DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNAlig3 and K07C5.3

DIOPT Version :9

Sequence 1:	NP_650187.2	Gene:	DNAlig3 / 41518	FlyBaseID:	FBgn0286075	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_505659.1	Gene:	K07C5.3 / 179441	WormBaseID:	WBGene00010626	Length:	493	Species:	Caenorhabditis elegans

Alignment Length:	249	Identity:	64/249 - (25%)
Similarity:	121/249 - (48%)	Gaps:	31/249 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NEDNKLDTFR---RICDEIAGESSYLKKAERLQRFFEKGSSGKGFKGDTVLWVQFLIPAANQRVY 89
            ||::..::|.   ::|..:...|...:|:..:....:|    |.|.||.:||:.|||..::||.|
Worm   158 NEESDFNSFYKFVKVCSVLKEISVKSEKSAVITSLLQK----KNFDGDLMLWLTFLIRESDQRSY 218

  Fly    90 NLQNKALIKLFSRIFNADQQQMHLDLEQDGDVSETLRKHFAASKKLKPQKQSKLYLQEVEEMLLH 154
            |:.::.||:.|::|.:..:.::...:.:..|::.:: .| |..||:..:| .|..||:::..|..
Worm   219 NITDEKLIQYFAKILDMGESKIQKYVTKSNDIALSI-SH-AHEKKVTNEK-GKWSLQKLDRYLEK 280

  Fly   155 LVERTKEDEQTDLLQKLCSKATDLDLRTFIRLVKHDLRINARARHILDAFGPDAYPAYQSSRDLV 219
            |.:...:|.....|:....:....:|...|||::.:|..:|.|..||....|.|...:||: .|.
Worm   281 LSKIEDDDAILSHLKFAAKRMRHDELDILIRLIRKELDTDADASIILKGVHPKAPEIFQSN-GLD 344

  Fly   220 AIVEQFATKENKNYASSPVKKTKKTSSSAIQVMTPISPMLASPCKSVEDAFKKS 273
            :::|::...:.:..|.      :|||||..:|..|              :||||
Worm   345 SVIEKYYNNDFEKSAQ------QKTSSSKNKVAEP--------------SFKKS 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig3	NP_650187.2	DNA_ligase_A_N	36..200	CDD:282522	42/166 (25%)
		dnl1	88..604	CDD:273147	46/186 (25%)
		Adenylation_DNA_ligase_III	242..454	CDD:185712	11/32 (34%)
		OBF_DNA_ligase_III	460..598	CDD:153436
K07C5.3	NP_505659.1	zf-PARP	12..102	CDD:366219
		DNA_ligase_A_N	165..317	CDD:377398	39/158 (25%)
		MSCRAMM_SdrC	<358..451	CDD:380146	12/41 (29%)
		zf-CCHH	469..490	CDD:370948
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157574
Domainoid	1	1.000	58	1.000	Domainoid score	I7188
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3614
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106861
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3850
SonicParanoid	1	1.000	-	-		X6002
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.620