DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34402 and PCOLCE2

DIOPT Version :9

Sequence 1:	NP_001097756.1	Gene:	CG34402 / 41513	FlyBaseID:	FBgn0085431	Length:	695	Species:	Drosophila melanogaster
Sequence 2:	NP_037495.1	Gene:	PCOLCE2 / 26577	HGNCID:	8739	Length:	415	Species:	Homo sapiens

Alignment Length:	335	Identity:	74/335 - (22%)
Similarity:	117/335 - (34%)	Gaps:	89/335 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 NASVPPPAVLEAASVVVKQEKLQQEQASAAKENSLMSDVELSKPGRSFEQC------KQTFDSRV 385
            ||..|...:|.||:.:.:|:                      .|.|....|      :..|....
Human     5 NAWAPLCLLLAAATQLSRQQ----------------------SPERPVFTCGGILTGESGFIGSE 47

  Fly   386 NKSGIFDSNQLLLAKHAL--GGVVIGGSRVLQ------CRYEFEAQAPERVQIRFHDFNVPTEHE 442
            ...|::..|.....|..:  |.||:...|.:.      |||:|              .:|...|.
Human    48 GFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDF--------------VDVYNGHA 98

  Fly   443 NSTGCQPGDALHVVTELRGRYETQELLCGAFLPKPLMSSGQQLHLQFVGKYPPTMTNKVQYYGFR 507
            |      |..:       ||:      ||.|.|..|:|||.::.:|.:.. ..|..|     ||.
Human    99 N------GQRI-------GRF------CGTFRPGALVSSGNKMMVQMISD-ANTAGN-----GFM 138

  Fly   508 AEYRFLTNFGIMSGIQKEGCSFVYNSSERISGLFHSPNFPGY-YLENVVCNYYFYGASDERVVLH 571
            |.:.       .:...:.|..:.....:|.||.|.:||:|.. |...|.|.::.....::.:.|.
Human   139 AMFS-------AAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELK 196

  Fly   572 FTYFDIEGIGSCDHQTASDYIEFSN--FMSTDRKFSRYCGKLPDFEMRSDGRFFRVTLHSNDRFV 634
            |..||:|....|.:    ||:...|  .::..|:..:|||..|...:.|:.....:...|:....
Human   197 FEKFDVERDNYCRY----DYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLT 257

  Fly   635 AIGFRALYTF 644
            |.||...|.|
Human   258 ADGFIGHYIF 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34402	NP_001097756.1	CUB	195..318	CDD:238001
		CUB	<414..512	CDD:238001	24/103 (23%)
		CUB	527..644	CDD:238001	30/119 (25%)
PCOLCE2	NP_037495.1	CUB	33..143	CDD:238001	33/155 (21%)
		CUB	154..267	CDD:238001	30/116 (26%)
		NTR_PCOLCE	292..415	CDD:239631
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4379
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910