DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig3 and lig-4

DIOPT Version :9

Sequence 1:	NP_650187.2	Gene:	DNAlig3 / 41518	FlyBaseID:	FBgn0286075	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001367462.1	Gene:	lig-4 / 176067	WormBaseID:	WBGene00002986	Length:	741	Species:	Caenorhabditis elegans

Alignment Length:	836	Identity:	171/836 - (20%)
Similarity:	299/836 - (35%)	Gaps:	204/836 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DNKLDTFRRICDEIAGESSYLKKAERLQRFFEKGSSGKGFKGDTVLWVQFLIPAANQ-RVYNLQN 93
            |..:|.|    ::|...|:...|....|:.||..........|..:.::|.:....: |.:::..
Worm     8 DEVVDVF----NKIRRTSNVKSKQATFQKNFESWKEKCSDPSDMFVIIRFFVSDYERFRKFDMGP 68

  Fly    94 KALIKLFSRIFNADQQQMHLDLEQDGDVSETLRKHFAASKKLKPQKQSKLY-----------LQE 147
            ..|....::.|:          :...|...|:.|..:.:.:...:|.|:.|           :.|
Worm    69 TKLASFMAKTFH----------DVRADYVSTISKDASTAARQLAEKISEEYRTENDESTVVTVSE 123

  Fly   148 VEEMLLHLVERTKED-EQTDLLQKLCSKATDLDLRTFIRLVKHDLR--INARARHILDAFGPDAY 209
            :.|:|..|.....:| .:.|.:.||..:.::.:|.....::..::.  :.|.:..|||...|.|.
Worm   124 LNEILDFLAAGPMDDGNKRDKMSKLVKRCSEDELEWIFNVILKNVESALGAPSNRILDWISPSAC 188

  Fly   210 PAYQSSRDLVAIVEQFATKENKNYASSPVKKTKKTSSSAI-QVMTPISPMLASPCK------SVE 267
            ..:..:.||.|:::   .|..:|..::.:.:|.......: ::.|   |||....|      ::|
Worm   189 AIWDQTHDLKAVLK---GKLVENKGTNELGETNDDDDEHLFKIWT---PMLLQKQKRGDWYANIE 247

  Fly   268 DAFKKSPTGLYSEIKYDGERVQIHKQGNDFKFFSRN----LKPVVDHK--IRALKKYIPQAFPGG 326
               |......:.:.|:|||.|.:||:||::::|:||    .|...|..  |..|...|...|...
Worm   248 ---KFGGQKFFLQTKFDGENVLLHKKGNEYRWFTRNNNDFSKEYGDSSMAIGKLSSRIHSFFNKE 309

  Fly   327 GE-MILDSEIILVDTDTGALLPFGSLGA----------HKKQTFANAAVCLFVFDCILYDGEDLT 380
            .| .|.:.|::|.|..|..|........          |.|.. .|..:.:.:||.:..:|:...
Worm   310 CESAIFNCELMLWDKKTKKLCRHNDASTTSDAQVLSFRHVKPD-DNQQLTVVLFDLLYLNGKPFF 373

  Fly   381 QLPFRKRREILEQNIQPIK----------SHVQLSESEFLKTTRELAAMTARVLHANLEGVVLKS 435
            ..|..:|.|:|:  |.|:|          .|.:.|:.|.::...|:|      :..|.||:|:|.
Worm   374 GAPLHQRLEMLK--IAPLKKEREDTIFVAKHEEGSKKEDIQQFFEIA------MANNEEGIVVKR 430

  Fly   436 PTSTYQPGKRN----WLKVKKDYLFDGKMADTADLVVLGAWYGSGKKGGTLSIFLMGCYDAFGRL 496
            ..|.|..|:|:    |.|:|.....|..:    ||.::....|:|:.|.||  :....:|...:.
Worm   431 TDSVYVKGQRSASNGWFKLKPSASKDCDL----DLALVAVHPGAGRNGKTL--YRFAAFDEKTQD 489

  Fly   497 WKTVTKVHSGLDDATNAEVHKSLIKLTERADANAIPSWLLCSKSLVPDVL---AKDP-------- 550
            :|.......||.|.....:.....:|.|.|                |:.|   .|.|
Worm   490 YKLCLSCSYGLSDTVREAIRFEYGQLLEEA----------------PEELTFYGKRPKNIARGDG 538

  Fly   551 --MKMPVWEITGAEFTKSDAHTASGI---SVRFPRITRRRSDKSAKEANDLAHLEDLFEASKSNV 610
              :....|::...        |::|:   .:..|.:...|.||..::.|......|.
Worm   539 GYIDFERWQVIKI--------TSNGVRNGKLVDPVMREWRLDKPVEQVNTWEEFSDY-------- 587

  Fly   611 NVDLLLANCSKDETAMNNKTTPEKEKKLNGNQSNGSKKLKRSNTGSDDEDGAPVLSK--RKESKA 673
                               .|..:|.||..|..:..:         |.||..|...|  |...||
Worm   588 -------------------ATALQECKLGDNVDSDEE---------DSEDKKPDTLKVERITRKA 624

  Fly   674 IRSLSPSQKGLKDFFKPSKEFKSVVKKEPKEDEGNIESTSSKPQLFEGLVAHFAME-----KDSS 733
            |...:|.:      .|.:|...|:...|....:|..|:...|   .|.::.||...     ..|:
Worm   625 IHQSAPVR------LKRAKLESSLTGIEVAVLQGTSETIRRK---CEEILKHFDATVVKGITPST 680

  Fly   734 KLMQQFSQHGGCCTTEPQKADLVFYANTNEALDLEKLRTLYRRSCRHLNVSWLQSC 789
            ||         |..|.|:..    :..|.:|        :...||..|..:||:.|
Worm   681 KL---------CIATAPKST----HPKTAQA--------IASNSCTVLKPAWLERC 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig3	NP_650187.2	DNA_ligase_A_N	36..200	CDD:282522	28/178 (16%)
		dnl1	88..604	CDD:273147	120/583 (21%)
		Adenylation_DNA_ligase_III	242..454	CDD:185712	62/249 (25%)
		OBF_DNA_ligase_III	460..598	CDD:153436	27/153 (18%)
lig-4	NP_001367462.1	DNA_ligase_A_N	7..167	CDD:398380	29/172 (17%)
		Adenylation_DNA_ligase_IV	218..451	CDD:185713	61/247 (25%)
		OBF_DNA_ligase_family	459..582	CDD:415534	27/152 (18%)
		BRCT	644..731	CDD:412126	21/96 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D189866at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820