DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig3 and Lig3

DIOPT Version :9

Sequence 1:	NP_650187.2	Gene:	DNAlig3 / 41518	FlyBaseID:	FBgn0286075	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	XP_006532410.1	Gene:	Lig3 / 16882	MGIID:	109152	Length:	1066	Species:	Mus musculus

Alignment Length:	697	Identity:	320/697 - (45%)
Similarity:	429/697 - (61%)	Gaps:	47/697 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 TRLLCNKMASKGLHNEDNKLDTFRRICDEIAGESSYLKKAERLQRFFEKGSSGKGFKGDTVLWVQ 78
            |.|..:|...|   ::|..|..||::|..:|...||..|.:.:..|.:|||:|.||.||..|.|:
Mouse   303 TSLSASKCDPK---HKDCLLREFRKLCAMVAENPSYNTKTQIIHDFLQKGSTGDGFHGDVYLTVK 364

  Fly    79 FLIPAANQRVYNLQNKALIKLFSRIFNADQQQMHLDLEQDGDVSETLRKHFAASKKLKPQKQSKL 143
            .|:|...:.||||.:|.::||||||||.:...|..|||| ||||||:|..|..||...|..:|.|
Mouse   365 LLLPGVIKSVYNLNDKQIVKLFSRIFNCNPDDMARDLEQ-GDVSETIRIFFEQSKSFPPAAKSLL 428

  Fly   144 YLQEVEEMLLHLVERTKEDEQTDLLQKLCSKATDLDLRTFIRLVKHDLRINARARHILDAFGPDA 208
            .:|||:..||||.:.||||||...||.:.|:.|..||:..|||:||||::|:.|:|:|||..|:|
Mouse   429 TIQEVDAFLLHLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNA 493

  Fly   209 YPAYQSSRDLVAIVEQFATKENKNYASSPVKKTKKTSSSAIQVMTPISPMLASPCKSVEDAFKKS 273
            |.|:::||:|..:||:....|.:.......::..:..:|   :|||:.||||..|||:|.|.||.
Mouse   494 YEAFKASRNLQDVVERVLHNEQEVEKDPGRRRALRVQAS---LMTPVQPMLAEACKSIEYAMKKC 555

  Fly   274 PTGLYSEIKYDGERVQIHKQGNDFKFFSRNLKPVVDHKIRALKKYIPQAFPGGGEMILDSEIILV 338
            |.|::|||||||||||:||:|:.|.:|||:||||:.||:...|.|||:|||||..||||||::|:
Mouse   556 PNGMFSEIKYDGERVQVHKKGDHFSYFSRSLKPVLPHKVAHFKDYIPKAFPGGQSMILDSEVLLI 620

  Fly   339 DTDTGALLPFGSLGAHKKQTFANAAVCLFVFDCILYDGEDLTQLPFRKRREILEQNIQPIKSHVQ 403
            |.:||..||||:||.|||..|.:|.|||||||||.::...|...|..:||:.|..|:..|::.:.
Mouse   621 DNNTGKPLPFGTLGVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIRNRIM 685

  Fly   404 LSESEFLKTTRELAAMTARVLHANLEGVVLKSPTSTYQPGKRNWLKVKKDYLFDGKMADTADLVV 468
            .||.:.:....:||.|..||:...|||:|||....||:||||:|||||||||.:|.|||||||||
Mouse   686 FSEMKQVTKASDLADMINRVIREGLEGLVLKDVKGTYEPGKRHWLKVKKDYLNEGAMADTADLVV 750

  Fly   469 LGAWYGSGKKGGTLSIFLMGCYDAFGRLWKTVTKVHSGLDDATNAEVHKSLIKLTERADANAIPS 533
            |||:||.|.|||.:|||||||||...:.|.||||...|.||||.|.:.|.|:.:....|.:.|||
Mouse   751 LGAFYGQGSKGGMMSIFLMGCYDPDSQKWCTVTKCAGGHDDATLARLQKELVMVKISKDPSKIPS 815

  Fly   534 WLLCSKSLVPDVLAKDPMKMPVWEITGAEFTKSDAHTASGISVRFPRITRRRSDKSAKEANDLAH 598
            ||..:|...||.:..||.|..|||||||||::|:||||.|||:||||.||.|.||..|.|.:|..
Mouse   816 WLKINKIYYPDFIVPDPKKAAVWEITGAEFSRSEAHTADGISIRFPRCTRIRDDKDWKSATNLPQ 880

  Fly   599 LEDLFEASKSNVNVDLLLANCSKDETAMNN-------------KTTPEK--------EKKLNGNQ 642
            |::|::.||...:..::..:.:...|..::             |..|.|        |:|||...
Mouse   881 LKELYQLSKDKADFAVVAGDEASPTTGGSSGENEGTAGSAGPCKGPPSKSSASAKTTEQKLNSPS 945

  Fly   643 SNGSKKLKRSNTGSDDEDGAPVLS----KRKESKAIRSLSPSQKGLK 685
            |.|..|              |:..    |..|..|::| ||.:.|:|
Mouse   946 SRGGIK--------------PIPKHSPMKPGEKLAVKS-SPVKVGMK 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig3	NP_650187.2	DNA_ligase_A_N	36..200	CDD:282522	79/163 (48%)
		dnl1	88..604	CDD:273147	272/515 (53%)
		Adenylation_DNA_ligase_III	242..454	CDD:185712	112/211 (53%)
		OBF_DNA_ligase_III	460..598	CDD:153436	81/137 (59%)
Lig3	XP_006532410.1	zf-PARP	151..236	CDD:366219
		dnl1	374..886	CDD:273147	272/515 (53%)
		LIG3_BRCT	990..1061	CDD:374781
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849446
Domainoid	1	1.000	227	1.000	Domainoid score	I2504
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H32109
Inparanoid	1	1.050	578	1.000	Inparanoid score	I1025
Isobase	1	0.950	-	0	Normalized mean entropy	S3614
OMA	1	1.010	-	-		QHG52366
OrthoDB	1	1.010	-	-		D189866at33208
OrthoFinder	1	1.000	-	-		FOG0009220
OrthoInspector	1	1.000	-	-		oto95315
orthoMCL	1	0.900	-	-		OOG6_106861
Panther	1	1.100	-	-	LDO	PTHR45674
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3850
SonicParanoid	1	1.000	-	-		X6002
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750