DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34402 and Tll1

DIOPT Version :9

Sequence 1:	NP_001097756.1	Gene:	CG34402 / 41513	FlyBaseID:	FBgn0085431	Length:	695	Species:	Drosophila melanogaster
Sequence 2:	NP_001099551.1	Gene:	Tll1 / 678743	RGDID:	1306120	Length:	1013	Species:	Rattus norvegicus

Alignment Length:	757	Identity:	138/757 - (18%)
Similarity:	252/757 - (33%)	Gaps:	223/757 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SFTVSHWPLTM-PAASLALGLTVV------------------------LLATGNGQSQQAVTNSK 43
            |:|...|.::: |...:.|..|.:                        ||....|.....|..|.
  Rat   371 SYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKVAGVLTST 435

  Fly    44 QSHFWLDCSCLHLSERNATQW---GRLAI-------------------NASHSLGAKNNCL-MIF 85
            .|..|::.       |:::.|   |..|:                   |..........|: .|.
  Rat   436 DSRMWIEF-------RSSSNWVGKGFAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKIM 493

  Fly    86 IAGMDDELVAFQLEQLQLRAGC-LDSVDIFPYLREPVIENATLAADTFCQHSRERSATPIYSAGR 149
            ::......:.||..:::....| .|.:::    |:...||:.|.. .||.:.:
  Rat   494 VSEGYHVGLTFQAFEIERHDSCAYDHLEV----RDGNSENSPLIG-RFCGYDK------------ 541

  Fly   150 LLGLRLRFQQPPTDLASWNLTLNASYRFLKRENFRTDGRLVPHSFCDFYFFASLSGEEANMG--- 211
                       |.|:.|.:.||     ::|   |.:||.:....|...:|.......:|:.|
  Rat   542 -----------PEDIRSTSNTL-----WMK---FVSDGTVNKAGFAANFFKEEDECAKADRGGCE 587

  Fly   212 --------------------------------------QGYFHSPQFPAHYPAHIKCAYKFIGRP 238
                                                  .|...:|.:|..||.:..|.::.|...
  Rat   588 QRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVIAPS 652

  Fly   239 DTHVEILFEELQLPPVVSGG--CQLDALTLFDAESAHMNSVIDVICSSRPTRRLVSTGPDLLLEF 301
            ...:.:.||..:|    .|.  |:.|.:.::...|:. :.:....|.:.....:.|...::.:||
  Rat   653 QYRISVKFEFFEL----EGNEVCKYDYVEIWSGLSSE-SKLHGKFCGADVPEVITSHFNNMRIEF 712

  Fly   302 NASSNRTAKGFRGKYKFVSNDLGVPNASVPPPAVLEAASVVVKQEKLQQEQASAAKENSLMSDVE 366
            .:.:..:.|||:..: |...|                               ..:|:|.......
  Rat   713 KSDNTVSKKGFKAHF-FSDKD-------------------------------ECSKDNGGCQHEC 745

  Fly   367 LSKPGRSFEQCKQTFDSRVNKSGIFDS--NQLLLAKHALGGVVIG-------GSRVLQCRYEFEA 422
            ::..|....||:..|....||....::  .|.:   |:..|::..       .|| .:|.:...|
  Rat   746 VNTMGSYTCQCRNGFVLHENKHDCKEAECEQKI---HSPSGLITSPNWPDKYPSR-KECTWAISA 806

  Fly   423 QAPERVQIRFHDFNVPTEHENSTGCQPGDALHVVTELRGRYETQEL---LCGAFLPKPLMSSGQQ 484
            ....|:::.|::|.|....|.:.     |.|.:   ..|:.|...:   |||:.:|.|||::|.:
  Rat   807 IPGHRIKLAFNEFEVEQHQECAY-----DHLEI---FDGQTEKSPILGRLCGSKIPDPLMATGNE 863

  Fly   485 LHLQFVGKYPPTMTNKVQYYGFRAEYRFLTNFGIMSGIQKEGCSFVYNSSERISGLFHSPNFPGY 549
            :.::|:.      ...||..||:|.:.  |..|.....:::. ..:|:.::     |...|:||
  Rat   864 MFIRFIS------DASVQRKGFQATHS--TECGGRLKAERKP-KDLYSHAQ-----FGDNNYPG- 913

  Fly   550 YLENVVCNYYFYGASDERVVLHFTYFDIEGIGSCDHQTASDYIE-FSNFMSTDRKFSRYCGKLPD 613
               .:.|.:........|:.|.|..|::|....|.:    ||:| |....|......|:||..|.
  Rat   914 ---QLDCEWLLVSEQGSRLELSFQTFEVEEEADCGY----DYVEVFDGLNSKAVGLGRFCGSGPP 971

  Fly   614 FEMRSDGRFFRVTLHSNDRFVAIGFRALYTF----ETVSVNN 651
            .|:.|.|....:..|::|.....||...|..    ||:...|
  Rat   972 EEIYSIGDVALIHFHTDDTINKKGFYIRYKSIRYPETMHAEN 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34402	NP_001097756.1	CUB	195..318	CDD:238001	24/165 (15%)
		CUB	<414..512	CDD:238001	25/100 (25%)
		CUB	527..644	CDD:238001	29/117 (25%)
Tll1	NP_001099551.1	ZnMc_BMP1_TLD	148..347	CDD:239808
		Astacin	155..348	CDD:279708
		CUB	349..458	CDD:278839	17/93 (18%)
		CUB	462..571	CDD:278839	23/144 (16%)
		FXa_inhibition	582..614	CDD:291342	1/31 (3%)
		CUB	618..727	CDD:278839	21/113 (19%)
		FXa_inhibition	734..769	CDD:291342	8/34 (24%)
		CUB	774..883	CDD:278839	30/126 (24%)
		CUB	887..1000	CDD:278839	29/126 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910