DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34402 and csmd2

DIOPT Version :9

Sequence 1:	NP_001097756.1	Gene:	CG34402 / 41513	FlyBaseID:	FBgn0085431	Length:	695	Species:	Drosophila melanogaster
Sequence 2:	XP_693833.6	Gene:	csmd2 / 565460	ZFINID:	ZDB-GENE-030616-39	Length:	3604	Species:	Danio rerio

Alignment Length:	628	Identity:	123/628 - (19%)
Similarity:	206/628 - (32%)	Gaps:	226/628 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 HSFCDFYFF------ASLSGEEA----NMGQGYFHSPQFPAHYPAHIKCAYKFIGRPDTHVEILF 246
            |.:....||      ||:..:..    :...|...||.:|..||.:..|.:..:.:....::::|
Zfish    43 HHWSGVLFFYMGLLAASVKAQNCSHTLHSPNGTIESPGYPYGYPNYANCTWVIVAQEHNRIQLVF 107

  Fly   247 EELQLPPVVSGGCQLDALTLFDAESAHMNSVIDVICSSRPTRRLVSTGPDLLLEFNASSNRTAKG 311
            :...|..      ..|.|:::|.:.:..|....:.....|. .:|||||.|.|...:....:.:|
Zfish   108 QGFALEE------DFDILSVYDGQPSPTNLRTRLTGFQLPA-PIVSTGPRLTLWLLSDYAVSGQG 165

  Fly   312 FRGKYKFVSNDLGVPNASVPPPAVL----EAASVVVKQEKLQQ--EQASAAKENSLMSDVELSKP 370
            |:..|:      .:|:.:...|..|    :..|.....:|::.  .|....:.::::|.:..|..
Zfish   166 FKAVYE------ALPSYTCGNPGQLLNGMQQGSTFNIGDKIRYSCNQGYVLEGHTVLSCLATSSG 224

  Fly   371 GRSFE----QCKQTFDSRVNKSGIFDSNQLLLAKHALGGVVIGGSRVLQCRYEFEAQAPERVQIR 431
            ..:::    .|:                    |....||.:.|.|.|:        .:|
Zfish   225 TAAWDFPLPYCR--------------------ADDGCGGTLRGQSGVI--------TSP------ 255

  Fly   432 FHDFNVPTEHENSTGC------QPGDAL------------HVVTELRGRYETQELLCGAFLPKPL 478
                |.|.|:.|:..|      :|||.:            :.|.|:.|...:.:...|..||.|:
Zfish   256 ----NYPQEYNNNADCTWTILAEPGDTIALVFSDFQLEEDYDVLEITGTEGSSQWFTGPNLPSPI 316

  Fly   479 MSSGQQLHLQFVGKYPPTMTNKVQYYGFRAEYR-------------------------FLTNFGI 518
            :||...|.|.|      |.....:..||.|:|:                         .|:..|:
Zfish   317 ISSKNWLRLHF------TSDGNHKLRGFSAQYQVKKMTELKSRGVKMLPSKDNHSKISVLSQMGV 375

  Fly   519 MS--------GIQKEG------------------------------C-----SFVYNSSER---- 536
            ..        ||.:.|                              |     |:|..|.:|
Zfish   376 AQGHNMCPDPGIPERGKRKGSDFRRGATVHFSCDEGYELQGSKSITCLRVTDSYVGWSDDRPICR 440

  Fly   537 ----------ISGLFHSPNFPGYYLENVVCNYYFYGASDERVV-LHFTYFDIE--------GIGS 582
                      .||:..|||||..|..|..|.:....:...:|: |.|..||:|        |.||
Zfish   441 APMCGGQLRGPSGIITSPNFPVQYDNNANCTWIITASDSSKVIKLTFEEFDLERGYDTLTVGDGS 505

  Fly   583 C--DHQT---------------ASDYIEFSNFMSTDRKFS-----RY-------CGK--LPDFEM 616
            .  |.:|               ::.:..:.||.:.|...|     .|       ||.  :|.:..
Zfish   506 VIGDQRTVFHVLSGTTTPDLVVSTSHQMWLNFKTDDTSGSLGFKVSYEEIDQGGCGDPGIPAYGK 570

  Fly   617 RSDGRFFRVTLHSNDRFVAIGFRALYTFETVSVNNSITDLRDN 659
            | :|..||   |.:..:    |..|..||.|...| ||..::|
Zfish   571 R-EGTGFR---HGDKLY----FECLPAFELVGKKN-ITCQKNN 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34402	NP_001097756.1	CUB	195..318	CDD:238001	28/132 (21%)
		CUB	<414..512	CDD:238001	26/140 (19%)
		CUB	527..644	CDD:238001	41/175 (23%)
csmd2	XP_693833.6	CUB	65..172	CDD:238001	24/119 (20%)
		CCP	178..236	CDD:153056	7/57 (12%)
		CUB	241..344	CDD:238001	31/126 (25%)
		CCP	382..440	CDD:153056	8/57 (14%)
		CUB	444..553	CDD:238001	25/108 (23%)
		CCP	560..614	CDD:153056	17/54 (31%)
		CUB	617..724	CDD:238001
		CCP	730..788	CDD:153056
		CUB	791..898	CDD:238001
		CCP	906..959	CDD:153056
		CUB	963..1071	CDD:238001
		CCP	1078..1134	CDD:153056
		CUB	1137..1244	CDD:238001
		CCP	1250..1307	CDD:153056
		CUB	1310..1418	CDD:238001
		CCP	1424..1480	CDD:153056
		CUB	1484..1590	CDD:238001
		CCP	1597..1655	CDD:153056
		CUB	1658..1765	CDD:238001
		CCP	1774..1832	CDD:153056
		CUB	1835..1940	CDD:238001
		CCP	1948..2004	CDD:153056
		CUB	2007..2114	CDD:238001
		CCP	2120..2175	CDD:214478
		CUB	2179..2285	CDD:238001
		CCP	2291..2348	CDD:153056
		CUB	2356..2462	CDD:238001
		CCP	2465..2524	CDD:153056
		PHA02927	2523..2767	CDD:222943
		CCP	2528..2586	CDD:153056
		Sushi	2590..2647	CDD:278512
		CCP	2655..2708	CDD:153056
		CCP	2713..2767	CDD:153056
		PHA02927	2765..3006	CDD:222943
		CCP	2771..2825	CDD:153056
		CCP	2829..2887	CDD:153056
		Sushi	2892..2945	CDD:278512
		PHA02927	2953..3242	CDD:222943
		CCP	2953..3006	CDD:153056
		Sushi	3011..3065	CDD:278512
		CCP	3070..3126	CDD:153056
		PHA02927	3130..3363	CDD:222943
		CCP	3130..3183	CDD:153056
		CCP	3188..3242	CDD:153056
		CCP	3249..3304	CDD:153056
		CCP	3308..3363	CDD:153056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910