DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34402 and KREMEN2

DIOPT Version :9

Sequence 1:	NP_001097756.1	Gene:	CG34402 / 41513	FlyBaseID:	FBgn0085431	Length:	695	Species:	Drosophila melanogaster
Sequence 2:	NP_757384.1	Gene:	KREMEN2 / 79412	HGNCID:	18797	Length:	462	Species:	Homo sapiens

Alignment Length:	341	Identity:	77/341 - (22%)
Similarity:	111/341 - (32%)	Gaps:	105/341 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 SWNLTLNASYRFLKRENFR------------------TDGRLVPHSFCDFYFF---ASLSGEEAN 209
            |..||:....||.:.:.::                  ..|||.|.:.||...|   ..|.|.:..
Human   144 STKLTVQVCLRFCRMKGYQLAGVEAGYACFCGSESDLARGRLAPATDCDQICFGHPGQLCGGDGR 208

  Fly   210 MG----------------QGYFHSPQFPAHYPAHIKCAYKFIGRPDTHVEILFEELQLPPVVSGG 258
            :|                ||..:||.||..|.....|::. :|.|...:|:.|...:|..
Human   209 LGVYEVSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWA-LGPPGAALELTFRLFELAD----- 267

  Fly   259 CQLDALTLFDAESAHMNSVIDVICSSRPTRRLVSTGP------DLLLEFNASSNRTAKGFRGKYK 317
             ..|.|.|.||.|..:....|   .:||.    .:||      .|||.|.:.:...|:||...|:
Human   268 -PRDRLELRDAASGSLLRAFD---GARPP----PSGPLRLGTAALLLTFRSDARGHAQGFALTYR 324

  Fly   318 FV---SNDLGVPNASVPPPAV-LEAASVVVKQEKLQQEQASAAKENSLMSDVE--------LSKP 370
            .:   :.|...|..|...||. |:.|:|...........|..|:..|.::.|.        |.:|
Human   325 GLQDAAEDPEAPEGSAQTPAAPLDGANVSCSPRPGAPPAAIGARVFSTVTAVSVLLLLLLGLLRP 389

  Fly   371 GRSFEQCKQTFDSRVNKSGIFDSNQLLLAKHALGGVVIGGSRVLQCRYEFEAQAPERVQIRFHDF 435
            .|. ..|                   |||. ..|...:|.||..:..:....|.|..|.:
Human   390 LRR-RSC-------------------LLAP-GKGPPALGASRGPRRSWAVWYQQPRGVAL----- 428

  Fly   436 NVPTEHENSTGCQPGD 451
                      .|.|||
Human   429 ----------PCSPGD 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34402	NP_001097756.1	CUB	195..318	CDD:238001	38/147 (26%)
		CUB	<414..512	CDD:238001	7/38 (18%)
		CUB	527..644	CDD:238001
KREMEN2	NP_757384.1	KR	35..119	CDD:238056
		WSC	124..205	CDD:280068	13/60 (22%)
		CUB	219..324	CDD:238001	31/118 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..352		7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910