DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34402 and lev-10

DIOPT Version :9

Sequence 1:	NP_001097756.1	Gene:	CG34402 / 41513	FlyBaseID:	FBgn0085431	Length:	695	Species:	Drosophila melanogaster
Sequence 2:	NP_001021691.1	Gene:	lev-10 / 24105310	WormBaseID:	WBGene00002977	Length:	906	Species:	Caenorhabditis elegans

Alignment Length:	717	Identity:	157/717 - (21%)
Similarity:	266/717 - (37%)	Gaps:	134/717 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LGLTVVLLATGNGQSQQAVTNSKQSHFWLDCSCLHLSE---RNATQWGRLAINASHSLGAKNN-- 80
            |.|..:.::..:|.|::.:....|          |..|   ....::..|....:.|.|..|:
Worm     6 LFLLSIFVSKADGNSRKTIFQCDQ----------HFDESQPEGVIEFPSLPKQLALSHGVNNSKP 60

  Fly    81 -------CLMIFIAGMDDELVAFQLEQLQLRA---GC-LDSVDIFPYLREPVIENATLAA----- 129
                   |:..|:|| ..:.|..:.:...|..   .| ::.|||:..: |.|.|:...:|
Worm    61 EQQYNLQCVYTFVAG-SRQRVRLEFDHFLLSGSSENCDIEYVDIYSEV-ESVDEDILSSALGGRY 123

  Fly   130 -DTFCQHSRERSATPIYSAGRLLGLRLRFQQPPTDLASWNLTLNASYRFLKRENFRTDGRLVPHS 193
             .|...|.|       .|..|::.|.|..:....:   .|....|.|.|:..:.| ..|..|...
Worm   124 CGTVAPHVR-------ISLRRVMKLVLHSRSTNHE---DNHGFRAKYSFIPEDKF-IAGEPVGGK 177

  Fly   194 FCDFYFFASLSGEEANMGQGYFHSPQFPAHYPAHIKCAYKFIGRPDTHVEILFEELQLPPVVSGG 258
            .|.|..      :.::...|..:||.:|..||.::.|:|.........:.:.|.:..   :..||
Worm   178 KCSFII------DSSDRKIGTLYSPTYPGTYPHNMHCSYLMKAGRGERIRLFFTDFD---IFFGG 233

  Fly   259 --CQLDALTLFDAESAHMNSVIDVICSSRPTRRLVSTGPDLLLEFNAS--SNRTAKGFRGKYKFV 319
              |..|::|:||..:. .:.:|..:|..:....:.|.|..||:.||.:  :....:||...|:|.
Worm   234 EHCPYDSVTIFDGPTP-ASPIIRKVCGLQQRMEVYSMGNSLLIHFNTTHPAKSDPRGFIMDYEFS 297

  Fly   320 SNDLGVPNASVPPPAVLEAASVVVKQEKLQQEQASAAKENSLMSDVELSKPGRSFEQCKQTFD-- 382
            :..:.:                    :||..:|...........||.:       |..::||.
Worm   298 TRFVNI--------------------DKLLNKQRGVTHIRGTECDVRV-------ESNRETFHTI 335

  Fly   383 SRVNKSGIFDSNQL-------LLAKHALGGVVIGGSRVLQCRYEFE-AQAPERVQIRFHDFNVPT 439
            |..|...::.:|..       |..:..|..|::....:....::.. |.||....|  .|...|:
Worm   336 SSPNYPEVYPANTTCTYIIHGLQGEQNLEKVILTFDSIAVLSFDTSPATAPPSADI--DDIACPS 398

  Fly   440 EHENSTGCQPGDA-LHVVTELRGRYETQELLCGAFLPK-----PLMSSGQQLHLQFVGKYPPTMT 498
            ..   .|...|:. :..|............||....|.     |.:|.|.::.:||..  ..|..
Worm   399 AW---VGIAIGEGNMKAVMSSTDDSTFDVTLCERIPPNSPLLGPYISEGPRMVMQFGS--TETRD 458

  Fly   499 NKVQYYGFRAEYRFLTNFGIMS---GIQKEGCSFVYNSSERISGLFHSPNFPGYYLENVVCNYYF 560
            :.:...||:|...|.|:||:..   |...| |.|.:.||   :|.|:||.:|..|..:..|.||.
Worm   459 DNISPIGFKATIEFKTDFGVTGESLGTSNE-CKFRFTSS---TGFFNSPRYPANYPLDTNCTYYI 519

  Fly   561 YGASDERVVLHFTYFDIEGIGSCDHQTASDYIE-FSNFMSTD----RKFSRYCG-KLPDFEMRSD 619
            .|...:.::|||..|.:.  |:.|: ..:||:: :..|:...    |:..|||. ..|...:.:.
Worm   520 VGQPGKEILLHFEQFALS--GNTDN-NCNDYLDVYDVFVKNGKEELRRKERYCADTFPGPSVSAF 581

  Fly   620 GRF-FRVTLHSNDRFVAIGFRALYTFETV---SVNNSITDLRDNA-SMQSFVSTASTQPVANVNK 679
            |.. .||...|.....|.||:||:...|.   .|......:|..| ...|.:::.|.:|    |.
Worm   582 GSHEMRVVFTSGSSGTANGFKALFEIRTARKEDVPRGEAHIRRGAYRCGSVINSTSEKP----NG 642

  Fly   680 LI 681
            ||
Worm   643 LI 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34402	NP_001097756.1	CUB	195..318	CDD:238001	29/126 (23%)
		CUB	<414..512	CDD:238001	21/104 (20%)
		CUB	527..644	CDD:238001	37/123 (30%)
lev-10	NP_001021691.1	CUB	27..162	CDD:238001	31/156 (20%)
		CUB	179..296	CDD:238001	29/126 (23%)
		CUB	330..472	CDD:238001	29/148 (20%)
		CUB	489..607	CDD:238001	37/123 (30%)
		CUB	629..746	CDD:238001	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D179423at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920