Protein Alignment DNAlig3 and LIG4

DIOPT Version :10

• Sequence 1: NP_650187.2
• Gene: DNAlig3 / 41518
• FlyBaseID: FBgn0286075
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: NP_001339533.1
• Gene: LIG4 / 3981
• HGNCID: 6601
• Length: 923
• Species: Homo sapiens
• Alignment Length: 842
• Identity: 205/842 - (24%)
• Similarity: 344/842 - (40%)
• Gaps: 157/842 - (18%)

  Fly    52 KAERLQRFFEKGSSGKGF--------KGDTVLW---VQFLIPAANQR--VYNLQNKALIKLFSRI 103
            :||:::.|.|...|.:.|        |..|..:   ::.::|...:.  .|.::...|.||:..:
Human    44 RAEKIRHFREFLDSWRKFHDALHKNHKDVTDSFYPAMRLILPQLERERMAYGIKETMLAKLYIEL 108

  Fly   104 FNADQQQMHLDLEQDGDVSETLRKH------------FA--ASKKLKPQ--KQSKLYLQEVEEML 152
            .|         |.:||..:..|..:            ||  |...|||:  ::..|.:|:|.: |
Human   109 LN---------LPRDGKDALKLLNYRTPTGTHGDAGDFAMIAYFVLKPRCLQKGSLTIQQVND-L 163

  Fly   153 LHLVERTKEDEQTDLLQK----LCSKATDLDLRTFIRLVKHDLRINARARHILDAFGPDAYPAYQ 213
            |..:......::.||::|    |.::::.|:.:..||::..||::....:.|...|..||...:.
Human   164 LDSIASNNSAKRKDLIKKSLLQLITQSSALEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHN 228

  Fly   214 SSRDLVAIVEQFATKENKNYASSPVKKTKKTSSSAIQVMTPISPMLA--SPCKSVEDAFKKSPTG 276
            .:.||..:..|.         ..|   :...|..:|.:.:...||||  :..:.:|...|..  .
Human   229 VTTDLEKVCRQL---------HDP---SVGLSDISITLFSAFKPMLAAIADIEHIEKDMKHQ--S 279

  Fly   277 LYSEIKYDGERVQIHKQGNDFKFFSRNLKPVVDH-----KIRALKKYIPQAFPGGGEM-ILDSEI 335
            .|.|.|.||||:|:||.|:.:|:||||.....|.     ...:|..:|..||....:: |||.|:
Human   280 FYIETKLDGERMQMHKDGDVYKYFSRNGYNYTDQFGASPTEGSLTPFIHNAFKADIQICILDGEM 344

  Fly   336 ILVDTDTGALLPFGSLGAHKKQT-FANAAVCLFVFDCILYDGEDLTQLPFRKRREILEQNIQPIK 399
            :..:.:|...:..|:....|:.. .::...|..|||.::.:.:.|.....|||.|||.....||.
Human   345 MAYNPNTQTFMQKGTKFDIKRMVEDSDLQTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIP 409

  Fly   400 SHVQLSESEFLKTTRELAAMTARVLHANLEGVVLKSPTSTYQPGKR--NWLKVKKDYLFDGKMAD 462
            ..:::.:.....|..|:.......:....||:::|.|.|.|:|.||  .|||:|.:|: .|.| |
Human   410 GRIEIVQKTQAHTKNEVIDALNEAIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYV-SGLM-D 472

  Fly   463 TADLVVLGAWYGSGKKGGTLSIFLMGCYD-----AFGRLWKTVTKVHSGLDDATNAEVHKSLIKL 522
            ..|::::|.::|.|.:||.:|.||....:     ....::.|:::|.||.......::...|.|.
Human   473 ELDILIVGGYWGKGSRGGMMSHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKY 537

  Fly   523 TERADANAIPSWLLCSKSLVPDVLAKDPMKMPVWEITGAEFTKSDAHTASGISVRFPRITRRRSD 587
            .:.....|.||.:||... .|:|.. :|....:.:|..||...||.: .:|.::|||||.:.|.|
Human   538 WKPFHRKAPPSSILCGTE-KPEVYI-EPCNSVIVQIKAAEIVPSDMY-KTGCTLRFPRIEKIRDD 599

  Fly   588 KSAKEANDLAHLEDL-FEASKSNVNVDLLLANCSKDETAMNNKTTPEKEKKLNG--------NQS 643
            |...|...|..||.| .:||....:..|.:.  ..||.....:....|.||:.|        |.:
Human   600 KEWHECMTLDDLEQLRGKASGKLASKHLYIG--GDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLT 662

  Fly   644 NGSKKLKRSNTGSD---------DEDGAPVLSKR----------------------KESKAIRSL 677
            |.:   |.||...|         |....|.|..|                      .|:..::::
Human   663 NVN---KISNIFEDVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNI 724

  Fly   678 SPSQKGLKDFFKPS-----KEFKSVVKKEPKEDEGNIESTSSKPQLFEGLVAHFAME-------- 729
            ..|.|  .|..||:     .:.||.|..:|:.......||..          |||.|
Human   725 ILSNK--HDVVKPAWLLECFKTKSFVPWQPRFMIHMCPSTKE----------HFAREYDCYGDSY 777

  Fly   730 ---KDSSKLMQQFSQHGGCCTTEPQK-----ADLVF-YANTNEALDLEKLRTLYRRSCRHLN 782
               .|.::|.:.||.........|::     |||.: |:.....|.:.:..|:|..|...:|
Human   778 FIDTDLNQLKEVFSGIKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAVIN 839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig3	NP_650187.2	dnl1	88..604	CDD:273147	147/552 (27%)
LIG4	NP_001339533.1	dnl1	93..614	CDD:273147	146/549 (27%)
		BRCT_DNA_ligase_IV_rpt1	670..757	CDD:349354	15/88 (17%)
		DNA_ligase_IV	762..795	CDD:463272	9/42 (21%)
		BRCT_DNA_ligase_IV_rpt2	825..912	CDD:349349	4/15 (27%)