Protein Alignment Sol1 and Cubn

DIOPT Version :10

• Sequence 1: NP_001097756.1
• Gene: Sol1 / 41513
• FlyBaseID: FBgn0085431
• Length: 695
• Species: Drosophila melanogaster
• Sequence 2: NP_445784.3
• Gene: Cubn / 80848
• RGDID: 68355
• Length: 3623
• Species: Rattus norvegicus
• Alignment Length: 659
• Identity: 143/659 - (21%)
• Similarity: 233/659 - (35%)
• Gaps: 190/659 - (28%)

  Fly    31 GNGQSQQAVTNSKQSHFWLDCSCLHLSERN-ATQW------GRLAINAS--HSLGAKNN------ 80
            ||.......|...|.|.......::..|:. ..||      |.::..|.  .|.|..|:
  Rat  1352 GNNMPPPGATTGSQLHVLFHTDGINSGEKGFKMQWFTHGCGGEMSGTAGSFSSPGYPNSYPHNKE 1416

  Fly    81 CLM-IFIA-GMDDELVAFQLEQLQLRAGC-LDSVDIFPYL--REPVIENATLAADTFCQHSRERS 140
            |:. |.:| |...:|.....: ::....| .||::|:..|  ..|.|..       .|..|...:
  Rat  1417 CIWNIRVAPGSSIQLTIHDFD-VEYHTSCNYDSLEIYAGLDFNSPRIAQ-------LCSQSPSAN 1473

  Fly   141 ATPIYSAGRLLGLRLRFQQPPTDLASWNLTLNASYRFLKRENFRTDGRLVPHSFCDFYFFASLSG 205
            ...:.|.|..|.:|.:     ||     .|||.       ..|....|.||.. |         |
  Rat  1474 PMQVSSTGNELAIRFK-----TD-----STLNG-------RGFNASWRAVPGG-C---------G 1511

  Fly   206 EEANMGQGYFHSPQFPAHYPAHIKCAYKFIGRPDTHVEILFE----ELQLPPVVSGGCQLDALTL 266
            ....:.:|..|||.:|.:|.|:.:|::  |.:.:.|..:|..    :|:.|.        ..||.
  Rat  1512 GIIQLSRGEIHSPNYPNNYRANTECSW--IIQVERHHRVLLNITDFDLEAPD--------SCLTT 1566

  Fly   267 FDAESAHMNSVIDVICSSRPTRRLVSTGPDLLLEFNASSNRTAKGFRGKYKFVSNDLGVPNASVP 331
            :|..|:....|..|....:|...::::|..|.:.|.:.|:...:|||.:::
  Rat  1567 YDGSSSTNARVASVCGRQQPPNSIIASGNSLFVRFRSGSSSQNRGFRAEFR-------------- 1617

  Fly   332 PPAVLEAASVVVKQEKLQQEQASAAKENSLMSDVELSKPGRSFEQCK---QTFDSRVNKSGIFDS 393
                                                       |:|.   .|..|....|.::..
  Rat  1618 -------------------------------------------EECGGRIMTDSSDTIFSPLYPH 1639

  Fly   394 NQLLLAKHALGGVVIGGSRVLQCRYEFEAQAP-ERVQIRFHDFNVPTEHENSTGCQPGDALHVV- 456
            |.|               ....|.:..|||.| ..:.:.|..|.:    :|||.| ..|.:.::
  Rat  1640 NYL---------------HNQNCSWIIEAQPPFNHITLSFTHFQL----QNSTDC-TRDFVEILD 1684

  Fly   457 -----TELRGRYETQELLCGAFLPKPLMSSGQQLHLQFVGKYPPTMTNKVQ-YYGFRAEYRFLTN 515
                 ..::|||      ||..||.|::|.|..|.::||       |:..: :.||||.|...|:
  Rat  1685 GNDYDAPVQGRY------CGFSLPHPIISFGNALTVRFV-------TDSTRSFEGFRAIYSASTS 1736

  Fly   516 FGIMSGIQKEGCSFVYNSSERISGLFHSPNFPGYYLENVVCNYYFYGASDERVVLHFTYFDIEGI 580
                      .|.   .|...:.|:|:||::|..|..|..|.:....:...|:.|.|..|::|..
  Rat  1737 ----------SCG---GSFYTLDGIFNSPDYPADYHPNAECVWNIASSPGNRLQLSFLSFNLENS 1788

  Fly   581 GSCDHQTASDYIEFSNFMSTDRKFSRYCG-KLPDFEMRSDGRFFRVTLHSNDRFVAIGFRALYTF 644
            .:|:    .|::|.....:|.....|||| .||.....::|....|...|:.....:||:|  .|
  Rat  1789 LNCN----KDFVEIREGNATGHLIGRYCGNSLPGNYSSAEGHSLWVRFVSDGSGTGMGFQA--RF 1847

  Fly   645 ETVSVNNSI 653
            :.:..||:|
  Rat  1848 KNIFGNNNI 1856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sol1	NP_001097756.1	CUB	195..318	CDD:238001	29/126 (23%)
		CUB	<414..512	CDD:238001	31/105 (30%)
		CUB	527..644	CDD:238001	31/117 (26%)
Cubn	NP_445784.3	cubilin_NTD	38..132	CDD:412063
		Interaction with AMN. /evidence=ECO:0000250|UniProtKB:O60494	39..46
		EGF_CA	133..164	CDD:238011
		EGF_CA	167..207	CDD:238011
		EGF_CA	260..301	CDD:214542
		EGF_3	306..344	CDD:463759
		EGF_3	350..387	CDD:463759
		EGF_CA	400..430	CDD:238011
		EGF_CA	432..468	CDD:238011
		CUB	474..585	CDD:238001
		CUB	590..699	CDD:238001
		CUB	708..815	CDD:238001
		CUB	817..927	CDD:238001
		CUB	932..1041	CDD:238001
		CUB	1048..1157	CDD:395345
		CUB	1165..1275	CDD:238001
		CUB	1278..1388	CDD:238001	8/35 (23%)
		CUB	1391..1505	CDD:238001	29/138 (21%)
		CUB	1510..1617	CDD:238001	29/125 (23%)
		CUB	1620..1733	CDD:238001	37/145 (26%)
		CUB	1738..1847	CDD:238001	31/117 (26%)
		CUB	1852..1962	CDD:238001	3/5 (60%)
		CUB	1978..2088	CDD:238001
		CUB	2092..2212	CDD:238001
		CUB	2217..2333	CDD:238001
		CUB	2336..2447	CDD:238001
		CUB	2452..2564	CDD:238001
		CUB	2570..2686	CDD:238001
		CUB	2689..2800	CDD:238001
		CUB	2805..2918	CDD:238001
		CUB	2920..3034	CDD:238001
		CUB	3037..3148	CDD:238001
		CUB	3157..3273	CDD:238001
		CUB	3278..3392	CDD:238001
		CUB	3395..3506	CDD:238001
		CUB	3511..3623	CDD:238001