DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34402 and tld

DIOPT Version :9

Sequence 1:	NP_001097756.1	Gene:	CG34402 / 41513	FlyBaseID:	FBgn0085431	Length:	695	Species:	Drosophila melanogaster
Sequence 2:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster

Alignment Length:	686	Identity:	134/686 - (19%)
Similarity:	240/686 - (34%)	Gaps:	200/686 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 NGQSQQAVTNSKQSHFWLDCSCLHLSERNATQWG--------RLAINASHSLGAKNNCLMI---- 84
            ||..:|.::..                ||..::|        .:..:..|:.|.::..::|
  Fly   210 NGNGRQPISIG----------------RNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGN 258

  Fly    85 FIAGMDDELVAFQLEQLQLRAGCLDSVDIFPYLREPVIENATLAADTFCQHSRERSATPI-YSAG 148
            .:.|.:........|::.|        .:.||....::.   .|.::|.:.....:.||| ...|
  Fly   259 IMRGQEYNFDVLSPEEVDL--------PLLPYDLNSIMH---YAKNSFSKSPYLDTITPIGIPPG 312

  Fly   149 RLLGLRLRFQQPPTDLASWNL-----TLNASYRFLKRENFRTDGRLV-PHSFCDFYFFAS--LSG 205
            ..|.|..|.:....|:...||     :...:|:       :..|.:| ||    |.:..:  ||.
  Fly   313 THLELGQRKRLSRGDIVQANLLYKCASCGRTYQ-------QNSGHIVSPH----FIYSGNGVLSE 366

  Fly   206 EEANMGQGYFHSPQFPAHYPAHI-KCAYKFIGRPDTHVEILFEELQLPPVVSGGCQLDALTLFDA 269
            .|.:...|  ..|...:.:.|.: .|.::........|.:..::|.|  :.|..|..|.|.:.|.
  Fly   367 FEGSGDAG--EDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHL--MSSDDCTQDYLEIRDG 427

  Fly   270 ESAHMNSVIDVICSSRPTRRLVSTGPDLLLEFNASSNRTAKGFRG-KYKFVSNDLGVPNASVPPP 333
             ..|.:.::..||.: .:..:::|....:| .|..:...|||:|| |.:|
  Fly   428 -YWHKSPLVRRICGN-VSGEVITTQTSRML-LNYVNRNAAKGYRGFKARF--------------- 474

  Fly   334 AVLEAASVVVKQEKLQQEQASAAKENSLMSDVELSKPGRSFEQCKQTFDSRVNKSGIFDSNQLLL 398
                                    |.....|::|:| .:|.:......|...:|
  Fly   475 ------------------------EVVCGGDLKLTK-DQSIDSPNYPMDYMPDK----------- 503

  Fly   399 AKHALGGVVIGGSRVLQCRYEFEAQAPERVQIRFHDFNVPTEHENSTGC-----QPGDALHVVTE 458
                            :|.:...|....:|.::|..|    |.|...||     :..|..|..:.
  Fly   504 ----------------ECVWRITAPDNHQVALKFQSF----ELEKHDGCAYDFVEIRDGNHSDSR 548

  Fly   459 LRGRYETQELLCGAFLPKPLMSSGQQLHLQFVGKYPPTMTNKVQYYGFRA-------EYRFLTNF 516
            |.||:      ||..||..:.:...|::::||.      .:.||..||.|       |.:| |:.
  Fly   549 LIGRF------CGDKLPPNIKTRSNQMYIRFVS------DSSVQKLGFSAALMLDVDECKF-TDH 600

  Fly   517 GIMS------GIQKEGCSFVYN----------------SSERISGLFHSPNFPGYYLENVVCNYY 559
            |...      |..:.||...|.                .:.:.:|..:||::|..|..:..|.:.
  Fly   601 GCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWE 665

  Fly   560 FYGASDERVVLHFTYFDIEG----IGSCDHQTASDYIEFSNFMSTDR--KFSRYCG-KLPDFEMR 617
            .....:..|.|:|::||:||    ...|::    ||:...:.|..:|  |...||| :||.. :.
  Fly   666 VVAPPNHAVFLNFSHFDLEGTRFHYTKCNY----DYLIIYSKMRDNRLKKIGIYCGHELPPV-VN 725

  Fly   618 SDGRFFRVTLHSNDRFVAIGFRALYTFET--VSVNN 651
            |:....|:..:|:......||.|.:..:.  .|:||
  Fly   726 SEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNN 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34402	NP_001097756.1	CUB	195..318	CDD:238001	28/126 (22%)
		CUB	<414..512	CDD:238001	27/109 (25%)
		CUB	527..644	CDD:238001	32/139 (23%)
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	26/154 (17%)
		Astacin	144..339	CDD:279708	26/155 (17%)
		CUB	388..474	CDD:214483	21/90 (23%)
		CUB	478..586	CDD:278839	31/151 (21%)
		FXa_inhibition	595..630	CDD:291342	7/35 (20%)
		CUB	634..750	CDD:278839	30/120 (25%)
		FXa_inhibition	757..792	CDD:291342	3/5 (60%)
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910