|:|||||||::|::||||:|:|:||||.||.|.||..|.|..|..|::|:..|  ||:.
Frog   735 HDPKKAPIWEITGAEYSKAEAHTAAGLSIRFPRCTRFRDDKDWKTATTLQQLKELYRLSKEKSDF 799

  Fly   611 NVDLLLANCSKDETAMNNKTTPEKEKKLNGNQSNGSKKLKRSNTGSDDEDGAPVLSKRKESKAIR 675
            |:   .|..|:||...:..::.|.|.  |..|:.....:|:|........|     |.|.|::.:
Frog   800 NI---TATSSQDEDGSSESSSRENEG--NSRQTASGSMVKKSKNAPSKSPG-----KDKTSESTK 854

  Fly   676 SLSPSQKGLKDFF-----KPSKEFKSVVKKEPKEDE---GNIESTSSKP-------QLFEGLVAH 725
             |.|.||  |:..     :.|:..|:|..|:.|..|   .|..|.:..|       .:|.|:..|
Frog   855 -LPPPQK--KEELPKAEKRKSQTPKTVQSKKAKISETGHSNGHSIAQSPVANKTLLDIFTGVKLH 916

  Fly   726 FAMEKDS-SKLMQQFSQHGGCCTTEPQKADLVFYANTNEALDLEKLRTLYRR------SCRHLNV 783
            .....|. :||.:.|....|         |||      ...||.....:..|      ..:|:..
Frog   917 IPSTLDDFAKLRRYFIAFDG---------DLV------PEYDLPTATHVMGREPECIADAKHVTP 966

  Fly   784 SWLQSCL 790
            .|:..|:
Frog   967 HWIWECI 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig3	NP_650187.2	DNA_ligase_A_N	36..200	CDD:282522	73/163 (45%)
		dnl1	88..604	CDD:273147	263/515 (51%)
		Adenylation_DNA_ligase_III	242..454	CDD:185712	114/211 (54%)
		OBF_DNA_ligase_III	460..598	CDD:153436	77/137 (56%)
lig3	XP_012827218.2	zf-PARP	64..149	CDD:395520
		dnl1	282..791	CDD:273147	263/515 (51%)
		LIG3_BRCT	905..977	CDD:407027	17/84 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	232	1.000	Domainoid score	I2378
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H32109
Inparanoid	1	1.050	592	1.000	Inparanoid score	I969
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D189866at33208
OrthoFinder	1	1.000	-	-		FOG0009220
OrthoInspector	1	1.000	-	-		oto105494
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3850
SonicParanoid	1	1.000	-	-		X6002
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090