DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34402 and CUBN

DIOPT Version :9

Sequence 1:	NP_001097756.1	Gene:	CG34402 / 41513	FlyBaseID:	FBgn0085431	Length:	695	Species:	Drosophila melanogaster
Sequence 2:	NP_001072.2	Gene:	CUBN / 8029	HGNCID:	2548	Length:	3623	Species:	Homo sapiens

Alignment Length:	604	Identity:	129/604 - (21%)
Similarity:	209/604 - (34%)	Gaps:	139/604 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 GRLLGLRLRFQQPPTDLASWNLTLNASYRFLKRENFRTDGRLVPHSFCDFYFFASLSGEEANMGQ 212
            ||..|:.|   .||....|..|.:          ...|||...........:|....|.|.:...
Human  1348 GRYCGVDL---PPPGSTTSSKLQV----------LLLTDGVGRREKGFQMQWFVYGCGGELSGAT 1399

  Fly   213 GYFHSPQFPAHYPAHIKCAYKFIGRPDTHVEILFEELQLPPVVSGGCQLDALTLFDAESAHMNSV 277
            |.|.||.||..||.:.:|.:.....|.:.:::...:..:.  ....|..|.|.::.....|...:
Human  1400 GSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVE--YHSRCNFDVLEIYGGPDFHSPRI 1462

  Fly   278 IDVICSSRPTR---RLVSTGPDLLLEFNASSNRTAKGFRGKYKFVSNDLG----VPNASVPPPAV 335
            .. :|:.|...   ::.|||.:|.:.|....:...:||...::.|:...|    .|:..:..|..
Human  1463 AQ-LCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGCGGIFQAPSGEIHSPNY 1526

  Fly   336 LEA------ASVVVKQEK------------LQQEQASAAKENSLMSDV----------ELSKP-- 370
            ...      .|.|::.::            |:.:.:.....:.|.|.:          :|:.|
Human  1527 PSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAYDGLSSTMSRLARTCGREQLANPIV 1591

  Fly   371 --GRSFEQCKQTFDSRVNKSGIFDSNQLLLAKHALGGVVIGGS--------------RVLQCRYE 419
              |.|.....|:..||.|:.  |.:.    .:.|.||.::..|              ....|.:.
Human  1592 SSGNSLFLRFQSGPSRQNRG--FRAQ----FRQACGGHILTSSFDTVSSPRFPANYPNNQNCSWI 1650

  Fly   420 FEAQAP-ERVQIRFHDFNVPTEHENSTGCQPG-----DALHVVTELRGRYETQELLCGAFLPKPL 478
            .:||.| ..:.:.|..|    |.|.||.|...     |..|....|||||      ||..:|.|:
Human  1651 IQAQPPLNHITLSFTHF----ELERSTTCARDFVEILDGGHEDAPLRGRY------CGTDMPHPI 1705

  Fly   479 MSSGQQLHLQFV-------GKYPPTMTNKVQYYGFRAEYRFLTNFGIMSGIQKEGCSFVYNSSER 536
            .|....|.|:||       |.:..|:|..|                       ..|...:..:|
Human  1706 TSFSSALTLRFVSDSSISAGGFHTTVTASV-----------------------SACGGTFYMAE- 1746

  Fly   537 ISGLFHSPNFPGYYLENVVCNYYFYGASDERVVLHFTYFDIEGIGSCDHQTASDYIEFSNFMSTD 601
              |:|:||.:|..|..||.|.:....:...|:.|.|..|.:|....|    :.|::|.....:|.
Human  1747 --GIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDC----SRDFVEIREGNATG 1805

  Fly   602 RKFSRYCGKLPDFEMRSD---GRFFRVTLHSNDRFVAIGFRALYTFETVSVNNSITDLRDNASM- 662
            ....||||.  .|.:...   |....|...|:......||:|  ||..:..|::|.......:.
Human  1806 HLVGRYCGN--SFPLNYSSIVGHTLWVRFISDGSGSGTGFQA--TFMKIFGNDNIVGTHGKVASP 1866

  Fly   663 ---QSFVSTASTQPVANVN 678
               :::...::.|...|||
Human  1867 FWPENYPHNSNYQWTVNVN 1885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34402	NP_001097756.1	CUB	195..318	CDD:238001	26/125 (21%)
		CUB	<414..512	CDD:238001	31/110 (28%)
		CUB	527..644	CDD:238001	31/119 (26%)
CUBN	NP_001072.2	Interaction with AMN. /evidence=ECO:0000269\|PubMed:30523278	42..49
		EGF_CA	136..167	CDD:238011
		EGF_CA	170..210	CDD:238011
		EGF_CA	263..304	CDD:214542
		EGF_3	309..347	CDD:289699
		EGF_3	353..387	CDD:289699
		EGF_CA	399..430	CDD:238011
		EGF_CA	432..468	CDD:238011
		CUB	474..585	CDD:238001
		CUB	590..699	CDD:238001
		CUB	708..815	CDD:238001
		CUB	817..927	CDD:238001
		CUB	932..1041	CDD:238001
		CUB	1048..1157	CDD:294042
		CUB	1165..1275	CDD:238001
		CUB	1282..1388	CDD:238001	11/52 (21%)
		CUB	1391..1505	CDD:238001	25/116 (22%)
		CUB	1510..1617	CDD:238001	17/112 (15%)
		CUB	1620..1733	CDD:238001	32/122 (26%)
		CUB	1738..1847	CDD:238001	31/119 (26%)
		CUB	1859..1962	CDD:238001	4/27 (15%)
		CUB	1978..2088	CDD:278839
		CUB	2092..2212	CDD:238001
		CUB	2217..2333	CDD:238001
		CUB	2336..2447	CDD:238001
		CUB	2452..2564	CDD:238001
		CUB	2570..2686	CDD:238001
		CUB	2689..2800	CDD:238001
		CUB	2805..2918	CDD:238001
		CUB	2920..3034	CDD:238001
		CUB	3037..3148	CDD:238001
		CUB	3157..3273	CDD:238001
		CUB	3278..3392	CDD:238001
		CUB	3395..3506	CDD:238001
		CUB	3511..3621	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR47537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010