DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34402 and MYL5

DIOPT Version :9

Sequence 1:	NP_001097756.1	Gene:	CG34402 / 41513	FlyBaseID:	FBgn0085431	Length:	695	Species:	Drosophila melanogaster
Sequence 2:	XP_006713949.1	Gene:	MYL5 / 4636	HGNCID:	7586	Length:	328	Species:	Homo sapiens

Alignment Length:	228	Identity:	44/228 - (19%)
Similarity:	85/228 - (37%)	Gaps:	56/228 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 PNASVP--------PPAVLEAASVVVKQE---KLQQEQASAAKENSLMSDVELSKPGRSFEQCKQ 379
            |:||.|        |...|.:.:...:.|   |.::::..|.:.....|:|..:......::.|:
Human   128 PSASWPCVHTPDCGPGRTLSSCAERRRPEASRKTKKKEGGALRAQRASSNVFSNFEQTQIQEFKE 192

  Fly   380 TF---DSRVNKSGIFDSNQLLLAKHALGGVVIGGSRVLQCRYEFEAQAPERVQIRFHDFNVPTEH 441
            .|   |.  |:.|..|...|.....:||...:.... |....: ||..|    |.|..|
Human   193 AFTLMDQ--NRDGFIDKEDLKDTYASLGKTNVKDDE-LDAMLK-EASGP----INFTMF------ 243

  Fly   442 ENSTGCQPGDALHVVTELRGRYETQELLCGAFLPKPLMSSGQ-QLHLQFVGKYPPTMTNKV---- 501
                       |::..|.....:.:|.:..||  |.|...|: :::.:::.:...:..:|:
Human   244 -----------LNLFGEKLSGTDAEETILNAF--KMLDPDGKGKINKEYIKRLLMSQADKMTAEE 295

  Fly   502 --QYYGFRA-------EYRFLTNFGIMSGIQKE 525
              |.:.|.:       :|:.| ::.|..|.:||
Human   296 VDQMFQFASIDVAGNLDYKAL-SYVITHGEEKE 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34402	NP_001097756.1	CUB	195..318	CDD:238001
		CUB	<414..512	CDD:238001	19/111 (17%)
		CUB	527..644	CDD:238001
MYL5	XP_006713949.1	FRQ1	170..314	CDD:227455	29/170 (17%)
		EFh	189..247	CDD:238008	17/82 (21%)
		EFh	263..314	CDD:238008	8/52 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0031
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900