DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig3 and LIG1

DIOPT Version :9

Sequence 1:	NP_650187.2	Gene:	DNAlig3 / 41518	FlyBaseID:	FBgn0286075	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_000225.1	Gene:	LIG1 / 3978	HGNCID:	6598	Length:	919	Species:	Homo sapiens

Alignment Length:	439	Identity:	130/439 - (29%)
Similarity:	195/439 - (44%)	Gaps:	92/439 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 PISPMLASPCKSVEDAFKKSPTGLYS-EIKYDGERVQIHK-QGNDFKFFSRNLK------PVVDH 310
            |:.||||.|.:.:.:..|:.....:: |.||||:|.|||. :|.:.|.||||.:      |.:..
Human   539 PLKPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIIS 603

  Fly   311 KIRALKKYIPQAFPGGGEMILDSEIILVDTDTGALLPFGSLGAHKKQ----TFANAAVCLFVFDC 371
            :|..:|      .|.....|||:|.:..|.:...:.||..|...|::    :.....|||:.||.
Human   604 RIPKIK------LPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDL 662

  Fly   372 ILYDGEDLTQLPFRKRREILEQNIQPIKSHVQLSESEFLKTTRELAAMTARVLHANLEGVVLKS- 435
            |..:||.|.:.|..:||::|.:|....:.....:.|...|...::|....:.:..:.||:::|:
Human   663 IYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCEGLMVKTL 727

  Fly   436 -PTSTYQPGKR--NWLKVKKDYLFDGKMADTADLVVLGAWYGSGKKGGTLSIFLMGCYDAFGRLW 497
             ..:||:..||  ||||:||||| || :.||.||||:||:.|.||:.|....||:..||......
Human   728 DVDATYEIAKRSHNWLKLKKDYL-DG-VGDTLDLVVIGAYLGRGKRAGRYGGFLLASYDEDSEEL 790

  Fly   498 KTVTKVHSGLDDATNAEVHKSLIKLT-------ERADANAIPS-WLLCSKSLVPDVLAKDPMKMP 554
            :.:.|:.:|..|....|.|:||..|.       .|.|...||. ||             ||  ..
Human   791 QAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWL-------------DP--SA 840

  Fly   555 VWEITGAEFTKSDAHTAS--------GISVRFPRITRRRSDKSAKEANDLAHLEDLFEASKSNVN 611
            |||:..|:.:.|..:.|:        |||:||||..|.|.||..::|...|.:..|:
Human   841 VWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLY-------- 897

  Fly   612 VDLLLANCSKDETAMNNKTTPEKEKKLNGNQSNGSKKLKRSNTGSDDED 660
                                 .|:.::...|...|        |||.||
Human   898 ---------------------RKQSQIQNQQGEDS--------GSDPED 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig3	NP_650187.2	DNA_ligase_A_N	36..200	CDD:282522
		dnl1	88..604	CDD:273147	122/381 (32%)
		Adenylation_DNA_ligase_III	242..454	CDD:185712	65/215 (30%)
		OBF_DNA_ligase_III	460..598	CDD:153436	50/153 (33%)
LIG1	NP_000225.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..270
		DUF4045	<10..275	CDD:330572
		CDC9	164..914	CDD:330238	126/434 (29%)
		Interaction with target DNA	449..458
		Interaction with target DNA	642..644		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274264at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820