DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34402 and Tll2

DIOPT Version :9

Sequence 1:	NP_001097756.1	Gene:	CG34402 / 41513	FlyBaseID:	FBgn0085431	Length:	695	Species:	Drosophila melanogaster
Sequence 2:	NP_001178827.1	Gene:	Tll2 / 365460	RGDID:	1559756	Length:	1014	Species:	Rattus norvegicus

Alignment Length:	460	Identity:	99/460 - (21%)
Similarity:	170/460 - (36%)	Gaps:	114/460 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 GYFHSPQFPAHYPAHIKCAYKFIGRPDTHVEILFEELQLPPVVSGG--CQLDALTLFDAES--AH 273
            |...||.:|..||.:..|.::.:......:.:.||..:|    .|.  |:.|.:.:....|  |.
  Rat   628 GTITSPGWPKEYPTNKNCVWQVVAPMQYRISLQFEAFEL----EGNDVCKYDFVEVRSGLSPDAK 688

  Fly   274 MNSVIDVICSSRPTRRLVSTGPDLLLEFNASSNRTAKGFRGKYKFVSNDLGVPNASVPPPAVLEA 338
            ::.   ..|.|.....:.|...::.:||.:.:..:.:|||..: |...|
  Rat   689 LHG---KFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHF-FSDKD---------------- 733

  Fly   339 ASVVVKQEKLQQEQASAAKENSLMSDVELSKPGRSFEQCKQTFDS---------RVNKSGIFDSN 394
                           ..||:|           |...::|..||.|         |::::| .|..
  Rat   734 ---------------ECAKDN-----------GGCQQECVNTFGSYLCRCRNGYRLHENG-HDCK 771

  Fly   395 QLLLA---KHALGGVVIGG------SRVLQCRYEFEAQAPERVQIRFHDFNVPTEHENSTGC--- 447
            :...|   ..|.|.::...      || .:|.:...:.|..||:|.|.:|.|....|    |
  Rat   772 EAGCAYKISSAEGTLMSPNWPDKYPSR-KECTWNISSTAGHRVKITFSEFEVEQHQE----CAYD 831

  Fly   448 --QPGDALHVVTELRGRYETQELLCGAFLPKPLMSSGQQLHLQFVGKYPPTMTNKVQYYGFRAEY 510
              :..|.......:.||:      ||:..|.|::::|..|.|:|..      ...||..||:|.:
  Rat   832 HLELYDGTDSSAPILGRF------CGSKKPDPVVATGSSLFLRFYS------DASVQRKGFQAVH 884

  Fly   511 RFLTNFGIMSGIQ-KEGCSFVYNSSERISGLFHSPNFPGYYLENVVCNYYFYGASDERVVLHFTY 574
            .......:.:.:| ||    :|:.::     |...|:|    ....|::.........|.|.|..
  Rat   885 STECGGRLKAEVQTKE----LYSHAQ-----FGDNNYP----SQAHCDWVIVAEDGYGVELVFRT 936

  Fly   575 FDIEGIGSCDHQTASDYIE-FSNFMSTDRKFSRYCGKLPDFEMRSDGRFFRVTLHSNDRFVAIGF 638
            |::|....|.:    ||:| :..:.|:..:..|:||..|..|:.|.|....:..|::|.....||
  Rat   937 FEVEEEADCGY----DYLEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIHFHTDDTINKKGF 997

  Fly   639 RALYT 643
            .|.||
  Rat   998 HARYT 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34402	NP_001097756.1	CUB	195..318	CDD:238001	23/108 (21%)
		CUB	<414..512	CDD:238001	26/102 (25%)
		CUB	527..644	CDD:238001	29/118 (25%)
Tll2	NP_001178827.1	ZnMc_BMP1_TLD	149..348	CDD:239808
		Astacin	156..349	CDD:279708
		CUB	350..459	CDD:278839
		CUB	463..572	CDD:278839
		FXa_inhibition	583..615	CDD:291342
		CUB	619..728	CDD:278839	23/106 (22%)
		FXa_inhibition	735..770	CDD:291342	10/46 (22%)
		CUB	775..884	CDD:278839	31/125 (25%)
		CUB	888..1001	CDD:278839	30/129 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910