Protein Alignment DNAlig3 and DNAlig4

DIOPT Version :10

• Sequence 1: NP_650187.2
• Gene: DNAlig3 / 41518
• FlyBaseID: FBgn0286075
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: NP_572907.1
• Gene: DNAlig4 / 32322
• FlyBaseID: FBgn0030506
• Length: 918
• Species: Drosophila melanogaster
• Alignment Length: 856
• Identity: 204/856 - (23%)
• Similarity: 334/856 - (39%)
• Gaps: 228/856 - (26%)

  Fly    36 FRRIC---DEIAGESSYLKKAERLQRFFEKGSSGK-GFKGDTVL--------------WVQFLIP 82
            ||.||   ::|........|.|.|:.::|.....: .|:..|.|              .::.|:|
  Fly    11 FRDICSLFEKIKATQKVANKEEVLKSYYESFCRHRESFRRQTGLNNDQPEDGASSFYSVLRLLLP 75

  Fly    83 AAN--QRVYNLQNKALIKLFSRIF-----NADQ---QQMHLDLEQD-GDVSETLRKHFAASKKLK 136
            .|:  :..|.||..||.:|:.|:.     ::|.   |..:.::.:| |||..::         ||
  Fly    76 GADTGRDTYGLQITALGRLYIRVLQLPTDSSDAIRLQHRNGNMYRDYGDVVYSV---------LK 131

  Fly   137 PQ---KQSKLYLQEVEEMLLHLVERTKEDEQTDLLQKLCSKATDLDLRTFIRLVKHDLRINARAR 198
            |:   ..|.|.|:|:.:||..:.....|.:|..|: :...:|:..:.:..|||:...|.:....:
  Fly   132 PRCFNPPSNLRLKEIHQMLDTIANEDTEVKQQQLI-RFTEQASPEEQKWLIRLLLKSLGLGIGEQ 195

  Fly   199 HILDAFGPDAYPAYQSSRDLVAIVEQFATKENKNYASSPVKKTKKTSSSAIQ------VMTP--- 254
            .|.....|.|...||...||..:....|.:.....|||     .|.|.:|::      |:.|
  Fly   196 KIFGVLHPKAQDIYQRCSDLGHVCNLLADRTTDLDASS-----SKDSKAAVKFVNLNSVIRPFHQ 255

  Fly   255 ISPMLASPCK----SVEDAFKKSPTGLYSEIKYDGERVQIHKQGNDFKF-------FSRNLKPVV 308
            |.|||   |:    .:::..:...  ||.|.|.||||.|:|.....|.:       ::||.....
  Fly   256 IRPML---CERFPGDIQELMQSDV--LYLETKMDGERFQLHIDRGRFMYISRNGVDYTRNFGHSY 315

  Fly   309 DH-----KIRALKKYIPQAFPGGGE-MILDSEIILVD------------TDTGALLPFGSLGAHK 355
            ||     |:|.|       .|.|.| :|||.|:::.|            ||..:|.|.||.
  Fly   316 DHGTLTPKLRGL-------LPLGLESIILDGEMMVWDTNKLRFREKGENTDVKSLKPEGSW---- 369

  Fly   356 KQTFANAAVCLFVFDCILYDGEDLTQLPFRKRREILEQNIQPIKSHVQLSESEFLKTTRELAAMT 420
                   ..|..|:|.:.::|:.|....:.:|...|::.|......:||..:..:.:.:|...:.
  Fly   370 -------QPCFVVYDLLYFNGQSLLDHTYIQRAYKLQKLIVEQSGVLQLMRARKIGSVQEFNELF 427

  Fly   421 ARVLHANLEGVVLKSPTSTYQPGKR---NWLKVKKDYLFDGKMADTADLVVLGAWYGSGKKGGTL 482
            .:.|.::.||:|||...|.||||.|   .|.|.|.||: .|.:.: .|::::||:|  .:|...:
  Fly   428 QQALDSHAEGIVLKKQGSRYQPGVRLGGGWYKDKADYI-KGLITE-FDVLIIGAFY--NRKRTFV 488

  Fly   483 SIFLMGCYD-------------AFGRLWKTVTKVHSGLDDATNAEVHKSL---------IKLTER 525
            ..||:|...             :.|.:... ||....|:.......|..:         .|..||
  Fly   489 DSFLLGVLQPAPPGSSNRPEVFSIGVVANN-TKQRGVLNHTLKPHWHDVVNEPPPLWFHYKPKER 552

  Fly   526 ADANAIPSWLLCSKSLVPDVLAKD--PMKMPVWEITGAEFTKSDAHTASGISVRFPRITRRRSDK 588
            :....:  |:....|::..|.|.|  |        .||.||:...|        |||...:|.||
  Fly   553 SGCPDL--WIEPQNSVILQVKAADLAP--------NGAFFTRKSLH--------FPRTEMKRDDK 599

  Fly   589 SAKEANDLAHLEDLFEASKSNVNVDLLLANCSKDETAMNNKTTPEKEKKLNGNQSNGSKKLKRSN 653
            :..|...|....||                |.          .|...||||      .::|:.
  Fly   600 TWSECMTLKEFNDL----------------CG----------GPLAIKKLN------KRQLRL-- 630

  Fly   654 TGSDDEDGAPVLSKRKESKAIRSLSPSQK---GLKDFFKPSKEFKSVVKKEPKEDEGNIESTSSK 715
                 ||   |.:|||:.:    ::||::   ||..:             |.:.|.....|||
  Fly   631 -----ED---VTTKRKQMR----MTPSERSRLGLAVY-------------EKRYDASTSASTS-- 668

  Fly   716 PQLFEGL---VAHFAMEKDSSKLMQQFS-QHGGCCTTEPQKAD-LVFYANTNEALDLEKLRTLYR 775
             :||:||   :...:..:.|...:|:.: ::|||....|...| ..|....:|...:::|.....
  Fly   669 -KLFDGLSFCILSGSAGRHSKHQLQELAVKNGGCIVENPLPNDPKCFCIAGDETFLVKRLILQQP 732

  Fly   776 RSCRHLNVSWL 786
            |:|..:.:.||
  Fly   733 RTCDIVRMEWL 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig3	NP_650187.2	dnl1	88..604	CDD:273147	149/592 (25%)
DNAlig4	NP_572907.1	dnl1	84..613	CDD:273147	147/589 (25%)
		Adenylation_DNA_ligase_IV	249..466	CDD:185713	67/240 (28%)
		BRCT	670..760	CDD:469589	18/74 (24%)
		BRCT_2	830..917	CDD:465186